Proprioception mediates the association between systemic inflammation and muscle weakness in patients with knee osteoarthritis: Results from the Amsterdam Osteoarthritis cohort
Objectives: To determine whether systemic inflammation is associated with poor proprioception; to confirm that systemic inflammation is associated with muscle weakness; and to determine whether poor proprioception mediates the association between systemic inflammation and muscle weakness in knee ost...
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2017-09-01
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doaj-a088ac40fa1048ba9a0d8dab3c5e28ad2020-11-25T00:06:30ZengFoundation for Rehabilitation InformationJournal of Rehabilitation Medicine1650-19771651-20812017-09-01501677210.2340/16501977-22722353Proprioception mediates the association between systemic inflammation and muscle weakness in patients with knee osteoarthritis: Results from the Amsterdam Osteoarthritis cohortTomasz Cudejko0Martin van der EschMarike van der LeedenJasmijn HollaLeo D. RoordaWillem LemsJoost Dekker Rehabilitation Medicine, VU University Medical Center, 1081 HV Amsterdam, The Netherlands. t.cudejko@vumc.nl. Objectives: To determine whether systemic inflammation is associated with poor proprioception; to confirm that systemic inflammation is associated with muscle weakness; and to determine whether poor proprioception mediates the association between systemic inflammation and muscle weakness in knee osteoarthritis. Design: Cross-sectional study. Subjects: A total of 689 participants with knee osteoarthritis from the Amsterdam Osteoarthritis (AMS-OA) cohort. Methods: Systemic inflammation was assessed by erythrocyte sedimentation rate, knee proprioception by determining the joint motion detection threshold, and muscle strength with an isokinetic dynamometer. Linear regression models were used to estimate direct associations between systemic inflammation, proprioception and muscle strength, and the indirect association (mediation) between systemic inflammation and muscle strength via proprioception adjusted for potential confounders. Results: Higher erythrocyte sedimentation rates were associated with poor proprioception (p = 0.022). Poor proprioception (p < 0.001) and higher erythrocyte sedimentation rates (p < 0.001) were associated with muscle weakness. Poor proprio-ception mediated the association between systemic inflammation and muscle weakness (p = 0.035). Conclusion: Results suggest that systemic inflammation is associated with poor proprioception in knee osteoarthritis. Poor proprioception may be a path-way through which systemic inflammation is associated with muscle weakness in patients with knee osteoarthritis. https://www.medicaljournals.se/jrm/content/html/10.2340/16501977-2272 osteoarthritiskneemusclestrengthinflammationproprioception. |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Tomasz Cudejko Martin van der Esch Marike van der Leeden Jasmijn Holla Leo D. Roorda Willem Lems Joost Dekker |
spellingShingle |
Tomasz Cudejko Martin van der Esch Marike van der Leeden Jasmijn Holla Leo D. Roorda Willem Lems Joost Dekker Proprioception mediates the association between systemic inflammation and muscle weakness in patients with knee osteoarthritis: Results from the Amsterdam Osteoarthritis cohort Journal of Rehabilitation Medicine osteoarthritis knee musclestrength inflammation proprioception. |
author_facet |
Tomasz Cudejko Martin van der Esch Marike van der Leeden Jasmijn Holla Leo D. Roorda Willem Lems Joost Dekker |
author_sort |
Tomasz Cudejko |
title |
Proprioception mediates the association between systemic inflammation and muscle weakness in patients with knee osteoarthritis: Results from the Amsterdam Osteoarthritis cohort |
title_short |
Proprioception mediates the association between systemic inflammation and muscle weakness in patients with knee osteoarthritis: Results from the Amsterdam Osteoarthritis cohort |
title_full |
Proprioception mediates the association between systemic inflammation and muscle weakness in patients with knee osteoarthritis: Results from the Amsterdam Osteoarthritis cohort |
title_fullStr |
Proprioception mediates the association between systemic inflammation and muscle weakness in patients with knee osteoarthritis: Results from the Amsterdam Osteoarthritis cohort |
title_full_unstemmed |
Proprioception mediates the association between systemic inflammation and muscle weakness in patients with knee osteoarthritis: Results from the Amsterdam Osteoarthritis cohort |
title_sort |
proprioception mediates the association between systemic inflammation and muscle weakness in patients with knee osteoarthritis: results from the amsterdam osteoarthritis cohort |
publisher |
Foundation for Rehabilitation Information |
series |
Journal of Rehabilitation Medicine |
issn |
1650-1977 1651-2081 |
publishDate |
2017-09-01 |
description |
Objectives: To determine whether systemic inflammation is associated with poor proprioception; to confirm that systemic inflammation is associated with muscle weakness; and to determine whether poor proprioception mediates the association between systemic inflammation and muscle weakness in knee osteoarthritis.
Design: Cross-sectional study.
Subjects: A total of 689 participants with knee osteoarthritis from the Amsterdam Osteoarthritis (AMS-OA) cohort.
Methods: Systemic inflammation was assessed by erythrocyte sedimentation rate, knee proprioception by determining the joint motion detection threshold, and muscle strength with an isokinetic dynamometer. Linear regression models were used to estimate direct associations between systemic inflammation, proprioception and muscle strength, and the indirect association (mediation) between systemic inflammation and muscle strength via proprioception adjusted for potential confounders.
Results: Higher erythrocyte sedimentation rates were associated with poor proprioception (p = 0.022). Poor proprioception (p < 0.001) and higher erythrocyte sedimentation rates (p < 0.001) were associated with muscle weakness. Poor proprio-ception mediated the association between systemic inflammation and muscle weakness (p = 0.035).
Conclusion: Results suggest that systemic inflammation is associated with poor proprioception in knee osteoarthritis. Poor proprioception may be a path-way through which systemic inflammation is associated with muscle weakness in patients with knee osteoarthritis. |
topic |
osteoarthritis knee musclestrength inflammation proprioception. |
url |
https://www.medicaljournals.se/jrm/content/html/10.2340/16501977-2272
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work_keys_str_mv |
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