Reduced competence to arboviruses following the sustainable invasion of Wolbachia into native Aedes aegypti from Southeastern Brazil
Abstract Field release of Wolbachia-infected Aedes aegypti has emerged as a promising solution to manage the transmission of dengue, Zika and chikungunya in endemic areas across the globe. Through an efficient self-dispersing mechanism, and the ability to induce virus-blocking properties, Wolbachia...
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doaj-a08174d192d44cd8bbb2f24167134d8b2021-05-11T14:55:59ZengNature Publishing GroupScientific Reports2045-23222021-05-0111111410.1038/s41598-021-89409-8Reduced competence to arboviruses following the sustainable invasion of Wolbachia into native Aedes aegypti from Southeastern BrazilJoão Silveira Moledo Gesto0Gabriel Sylvestre Ribeiro1Marcele Neves Rocha2Fernando Braga Stehling Dias3Julia Peixoto4Fabiano Duarte Carvalho5Thiago Nunes Pereira6Luciano Andrade Moreira7Grupo Mosquitos Vetores: Endossimbiontes e Interação Patógeno Vetor, Instituto René Rachou, Fiocruz MinasGrupo Mosquitos Vetores: Endossimbiontes e Interação Patógeno Vetor, Instituto René Rachou, Fiocruz MinasGrupo Mosquitos Vetores: Endossimbiontes e Interação Patógeno Vetor, Instituto René Rachou, Fiocruz MinasFiocruz CearáWorld Mosquito Program, FiocruzGrupo Mosquitos Vetores: Endossimbiontes e Interação Patógeno Vetor, Instituto René Rachou, Fiocruz MinasGrupo Mosquitos Vetores: Endossimbiontes e Interação Patógeno Vetor, Instituto René Rachou, Fiocruz MinasGrupo Mosquitos Vetores: Endossimbiontes e Interação Patógeno Vetor, Instituto René Rachou, Fiocruz MinasAbstract Field release of Wolbachia-infected Aedes aegypti has emerged as a promising solution to manage the transmission of dengue, Zika and chikungunya in endemic areas across the globe. Through an efficient self-dispersing mechanism, and the ability to induce virus-blocking properties, Wolbachia offers an unmatched potential to gradually modify wild Ae. aegypti populations turning them unsuitable disease vectors. Here we describe a proof-of-concept field trial carried out in a small community of Niterói, greater Rio de Janeiro, Brazil. Following the release of Wolbachia-infected eggs, we report here a successful invasion and long-term establishment of the bacterium across the territory, as denoted by stable high-infection indexes (> 80%). We have also demonstrated that refractoriness to dengue and Zika viruses, either thorough oral-feeding or intra-thoracic saliva challenging assays, was maintained over the adaptation to the natural environment of Southeastern Brazil. These findings further support Wolbachia’s ability to invade local Ae. aegypti populations and impair disease transmission, and will pave the way for future epidemiological and economic impact assessments.https://doi.org/10.1038/s41598-021-89409-8 |
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DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
João Silveira Moledo Gesto Gabriel Sylvestre Ribeiro Marcele Neves Rocha Fernando Braga Stehling Dias Julia Peixoto Fabiano Duarte Carvalho Thiago Nunes Pereira Luciano Andrade Moreira |
spellingShingle |
João Silveira Moledo Gesto Gabriel Sylvestre Ribeiro Marcele Neves Rocha Fernando Braga Stehling Dias Julia Peixoto Fabiano Duarte Carvalho Thiago Nunes Pereira Luciano Andrade Moreira Reduced competence to arboviruses following the sustainable invasion of Wolbachia into native Aedes aegypti from Southeastern Brazil Scientific Reports |
author_facet |
João Silveira Moledo Gesto Gabriel Sylvestre Ribeiro Marcele Neves Rocha Fernando Braga Stehling Dias Julia Peixoto Fabiano Duarte Carvalho Thiago Nunes Pereira Luciano Andrade Moreira |
author_sort |
João Silveira Moledo Gesto |
title |
Reduced competence to arboviruses following the sustainable invasion of Wolbachia into native Aedes aegypti from Southeastern Brazil |
title_short |
Reduced competence to arboviruses following the sustainable invasion of Wolbachia into native Aedes aegypti from Southeastern Brazil |
title_full |
Reduced competence to arboviruses following the sustainable invasion of Wolbachia into native Aedes aegypti from Southeastern Brazil |
title_fullStr |
Reduced competence to arboviruses following the sustainable invasion of Wolbachia into native Aedes aegypti from Southeastern Brazil |
title_full_unstemmed |
Reduced competence to arboviruses following the sustainable invasion of Wolbachia into native Aedes aegypti from Southeastern Brazil |
title_sort |
reduced competence to arboviruses following the sustainable invasion of wolbachia into native aedes aegypti from southeastern brazil |
publisher |
Nature Publishing Group |
series |
Scientific Reports |
issn |
2045-2322 |
publishDate |
2021-05-01 |
description |
Abstract Field release of Wolbachia-infected Aedes aegypti has emerged as a promising solution to manage the transmission of dengue, Zika and chikungunya in endemic areas across the globe. Through an efficient self-dispersing mechanism, and the ability to induce virus-blocking properties, Wolbachia offers an unmatched potential to gradually modify wild Ae. aegypti populations turning them unsuitable disease vectors. Here we describe a proof-of-concept field trial carried out in a small community of Niterói, greater Rio de Janeiro, Brazil. Following the release of Wolbachia-infected eggs, we report here a successful invasion and long-term establishment of the bacterium across the territory, as denoted by stable high-infection indexes (> 80%). We have also demonstrated that refractoriness to dengue and Zika viruses, either thorough oral-feeding or intra-thoracic saliva challenging assays, was maintained over the adaptation to the natural environment of Southeastern Brazil. These findings further support Wolbachia’s ability to invade local Ae. aegypti populations and impair disease transmission, and will pave the way for future epidemiological and economic impact assessments. |
url |
https://doi.org/10.1038/s41598-021-89409-8 |
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