Neutral Sphingomyelinase Behaviour in Hippocampus Neuroinflammation of MPTP-Induced Mouse Model of Parkinson’s Disease and in Embryonic Hippocampal Cells
Neutral sphingomyelinase is known to be implicated in growth arrest, differentiation, proliferation, and apoptosis. Although previous studies have reported the involvement of neutral sphingomyelinase in hippocampus physiopathology, its behavior in the hippocampus during Parkinson’s disease remains u...
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2017-01-01
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Series: | Mediators of Inflammation |
Online Access: | http://dx.doi.org/10.1155/2017/2470950 |
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doaj-a0b990265f6f490299c46bc3891038a82020-11-24T23:31:19ZengHindawi LimitedMediators of Inflammation0962-93511466-18612017-01-01201710.1155/2017/24709502470950Neutral Sphingomyelinase Behaviour in Hippocampus Neuroinflammation of MPTP-Induced Mouse Model of Parkinson’s Disease and in Embryonic Hippocampal CellsSamuela Cataldi0Cataldo Arcuri1Stéphane Hunot2François-Pierre Légeron3Carmen Mecca4Mercedes Garcia-Gil5Andrea Lazzarini6Michela Codini7Tommaso Beccari8Anna Tasegian9Bernard Fioretti10Giovanna Traina11Francesco Saverio Ambesi-Impiombato12Francesco Curcio13Elisabetta Albi14Department of Pharmaceutical Science, University of Perugia, Perugia, ItalyDepartment of Experimental Medicine, University of Perugia, Polo Unico Sant’Andrea delle Fratte, Piazzale Gambuli, 06132 Perugia, ItalyInserm U 1127, CNRS UMR 7225, Sorbonne Universités, UPMC Univ Paris 06 UMR S 1127, Institut du Cerveau et de la Moelleépinière (ICM), 75013 Paris, FranceInserm U 1127, CNRS UMR 7225, Sorbonne Universités, UPMC Univ Paris 06 UMR S 1127, Institut du Cerveau et de la Moelleépinière (ICM), 75013 Paris, FranceDepartment of Experimental Medicine, University of Perugia, Polo Unico Sant’Andrea delle Fratte, Piazzale Gambuli, 06132 Perugia, ItalyDepartment of Biology and Interdepartmental Research Center Nutrafood “Nutraceuticals and Food for Health”, University of Pisa, Pisa, ItalyCRABiON-Perugia, Via Ponchielli 4, 06073 Perugia, ItalyDepartment of Pharmaceutical Science, University of Perugia, Perugia, ItalyDepartment of Pharmaceutical Science, University of Perugia, Perugia, ItalyDepartment of Pharmaceutical Science, University of Perugia, Perugia, ItalyDepartment of Chemistry, Biology and Biotechnology, Via Elce di sotto, 06123 Perugia, ItalyDepartment of Pharmaceutical Science, University of Perugia, Perugia, ItalyDipartimento di Area Medica (DAME), University of Udine, P.le M. Kolbe 4, 33100 Udine, ItalyDipartimento di Area Medica (DAME), University of Udine, P.le M. Kolbe 4, 33100 Udine, ItalyDepartment of Pharmaceutical Science, University of Perugia, Perugia, ItalyNeutral sphingomyelinase is known to be implicated in growth arrest, differentiation, proliferation, and apoptosis. Although previous studies have reported the involvement of neutral sphingomyelinase in hippocampus physiopathology, its behavior in the hippocampus during Parkinson’s disease remains undetected. In this study, we show an upregulation of inducible nitric oxide synthase and a downregulation of neutral sphingomyelinase in the hippocampus of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine- (MPTP-) induced mouse model of Parkinson’s disease. Moreover, the stimulation of neutral sphingomyelinase activity with vitamin 1,25-dihydroxyvitamin D3 reduces specifically saturated fatty acid sphingomyelin by