<i>Vitis vinifera</i> L. Leaf Extract Inhibits In Vitro Mediators of Inflammation and Oxidative Stress Involved in Inflammatory-Based Skin Diseases
Psoriasis is a chronic cutaneous condition characterized by the release of pro-inflammatory mediators and oxidative stress. The reduction of these factors is currently the most effective strategy to inhibit the symptoms of pathology. Antioxidants from natural sources are increasingly used to improve...
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doaj-a0b8c94b906d4627b310c2bb86bb9a0a2020-11-25T01:06:03ZengMDPI AGAntioxidants2076-39212019-05-018513410.3390/antiox8050134antiox8050134<i>Vitis vinifera</i> L. Leaf Extract Inhibits In Vitro Mediators of Inflammation and Oxidative Stress Involved in Inflammatory-Based Skin DiseasesEnrico Sangiovanni0Chiara Di Lorenzo1Stefano Piazza2Yuri Manzoni3Cecilia Brunelli4Marco Fumagalli5Andrea Magnavacca6Giulia Martinelli7Francesca Colombo8Antonella Casiraghi9Gloria Melzi10Laura Marabini11Patrizia Restani12Mario Dell’Agli13Department of Pharmacological and Biomolecular Sciences, Università degli Studi di Milano, 20133 Milan, ItalyDepartment of Pharmacological and Biomolecular Sciences, Università degli Studi di Milano, 20133 Milan, ItalyDepartment of Pharmacological and Biomolecular Sciences, Università degli Studi di Milano, 20133 Milan, ItalyDepartment of Pharmacological and Biomolecular Sciences, Università degli Studi di Milano, 20133 Milan, ItalyDepartment of Pharmacological and Biomolecular Sciences, Università degli Studi di Milano, 20133 Milan, ItalyDepartment of Pharmacological and Biomolecular Sciences, Università degli Studi di Milano, 20133 Milan, ItalyDepartment of Pharmacological and Biomolecular Sciences, Università degli Studi di Milano, 20133 Milan, ItalyDepartment of Pharmacological and Biomolecular Sciences, Università degli Studi di Milano, 20133 Milan, ItalyDepartment of Pharmacological and Biomolecular Sciences, Università degli Studi di Milano, 20133 Milan, ItalyDepartment of Pharmaceutical Sciences, Università degli Studi di Milano, 20133 Milan, ItalyDepartment of Pharmacological and Biomolecular Sciences, Università degli Studi di Milano, 20133 Milan, ItalyDepartment Environmental Science and Policy, Università degli Studi di Milano, 20133 Milan, ItalyDepartment of Pharmacological and Biomolecular Sciences, Università degli Studi di Milano, 20133 Milan, ItalyDepartment of Pharmacological and Biomolecular Sciences, Università degli Studi di Milano, 20133 Milan, ItalyPsoriasis is a chronic cutaneous condition characterized by the release of pro-inflammatory mediators and oxidative stress. The reduction of these factors is currently the most effective strategy to inhibit the symptoms of pathology. Antioxidants from natural sources are increasingly used to improve skin conditions. Dried red leaves from grapevine (<i>Vitis vinifera</i> L., cv Teinturiers) showed anti-inflammatory and anti-bacterial activities, but their possible effects on keratinocytes have not been previously investigated. In this study we tested the ability of a water extract from grapevine leaves (VVWE) to inhibit inflammatory conditions in human keratinocytes (HaCaT cells), challenged with proinflammatory (tumor necrosis factor-α (TNF-α) or lipopolysaccharide (LPS)) or prooxidant (ultraviolet B radiation (UVB) or H<sub>2</sub>O<sub>2</sub>) mediators. VVWE inhibited interleukin-8 (IL-8) secretion induced by proinflammatory stimuli, acting on the IL-8 promoter activity, but the effect was lower when prooxidant mediators were used. The effect was partly explained by the reduction of nuclear factor-κB (NF-κB)-driven transcription and nuclear translocation. Furthermore, vascular endothelial growth factor (VEGF) secretion, a regulator of angiogenesis, was inhibited by VVWE, but not matrix metalloproteinase-9 (MMP-9), a protease involved in matrix remodeling. VVWE, assayed on Franz diffusion cell system, showed a marked reduction of High Performance Liquid Chromatography (HPLC)-identified compounds. Pure molecules individually failed to reduce TNF-α-induced IL-8 release, suggesting synergistic effects or the presence of other bioactive compounds still unknown.https://www.mdpi.com/2076-3921/8/5/134<i>Vitis vinifera</i> L.grapevine leaveskeratinocytesskin inflammationoxidative stressin vitro skin permeabilityTNF-αUVBLPSH<sub>2</sub>O<sub>2</sub> |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Enrico Sangiovanni Chiara Di Lorenzo Stefano Piazza Yuri Manzoni Cecilia Brunelli Marco Fumagalli Andrea Magnavacca Giulia Martinelli Francesca Colombo Antonella Casiraghi Gloria Melzi Laura Marabini Patrizia Restani Mario Dell’Agli |
