Association of the low-density lipoprotein cholesterol/high-density lipoprotein cholesterol ratio and concentrations of plasma lipids with high-density lipoprotein subclass distribution in the Chinese population
<p>Abstract</p> <p>Background</p> <p>To evaluate the relationship between the low-density lipoprotein cholesterol (LDL-C)/high-density lipoprotein cholesterol (HDL-C) ratio and HDL subclass distribution and to further examine and discuss the potential impact of LDL-C an...
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doaj-a0a9a7811c6b4d63b13a301665426a352020-11-24T22:17:22ZengBMCLipids in Health and Disease1476-511X2010-07-01916910.1186/1476-511X-9-69Association of the low-density lipoprotein cholesterol/high-density lipoprotein cholesterol ratio and concentrations of plasma lipids with high-density lipoprotein subclass distribution in the Chinese populationLong ShiyinQin YangLiu YinghuiTian LiXu YanhuaFu Mingde<p>Abstract</p> <p>Background</p> <p>To evaluate the relationship between the low-density lipoprotein cholesterol (LDL-C)/high-density lipoprotein cholesterol (HDL-C) ratio and HDL subclass distribution and to further examine and discuss the potential impact of LDL-C and HDL-C together with TG on HDL subclass metabolism.</p> <p>Results</p> <p>Small-sized preβ<sub>1</sub>-HDL, HDL<sub>3b </sub>and HDL<sub>3a </sub>increased significantly while large-sized HDL<sub>2a </sub>and HDL<sub>2b </sub>decreased significantly as the LDL-C/HDL-C ratio increased. The subjects in low HDL-C level (< 1.03 mmol/L) who had an elevation of the LDL-C/HDL-C ratio and a reduction of HDL<sub>2b</sub>/preβ<sub>1</sub>-HDL regardless of an undesirable or high LDL-C level. At desirable LDL-C levels (< 3.34 mmol/L), the HDL<sub>2b</sub>/preβ<sub>1</sub>-HDL ratio was 5.4 for the subjects with a high HDL-C concentration (≥ 1.55 mmol/L); however, at high LDL-C levels (≥ 3.36 mmol/L), the ratio of LDL-C/HDL-C was 2.8 in subjects, and an extremely low HDL<sub>2b</sub>/preβ<sub>1</sub>-HDL value although with high HDL-C concentration.</p> <p>Conclusion</p> <p>With increase of the LDL-C/HDL-C ratio, there was a general shift toward smaller-sized HDL particles, which implied that the maturation process of HDL was blocked. High HDL-C concentrations can regulate the HDL subclass distribution at desirable and borderline LDL-C levels but cannot counteract the influence of high LDL-C levels on HDL subclass distribution.</p> http://www.lipidworld.com/content/9/1/69 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Long Shiyin Qin Yang Liu Yinghui Tian Li Xu Yanhua Fu Mingde |
spellingShingle |
Long Shiyin Qin Yang Liu Yinghui Tian Li Xu Yanhua Fu Mingde Association of the low-density lipoprotein cholesterol/high-density lipoprotein cholesterol ratio and concentrations of plasma lipids with high-density lipoprotein subclass distribution in the Chinese population Lipids in Health and Disease |
author_facet |
Long Shiyin Qin Yang Liu Yinghui Tian Li Xu Yanhua Fu Mingde |
author_sort |
Long Shiyin |
title |
Association of the low-density lipoprotein cholesterol/high-density lipoprotein cholesterol ratio and concentrations of plasma lipids with high-density lipoprotein subclass distribution in the Chinese population |
title_short |
Association of the low-density lipoprotein cholesterol/high-density lipoprotein cholesterol ratio and concentrations of plasma lipids with high-density lipoprotein subclass distribution in the Chinese population |
title_full |
Association of the low-density lipoprotein cholesterol/high-density lipoprotein cholesterol ratio and concentrations of plasma lipids with high-density lipoprotein subclass distribution in the Chinese population |
title_fullStr |
Association of the low-density lipoprotein cholesterol/high-density lipoprotein cholesterol ratio and concentrations of plasma lipids with high-density lipoprotein subclass distribution in the Chinese population |
title_full_unstemmed |
Association of the low-density lipoprotein cholesterol/high-density lipoprotein cholesterol ratio and concentrations of plasma lipids with high-density lipoprotein subclass distribution in the Chinese population |
title_sort |
association of the low-density lipoprotein cholesterol/high-density lipoprotein cholesterol ratio and concentrations of plasma lipids with high-density lipoprotein subclass distribution in the chinese population |
publisher |
BMC |
series |
Lipids in Health and Disease |
issn |
1476-511X |
publishDate |
2010-07-01 |
description |
<p>Abstract</p> <p>Background</p> <p>To evaluate the relationship between the low-density lipoprotein cholesterol (LDL-C)/high-density lipoprotein cholesterol (HDL-C) ratio and HDL subclass distribution and to further examine and discuss the potential impact of LDL-C and HDL-C together with TG on HDL subclass metabolism.</p> <p>Results</p> <p>Small-sized preβ<sub>1</sub>-HDL, HDL<sub>3b </sub>and HDL<sub>3a </sub>increased significantly while large-sized HDL<sub>2a </sub>and HDL<sub>2b </sub>decreased significantly as the LDL-C/HDL-C ratio increased. The subjects in low HDL-C level (< 1.03 mmol/L) who had an elevation of the LDL-C/HDL-C ratio and a reduction of HDL<sub>2b</sub>/preβ<sub>1</sub>-HDL regardless of an undesirable or high LDL-C level. At desirable LDL-C levels (< 3.34 mmol/L), the HDL<sub>2b</sub>/preβ<sub>1</sub>-HDL ratio was 5.4 for the subjects with a high HDL-C concentration (≥ 1.55 mmol/L); however, at high LDL-C levels (≥ 3.36 mmol/L), the ratio of LDL-C/HDL-C was 2.8 in subjects, and an extremely low HDL<sub>2b</sub>/preβ<sub>1</sub>-HDL value although with high HDL-C concentration.</p> <p>Conclusion</p> <p>With increase of the LDL-C/HDL-C ratio, there was a general shift toward smaller-sized HDL particles, which implied that the maturation process of HDL was blocked. High HDL-C concentrations can regulate the HDL subclass distribution at desirable and borderline LDL-C levels but cannot counteract the influence of high LDL-C levels on HDL subclass distribution.</p> |
url |
http://www.lipidworld.com/content/9/1/69 |
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