making sphingomyelin a less rigid molecule that might influence neurite plasticity. The possible biological relevance of the increase of neutral sphingomyelinase in Parkinson’s disease is discussed.http://dx.doi.org/10.1155/2017/2470950 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Samuela Cataldi Cataldo Arcuri Stéphane Hunot François-Pierre Légeron Carmen Mecca Mercedes Garcia-Gil Andrea Lazzarini Michela Codini Tommaso Beccari Anna Tasegian Bernard Fioretti Giovanna Traina Francesco Saverio Ambesi-Impiombato Francesco Curcio Elisabetta Albi |
spellingShingle |
Samuela Cataldi Cataldo Arcuri Stéphane Hunot François-Pierre Légeron Carmen Mecca Mercedes Garcia-Gil Andrea Lazzarini Michela Codini Tommaso Beccari Anna Tasegian Bernard Fioretti Giovanna Traina Francesco Saverio Ambesi-Impiombato Francesco Curcio Elisabetta Albi Neutral Sphingomyelinase Behaviour in Hippocampus Neuroinflammation of MPTP-Induced Mouse Model of Parkinson’s Disease and in Embryonic Hippocampal Cells Mediators of Inflammation |
author_facet |
Samuela Cataldi Cataldo Arcuri Stéphane Hunot François-Pierre Légeron Carmen Mecca Mercedes Garcia-Gil Andrea Lazzarini Michela Codini Tommaso Beccari Anna Tasegian Bernard Fioretti Giovanna Traina Francesco Saverio Ambesi-Impiombato Francesco Curcio Elisabetta Albi |
author_sort |
Samuela Cataldi |
title |
Neutral Sphingomyelinase Behaviour in Hippocampus Neuroinflammation of MPTP-Induced Mouse Model of Parkinson’s Disease and in Embryonic Hippocampal Cells |
title_short |
Neutral Sphingomyelinase Behaviour in Hippocampus Neuroinflammation of MPTP-Induced Mouse Model of Parkinson’s Disease and in Embryonic Hippocampal Cells |
title_full |
Neutral Sphingomyelinase Behaviour in Hippocampus Neuroinflammation of MPTP-Induced Mouse Model of Parkinson’s Disease and in Embryonic Hippocampal Cells |
title_fullStr |
Neutral Sphingomyelinase Behaviour in Hippocampus Neuroinflammation of MPTP-Induced Mouse Model of Parkinson’s Disease and in Embryonic Hippocampal Cells |
title_full_unstemmed |
Neutral Sphingomyelinase Behaviour in Hippocampus Neuroinflammation of MPTP-Induced Mouse Model of Parkinson’s Disease and in Embryonic Hippocampal Cells |
title_sort |
neutral sphingomyelinase behaviour in hippocampus neuroinflammation of mptp-induced mouse model of parkinson’s disease and in embryonic hippocampal cells |
publisher |
Hindawi Limited |
series |
Mediators of Inflammation |
issn |
0962-9351 1466-1861 |
publishDate |
2017-01-01 |
description |
Neutral sphingomyelinase is known to be implicated in growth arrest, differentiation, proliferation, and apoptosis. Although previous studies have reported the involvement of neutral sphingomyelinase in hippocampus physiopathology, its behavior in the hippocampus during Parkinson’s disease remains undetected. In this study, we show an upregulation of inducible nitric oxide synthase and a downregulation of neutral sphingomyelinase in the hippocampus of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine- (MPTP-) induced mouse model of Parkinson’s disease. Moreover, the stimulation of neutral sphingomyelinase activity with vitamin 1,25-dihydroxyvitamin D3 reduces specifically saturated fatty acid sphingomyelin by making sphingomyelin a less rigid molecule that might influence neurite plasticity. The possible biological relevance of the increase of neutral sphingomyelinase in Parkinson’s disease is discussed. |
url |
http://dx.doi.org/10.1155/2017/2470950 |
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