Fosfomycin: An Alternative Therapy for the Treatment of UTI Amidst Escalating Antimicrobial Resistance
Introduction: Urinary tract infections (UTIs) are the most commonly encountered infectious diseases. The current study was undertaken with a dual purpose, to provide an insight into the current scenario of the microorganisms causing UTI, their antimicrobial sensitivity patterns and also try and...
Main Authors: | , |
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Format: | Article |
Language: | English |
Published: |
JCDR Research and Publications Private Limited
2015-12-01
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Series: | Journal of Clinical and Diagnostic Research |
Subjects: | |
Online Access: | https://jcdr.net/articles/PDF/6951/15227_CE(RA1)_F(T)_PF1(BMAK)_PFA(AK)_PF2(PAG).pdf |
Summary: | Introduction: Urinary tract infections (UTIs) are the most
commonly encountered infectious diseases. The current study
was undertaken with a dual purpose, to provide an insight into
the current scenario of the microorganisms causing UTI, their
antimicrobial sensitivity patterns and also try and evaluate the
activity of fosfomycin against E. coli, both ESBL producers as
well as non-producers.
Materials and Methods: The study was conducted prospectively
in the Department of Microbiology of a tertiary care hospital from
January to June 2014. A total of 358 isolates from the urinary
samples of the patients with a diagnosis of urinary tract infection
were included in the study. Antibiotic sensitivity testing and
extended spectrum beta lactamase (ESBL) production testing
was done as per CLSI guidelines.
Results: These represented 297 (82.9%) gram-negative
isolates and 61 (17%) gram-positive isolates. The 297 gramnegative isolates represented 265 (89.2%) members of the
Enterobacteriaceae, 185 (69.8%) of which were Escherichia coli,
66 (24.9%) Klebsiella spp. and 14 (5.28%) Proteus spp. Nonfermentative Pseudomonas spp were isolated from 8.9% cases.
Amongst the Gram negative isolates tested, 78 (21.8%) formed
extended spectrum beta-lactamases. Of the total 358 isolates
tested, 338 (94.4%) were found to be susceptible to fosfomycin.
Conclusion: Fosfomycin showed good activity against both
ESBL-producing and ESBL-negative E. coli isolates. The
main finding of our study is that fosfomycin exhibits excellent
antimicrobial activity even against the isolates with relatively high
levels of antimicrobial resistance and hence can be a useful drug
in our armamentarium. |
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ISSN: | 2249-782X 0973-709X |