Diacylglycerol kinase β knockout mice exhibit lithium-sensitive behavioral abnormalities.
Diacylglycerol kinase (DGK) is an enzyme that phosphorylates diacylglycerol (DG) to produce phosphatidic acid (PA). DGKβ is widely distributed in the central nervous system, such as the olfactory bulb, cerebral cortex, striatum, and hippocampus. Recent studies reported that the splice variant at the...
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doaj-a06be1daa178461eba35dbc367bee2232020-11-25T02:47:04ZengPublic Library of Science (PLoS)PLoS ONE1932-62032010-10-01510e1344710.1371/journal.pone.0013447Diacylglycerol kinase β knockout mice exhibit lithium-sensitive behavioral abnormalities.Kenichi KakefudaAtsushi OyagiMitsue IshisakaKazuhiro TsurumaMasamitsu ShimazawaKoichi YokotaYasuhito ShiraiKyoji HorieNaoaki SaitoJunji TakedaHideaki HaraDiacylglycerol kinase (DGK) is an enzyme that phosphorylates diacylglycerol (DG) to produce phosphatidic acid (PA). DGKβ is widely distributed in the central nervous system, such as the olfactory bulb, cerebral cortex, striatum, and hippocampus. Recent studies reported that the splice variant at the COOH-terminal of DGKβ was related to bipolar disorder, but its detailed mechanism is still unknown.In the present study, we performed behavioral tests using DGKβ knockout (KO) mice to investigate the effects of DGKβ deficits on psychomotor behavior. DGKβ KO mice exhibited some behavioral abnormalities, such as hyperactivity, reduced anxiety, and reduced depression. Additionally, hyperactivity and reduced anxiety were attenuated by the administration of the mood stabilizer, lithium, but not haloperidol, diazepam, or imipramine. Moreover, DGKβ KO mice showed impairment in Akt-glycogen synthesis kinase (GSK) 3β signaling and cortical spine formation.These findings suggest that DGKβ KO mice exhibit lithium-sensitive behavioral abnormalities that are, at least in part, due to the impairment of Akt-GSK3β signaling and cortical spine formation.http://europepmc.org/articles/PMC2956634?pdf=render |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Kenichi Kakefuda Atsushi Oyagi Mitsue Ishisaka Kazuhiro Tsuruma Masamitsu Shimazawa Koichi Yokota Yasuhito Shirai Kyoji Horie Naoaki Saito Junji Takeda Hideaki Hara |
spellingShingle |
Kenichi Kakefuda Atsushi Oyagi Mitsue Ishisaka Kazuhiro Tsuruma Masamitsu Shimazawa Koichi Yokota Yasuhito Shirai Kyoji Horie Naoaki Saito Junji Takeda Hideaki Hara Diacylglycerol kinase β knockout mice exhibit lithium-sensitive behavioral abnormalities. PLoS ONE |
author_facet |
Kenichi Kakefuda Atsushi Oyagi Mitsue Ishisaka Kazuhiro Tsuruma Masamitsu Shimazawa Koichi Yokota Yasuhito Shirai Kyoji Horie Naoaki Saito Junji Takeda Hideaki Hara |
author_sort |
Kenichi Kakefuda |
title |
Diacylglycerol kinase β knockout mice exhibit lithium-sensitive behavioral abnormalities. |
title_short |
Diacylglycerol kinase β knockout mice exhibit lithium-sensitive behavioral abnormalities. |
title_full |
Diacylglycerol kinase β knockout mice exhibit lithium-sensitive behavioral abnormalities. |
title_fullStr |
Diacylglycerol kinase β knockout mice exhibit lithium-sensitive behavioral abnormalities. |
title_full_unstemmed |
Diacylglycerol kinase β knockout mice exhibit lithium-sensitive behavioral abnormalities. |
title_sort |
diacylglycerol kinase β knockout mice exhibit lithium-sensitive behavioral abnormalities. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS ONE |
issn |
1932-6203 |
publishDate |
2010-10-01 |
description |
Diacylglycerol kinase (DGK) is an enzyme that phosphorylates diacylglycerol (DG) to produce phosphatidic acid (PA). DGKβ is widely distributed in the central nervous system, such as the olfactory bulb, cerebral cortex, striatum, and hippocampus. Recent studies reported that the splice variant at the COOH-terminal of DGKβ was related to bipolar disorder, but its detailed mechanism is still unknown.In the present study, we performed behavioral tests using DGKβ knockout (KO) mice to investigate the effects of DGKβ deficits on psychomotor behavior. DGKβ KO mice exhibited some behavioral abnormalities, such as hyperactivity, reduced anxiety, and reduced depression. Additionally, hyperactivity and reduced anxiety were attenuated by the administration of the mood stabilizer, lithium, but not haloperidol, diazepam, or imipramine. Moreover, DGKβ KO mice showed impairment in Akt-glycogen synthesis kinase (GSK) 3β signaling and cortical spine formation.These findings suggest that DGKβ KO mice exhibit lithium-sensitive behavioral abnormalities that are, at least in part, due to the impairment of Akt-GSK3β signaling and cortical spine formation. |
url |
http://europepmc.org/articles/PMC2956634?pdf=render |
work_keys_str_mv |
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