Detection of Circulating Tumor Cells

Detection of Circulating Tumor Cells

The increasing number of treatment options for patients with metastatic carcinomas has created an accompanying need for methods to determine if the tumor will be responsive to the intended therapy and to monitor its effectiveness. Ideally, these methods would be noninvasive and provide quantitative...

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Main Authors: Sanne de Wit, Guus van Dalum, Leon W. M. M. Terstappen
Format: Article
Language:English
Published: Hindawi Limited 2014-01-01
Series:Scientifica
Online Access:http://dx.doi.org/10.1155/2014/819362
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spelling doaj-a0b7600adb814173b4b109fc290197c52020-11-25T01:13:04ZengHindawi LimitedScientifica2090-908X2014-01-01201410.1155/2014/819362819362Detection of Circulating Tumor CellsSanne de Wit0Guus van Dalum1Leon W. M. M. Terstappen2Department of Medical Cell BioPhysics, Faculty of Science and Technology, MIRA Institute for Biomedical Technology and Technical Medicine, University of Twente, Carre, Room C4437, Hallenweg 23, 7522 NH Enschede, The NetherlandsDepartment of Medical Cell BioPhysics, Faculty of Science and Technology, MIRA Institute for Biomedical Technology and Technical Medicine, University of Twente, Carre, Room C4437, Hallenweg 23, 7522 NH Enschede, The NetherlandsDepartment of Medical Cell BioPhysics, Faculty of Science and Technology, MIRA Institute for Biomedical Technology and Technical Medicine, University of Twente, Carre, Room C4437, Hallenweg 23, 7522 NH Enschede, The NetherlandsThe increasing number of treatment options for patients with metastatic carcinomas has created an accompanying need for methods to determine if the tumor will be responsive to the intended therapy and to monitor its effectiveness. Ideally, these methods would be noninvasive and provide quantitative real-time analysis of tumor activity in a variety of carcinomas. Assessment of circulating tumor cells shed into the blood during metastasis may satisfy this need. Here we review the CellSearch technology used for the detection of circulating tumor cells and discuss potential future directions for improvements.http://dx.doi.org/10.1155/2014/819362
collection DOAJ
language English
format Article
sources DOAJ
author Sanne de Wit
Guus van Dalum
Leon W. M. M. Terstappen
spellingShingle Sanne de Wit
Guus van Dalum
Leon W. M. M. Terstappen
Detection of Circulating Tumor Cells
Scientifica
author_facet Sanne de Wit
Guus van Dalum
Leon W. M. M. Terstappen
author_sort Sanne de Wit
title Detection of Circulating Tumor Cells
title_short Detection of Circulating Tumor Cells
title_full Detection of Circulating Tumor Cells
title_fullStr Detection of Circulating Tumor Cells
title_full_unstemmed Detection of Circulating Tumor Cells
title_sort detection of circulating tumor cells
publisher Hindawi Limited
series Scientifica
issn 2090-908X
publishDate 2014-01-01
description The increasing number of treatment options for patients with metastatic carcinomas has created an accompanying need for methods to determine if the tumor will be responsive to the intended therapy and to monitor its effectiveness. Ideally, these methods would be noninvasive and provide quantitative real-time analysis of tumor activity in a variety of carcinomas. Assessment of circulating tumor cells shed into the blood during metastasis may satisfy this need. Here we review the CellSearch technology used for the detection of circulating tumor cells and discuss potential future directions for improvements.
url http://dx.doi.org/10.1155/2014/819362
work_keys_str_mv AT sannedewit detectionofcirculatingtumorcells
AT guusvandalum detectionofcirculatingtumorcells
AT leonwmmterstappen detectionofcirculatingtumorcells
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