Intermittent Hypoxic Conditioning Alleviates Post-Traumatic Stress Disorder-Induced Damage and Dysfunction of Rat Visceral Organs and Brain
Posttraumatic stress disorder (PTSD) causes mental and somatic diseases. Intermittent hypoxic conditioning (IHC) has cardio-, vaso-, and neuroprotective effects and alleviates experimental PTSD. IHC’s ability to alleviate harmful PTSD effects on rat heart, liver, and brain was examined. PT...
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doaj-a0923e19a98c42dab1d3c79745559c6e2020-11-25T01:12:56ZengMDPI AGInternational Journal of Molecular Sciences1422-00672020-01-0121134510.3390/ijms21010345ijms21010345Intermittent Hypoxic Conditioning Alleviates Post-Traumatic Stress Disorder-Induced Damage and Dysfunction of Rat Visceral Organs and BrainEugenia B. Manukhina0Vadim E. Tseilikman1Marina N. Karpenko2Nina S. Pestereva3Olga B. Tseilikman4Maria V. Komelkova5Marina V. Kondashevskaya6Anna V. Goryacheva7Maxim S. Lapshin8Pavel O. Platkovskii9Alexey P. Sarapultsev10Anatoly V. Alliluev11H. Fred Downey12School of Medical Biology, South Ural State University, Chelyabinsk 454080, RussiaSchool of Medical Biology, South Ural State University, Chelyabinsk 454080, RussiaI.P. Pavlov Physiology Department, Institute of Experimental Medicine, St. Petersburg 197376, RussiaI.P. Pavlov Physiology Department, Institute of Experimental Medicine, St. Petersburg 197376, RussiaSchool of Medical Biology, South Ural State University, Chelyabinsk 454080, RussiaSchool of Medical Biology, South Ural State University, Chelyabinsk 454080, RussiaLaboratory for Immunomorphology of Inflammation, Research Institute of Human Morphology, Moscow 117418, RussiaLaboratory for Regulatory Mechanisms of Stress and Adaptation, Institute of General Pathology and Pathophysiology, Moscow 125315, RussiaSchool of Medical Biology, South Ural State University, Chelyabinsk 454080, RussiaSchool of Medical Biology, South Ural State University, Chelyabinsk 454080, RussiaLaboratory of Immunopathophysiology, Institute of Immunology and Physiology of the Ural Branch of the Russian Academy of Sciences, Ekaterinburg 620049, RussiaSchool of Medical Biology, South Ural State University, Chelyabinsk 454080, RussiaSchool of Medical Biology, South Ural State University, Chelyabinsk 454080, RussiaPosttraumatic stress disorder (PTSD) causes mental and somatic diseases. Intermittent hypoxic conditioning (IHC) has cardio-, vaso-, and neuroprotective effects and alleviates experimental PTSD. IHC’s ability to alleviate harmful PTSD effects on rat heart, liver, and brain was examined. PTSD was induced by 10-day exposure to cat urine scent (PTSD rats). Some rats were then adapted to 14-day IHC (PTSD+IHC rats), while PTSD and untreated control rats were cage rested. PTSD rats had a higher anxiety index (AI, X-maze test), than control or PTSD+IHC rats. This higher AI was associated with reduced glycogen content and histological signs of metabolic and hypoxic damage and of impaired contractility. The livers of PTSD rats had reduced glycogen content. Liver and blood alanine and aspartate aminotransferase activities of PTSD rats were significantly increased. PTSD rats had increased norepinephrine concentration and decreased monoamine oxidase A activity in cerebral cortex. The PTSD-induced elevation of carbonylated proteins and lipid peroxidation products in these organs reflects oxidative stress, a known cause of organ pathology. IHC alleviated PTSD-induced metabolic and structural injury and reduced oxidative stress. Therefore, IHC is a promising preventive treatment for PTSD-related morphological and functional damage to organs, due, in part, to IHC’s reduction of oxidative stress.https://www.mdpi.com/1422-0067/21/1/345posttraumatic stress disorderintermittent hypoxia conditioningheartliverbrainoxidative stress |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Eugenia B. Manukhina Vadim E. Tseilikman Marina N. Karpenko Nina S. Pestereva Olga B. Tseilikman Maria V. Komelkova Marina V. Kondashevskaya Anna V. Goryacheva Maxim S. Lapshin Pavel O. Platkovskii Alexey P. Sarapultsev Anatoly V. Alliluev H. Fred Downey |
