The Impact of the Ubiquitin System in the Pathogenesis of Squamous Cell Carcinomas

The Impact of the Ubiquitin System in the Pathogenesis of Squamous Cell Carcinomas

The ubiquitin system is a dynamic regulatory pathway controlling the activity, subcellular localization and stability of a myriad of cellular proteins, which in turn affects cellular homeostasis through the regulation of a variety of signaling cascades. Aberrant activity of key components of the ubi...

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Main Authors: Veronica Gatti, Francesca Bernassola, Claudio Talora, Gerry Melino, Angelo Peschiaroli
Format: Article
Language:English
Published: MDPI AG 2020-06-01
Series:Cancers
Subjects:
squamous cell carcinoma
E3 ubiquitin ligase
deubiquitinating enzymes
oncogenes
tumor suppressor
Online Access:https://www.mdpi.com/2072-6694/12/6/1595
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spelling doaj-a0bcc58832af459ca501d9279c644cac2020-11-25T02:23:45ZengMDPI AGCancers2072-66942020-06-01121595159510.3390/cancers12061595The Impact of the Ubiquitin System in the Pathogenesis of Squamous Cell CarcinomasVeronica Gatti0Francesca Bernassola1Claudio Talora2Gerry Melino3Angelo Peschiaroli4National Research Council of Italy, Institute of Translational Pharmacology, 00133 Rome, ItalyDepartment of Experimental Medicine, TOR, University of Rome Tor Vergata, 00133 Rome, ItalyDepartment of Molecular Medicine, Sapienza University of Rome, 00185 Rome, ItalyDepartment of Experimental Medicine, TOR, University of Rome Tor Vergata, 00133 Rome, ItalyNational Research Council of Italy, Institute of Translational Pharmacology, 00133 Rome, ItalyThe ubiquitin system is a dynamic regulatory pathway controlling the activity, subcellular localization and stability of a myriad of cellular proteins, which in turn affects cellular homeostasis through the regulation of a variety of signaling cascades. Aberrant activity of key components of the ubiquitin system has been functionally linked with numerous human diseases including the initiation and progression of human tumors. In this review, we will contextualize the importance of the two main components of the ubiquitin system, the E3 ubiquitin ligases (E3s) and deubiquitinating enzymes (DUBs), in the etiology of squamous cell carcinomas (SCCs). We will discuss the signaling pathways regulated by these enzymes, emphasizing the genetic and molecular determinants underlying their deregulation in SCCs.https://www.mdpi.com/2072-6694/12/6/1595squamous cell carcinomaE3 ubiquitin ligasedeubiquitinating enzymesoncogenestumor suppressor
collection DOAJ
language English
format Article
sources DOAJ
author Veronica Gatti
Francesca Bernassola
Claudio Talora
Gerry Melino
Angelo Peschiaroli
spellingShingle Veronica Gatti
Francesca Bernassola
Claudio Talora
Gerry Melino
Angelo Peschiaroli
The Impact of the Ubiquitin System in the Pathogenesis of Squamous Cell Carcinomas
Cancers
squamous cell carcinoma
E3 ubiquitin ligase
deubiquitinating enzymes
oncogenes
tumor suppressor
author_facet Veronica Gatti
Francesca Bernassola
Claudio Talora
Gerry Melino
Angelo Peschiaroli
author_sort Veronica Gatti
title The Impact of the Ubiquitin System in the Pathogenesis of Squamous Cell Carcinomas
title_short The Impact of the Ubiquitin System in the Pathogenesis of Squamous Cell Carcinomas
title_full The Impact of the Ubiquitin System in the Pathogenesis of Squamous Cell Carcinomas
title_fullStr The Impact of the Ubiquitin System in the Pathogenesis of Squamous Cell Carcinomas
title_full_unstemmed The Impact of the Ubiquitin System in the Pathogenesis of Squamous Cell Carcinomas
title_sort impact of the ubiquitin system in the pathogenesis of squamous cell carcinomas
publisher MDPI AG
series Cancers
issn 2072-6694
publishDate 2020-06-01
description The ubiquitin system is a dynamic regulatory pathway controlling the activity, subcellular localization and stability of a myriad of cellular proteins, which in turn affects cellular homeostasis through the regulation of a variety of signaling cascades. Aberrant activity of key components of the ubiquitin system has been functionally linked with numerous human diseases including the initiation and progression of human tumors. In this review, we will contextualize the importance of the two main components of the ubiquitin system, the E3 ubiquitin ligases (E3s) and deubiquitinating enzymes (DUBs), in the etiology of squamous cell carcinomas (SCCs). We will discuss the signaling pathways regulated by these enzymes, emphasizing the genetic and molecular determinants underlying their deregulation in SCCs.
topic squamous cell carcinoma
E3 ubiquitin ligase
deubiquitinating enzymes
oncogenes
tumor suppressor
url https://www.mdpi.com/2072-6694/12/6/1595
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