The 3D nuclear conformation of the major histocompatibility complex changes upon cell activation both in porcine and human macrophages

The 3D nuclear conformation of the major histocompatibility complex changes upon cell activation both in porcine and human macrophages

Abstract Background The crucial role of the major histocompatibility complex (MHC) for the immune response to infectious diseases is well-known, but no information is available on the 3D nuclear organization of this gene-dense region in immune cells, whereas nuclear architecture is known to play an...

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Bibliographic Details
Main Authors: Florence Mompart, Alain Kamgoué, Yvette Lahbib-Mansais, David Robelin, Agnès Bonnet, Claire Rogel-Gaillard, Silvia Kocanova, Martine Yerle-Bouissou
Format: Article
Language:English
Published: BMC 2021-09-01
Series:BMC Molecular and Cell Biology
Subjects:
Nuclear architecture
Gene expression
Major histocompatibility complex
Macrophage
LPS/IFNγ activation
3D-FISH
Online Access:https://doi.org/10.1186/s12860-021-00384-4

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