spellingShingle |
Eugenia B. Manukhina Vadim E. Tseilikman Marina N. Karpenko Nina S. Pestereva Olga B. Tseilikman Maria V. Komelkova Marina V. Kondashevskaya Anna V. Goryacheva Maxim S. Lapshin Pavel O. Platkovskii Alexey P. Sarapultsev Anatoly V. Alliluev H. Fred Downey Intermittent Hypoxic Conditioning Alleviates Post-Traumatic Stress Disorder-Induced Damage and Dysfunction of Rat Visceral Organs and Brain International Journal of Molecular Sciences posttraumatic stress disorder intermittent hypoxia conditioning heart liver brain oxidative stress |
author_facet |
Eugenia B. Manukhina Vadim E. Tseilikman Marina N. Karpenko Nina S. Pestereva Olga B. Tseilikman Maria V. Komelkova Marina V. Kondashevskaya Anna V. Goryacheva Maxim S. Lapshin Pavel O. Platkovskii Alexey P. Sarapultsev Anatoly V. Alliluev H. Fred Downey |
author_sort |
Eugenia B. Manukhina |
title |
Intermittent Hypoxic Conditioning Alleviates Post-Traumatic Stress Disorder-Induced Damage and Dysfunction of Rat Visceral Organs and Brain |
title_short |
Intermittent Hypoxic Conditioning Alleviates Post-Traumatic Stress Disorder-Induced Damage and Dysfunction of Rat Visceral Organs and Brain |
title_full |
Intermittent Hypoxic Conditioning Alleviates Post-Traumatic Stress Disorder-Induced Damage and Dysfunction of Rat Visceral Organs and Brain |
title_fullStr |
Intermittent Hypoxic Conditioning Alleviates Post-Traumatic Stress Disorder-Induced Damage and Dysfunction of Rat Visceral Organs and Brain |
title_full_unstemmed |
Intermittent Hypoxic Conditioning Alleviates Post-Traumatic Stress Disorder-Induced Damage and Dysfunction of Rat Visceral Organs and Brain |
title_sort |
intermittent hypoxic conditioning alleviates post-traumatic stress disorder-induced damage and dysfunction of rat visceral organs and brain |
publisher |
MDPI AG |
series |
International Journal of Molecular Sciences |
issn |
1422-0067 |
publishDate |
2020-01-01 |
description |
Posttraumatic stress disorder (PTSD) causes mental and somatic diseases. Intermittent hypoxic conditioning (IHC) has cardio-, vaso-, and neuroprotective effects and alleviates experimental PTSD. IHC’s ability to alleviate harmful PTSD effects on rat heart, liver, and brain was examined. PTSD was induced by 10-day exposure to cat urine scent (PTSD rats). Some rats were then adapted to 14-day IHC (PTSD+IHC rats), while PTSD and untreated control rats were cage rested. PTSD rats had a higher anxiety index (AI, X-maze test), than control or PTSD+IHC rats. This higher AI was associated with reduced glycogen content and histological signs of metabolic and hypoxic damage and of impaired contractility. The livers of PTSD rats had reduced glycogen content. Liver and blood alanine and aspartate aminotransferase activities of PTSD rats were significantly increased. PTSD rats had increased norepinephrine concentration and decreased monoamine oxidase A activity in cerebral cortex. The PTSD-induced elevation of carbonylated proteins and lipid peroxidation products in these organs reflects oxidative stress, a known cause of organ pathology. IHC alleviated PTSD-induced metabolic and structural injury and reduced oxidative stress. Therefore, IHC is a promising preventive treatment for PTSD-related morphological and functional damage to organs, due, in part, to IHC’s reduction of oxidative stress. |
topic |
posttraumatic stress disorder intermittent hypoxia conditioning heart liver brain oxidative stress |
url |
https://www.mdpi.com/1422-0067/21/1/345 |
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