Coagulation Factor XIII-A A614T gene Variation is Suggestive of Founder Effect in Iranian Patients with Sever Congenital Factor XIII Deficiency
<p><strong>Background: </strong>Factor XIII (FXIII) is a heterotetramer composing two subunits including FXIII-A and FXIII-B. Several common gene variations were observed in FXIII-A gene with obvious ethnic difference. This study assessed pattern of Tyr204Phe as a common FXIII-A ge...
Main Authors: | , , , , |
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Format: | Article |
Language: | English |
Published: |
Shahid Beheshti University of Medical Sciences
2015-12-01
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Series: | Journal of Cellular and Molecular Anesthesia |
Subjects: | |
Online Access: | http://journals.sbmu.ac.ir/jcma/article/view/10638 |
Summary: | <p><strong>Background: </strong>Factor XIII (FXIII) is a heterotetramer composing two subunits including FXIII-A and FXIII-B. Several common gene variations were observed in FXIII-A gene with obvious ethnic difference. This study assessed pattern of Tyr204Phe as a common FXIII-A gene variation among Iranian population.</p><p><strong>Materials and methods: </strong>This study was conducted on eighty Iranian unrelated individuals. Genotype analysis for factor XIII-A Tyr204Phe gene variation was performed for all individuals.</p><p><strong>Results: </strong>Molecular analysis of these Iranian populations revealed that all studied patients were homozygous for TGG CGG mutation at codon 187, in exon 4 of FXIII-A1 gene.</p><p><strong>Conclusion: </strong>Tyr204Phe gene variation is one of the most common mutations of FXIII-A subunit that shows a different pattern in Iranian population.</p> |
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ISSN: | 2476-5120 |