Quantitative Imaging of White and Gray Matter Remyelination in the Cuprizone Demyelination Model Using the Macromolecular Proton Fraction

Quantitative Imaging of White and Gray Matter Remyelination in the Cuprizone Demyelination Model Using the Macromolecular Proton Fraction

Macromolecular proton fraction (MPF) has been established as a quantitative clinically-targeted MRI myelin biomarker based on recent demyelination studies. This study aimed to assess the capability of MPF to quantify remyelination using the murine cuprizone-induced reversible demyelination model. MP...

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Bibliographic Details
Main Authors: Marina Khodanovich, Anna Pishchelko, Valentina Glazacheva, Edgar Pan, Andrey Akulov, Mikhail Svetlik, Yana Tyumentseva, Tatyana Anan’ina, Vasily Yarnykh
Format: Article
Language:English
Published: MDPI AG 2019-10-01
Series:Cells
Subjects:
macromolecular proton fraction
mpf
myelin
magnetic resonance imaging
cuprizone model
demyelination
remyelination
oligodendrocyte precursors
oligodendrocytes
immunohistochemistry
Online Access:https://www.mdpi.com/2073-4409/8/10/1204

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