Heterocyclic Substitutions Greatly Improve Affinity and Stability of Folic Acid towards FRα. An In Silico Insight
Folate receptor alpha (FRα) is known as a biological marker for many cancers due to its overexpression in cancerous epithelial tissue. The folic acid (FA) binding affinity to the FRα active site provides a basis for designing more specific targets for FRα. Heterocyclic rings have been shown to inter...
Main Authors: | Mohammad G. Al-Thiabat, Fadi G. Saqallah, Amirah Mohd Gazzali, Noratiqah Mohtar, Beow Keat Yap, Yee Siew Choong, Habibah A Wahab |
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Format: | Article |
Language: | English |
Published: |
MDPI AG
2021-02-01
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Series: | Molecules |
Subjects: | |
Online Access: | https://www.mdpi.com/1420-3049/26/4/1079 |
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