spellingShingle |
Enrico Sangiovanni Chiara Di Lorenzo Stefano Piazza Yuri Manzoni Cecilia Brunelli Marco Fumagalli Andrea Magnavacca Giulia Martinelli Francesca Colombo Antonella Casiraghi Gloria Melzi Laura Marabini Patrizia Restani Mario Dell’Agli <i>Vitis vinifera</i> L. Leaf Extract Inhibits In Vitro Mediators of Inflammation and Oxidative Stress Involved in Inflammatory-Based Skin Diseases Antioxidants <i>Vitis vinifera</i> L. grapevine leaves keratinocytes skin inflammation oxidative stress in vitro skin permeability TNF-α UVB LPS H<sub>2</sub>O<sub>2</sub> |
author_facet |
Enrico Sangiovanni Chiara Di Lorenzo Stefano Piazza Yuri Manzoni Cecilia Brunelli Marco Fumagalli Andrea Magnavacca Giulia Martinelli Francesca Colombo Antonella Casiraghi Gloria Melzi Laura Marabini Patrizia Restani Mario Dell’Agli |
author_sort |
Enrico Sangiovanni |
title |
<i>Vitis vinifera</i> L. Leaf Extract Inhibits In Vitro Mediators of Inflammation and Oxidative Stress Involved in Inflammatory-Based Skin Diseases |
title_short |
<i>Vitis vinifera</i> L. Leaf Extract Inhibits In Vitro Mediators of Inflammation and Oxidative Stress Involved in Inflammatory-Based Skin Diseases |
title_full |
<i>Vitis vinifera</i> L. Leaf Extract Inhibits In Vitro Mediators of Inflammation and Oxidative Stress Involved in Inflammatory-Based Skin Diseases |
title_fullStr |
<i>Vitis vinifera</i> L. Leaf Extract Inhibits In Vitro Mediators of Inflammation and Oxidative Stress Involved in Inflammatory-Based Skin Diseases |
title_full_unstemmed |
<i>Vitis vinifera</i> L. Leaf Extract Inhibits In Vitro Mediators of Inflammation and Oxidative Stress Involved in Inflammatory-Based Skin Diseases |
title_sort |
<i>vitis vinifera</i> l. leaf extract inhibits in vitro mediators of inflammation and oxidative stress involved in inflammatory-based skin diseases |
publisher |
MDPI AG |
series |
Antioxidants |
issn |
2076-3921 |
publishDate |
2019-05-01 |
description |
Psoriasis is a chronic cutaneous condition characterized by the release of pro-inflammatory mediators and oxidative stress. The reduction of these factors is currently the most effective strategy to inhibit the symptoms of pathology. Antioxidants from natural sources are increasingly used to improve skin conditions. Dried red leaves from grapevine (<i>Vitis vinifera</i> L., cv Teinturiers) showed anti-inflammatory and anti-bacterial activities, but their possible effects on keratinocytes have not been previously investigated. In this study we tested the ability of a water extract from grapevine leaves (VVWE) to inhibit inflammatory conditions in human keratinocytes (HaCaT cells), challenged with proinflammatory (tumor necrosis factor-α (TNF-α) or lipopolysaccharide (LPS)) or prooxidant (ultraviolet B radiation (UVB) or H<sub>2</sub>O<sub>2</sub>) mediators. VVWE inhibited interleukin-8 (IL-8) secretion induced by proinflammatory stimuli, acting on the IL-8 promoter activity, but the effect was lower when prooxidant mediators were used. The effect was partly explained by the reduction of nuclear factor-κB (NF-κB)-driven transcription and nuclear translocation. Furthermore, vascular endothelial growth factor (VEGF) secretion, a regulator of angiogenesis, was inhibited by VVWE, but not matrix metalloproteinase-9 (MMP-9), a protease involved in matrix remodeling. VVWE, assayed on Franz diffusion cell system, showed a marked reduction of High Performance Liquid Chromatography (HPLC)-identified compounds. Pure molecules individually failed to reduce TNF-α-induced IL-8 release, suggesting synergistic effects or the presence of other bioactive compounds still unknown. |
topic |
<i>Vitis vinifera</i> L. grapevine leaves keratinocytes skin inflammation oxidative stress in vitro skin permeability TNF-α UVB LPS H<sub>2</sub>O<sub>2</sub> |
url |
https://www.mdpi.com/2076-3921/8/5/134 |
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