Topographical and Biomechanical Guidance of Electrospun Fibers for Biomedical Applications
Electrospinning is gaining increasing interest in the biomedical field as an eco-friendly and economic technique for production of random and oriented polymeric fibers. The aim of this review was to give an overview of electrospinning potentialities in the production of fibers for biomedical applica...
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doaj-a0c9253b7c54429f9265820c84a41bad2020-12-04T00:02:23ZengMDPI AGPolymers2073-43602020-12-01122896289610.3390/polym12122896Topographical and Biomechanical Guidance of Electrospun Fibers for Biomedical ApplicationsSara Ferraris0Silvia Spriano1Alessandro Calogero Scalia2Andrea Cochis3Lia Rimondini4Iriczalli Cruz-Maya5Vincenzo Guarino6Alessio Varesano7Claudia Vineis8Department of Applied Science and Technology, Politecnico di Torino, 10129 Torino, ItalyDepartment of Applied Science and Technology, Politecnico di Torino, 10129 Torino, ItalyDepartment of Health Sciences, Center for Translational Research on Autoimmune and Allergic Diseases–CAAD, Università del Piemonte Orientale UPO, 28100 Novara, ItalyDepartment of Health Sciences, Center for Translational Research on Autoimmune and Allergic Diseases–CAAD, Università del Piemonte Orientale UPO, 28100 Novara, ItalyDepartment of Health Sciences, Center for Translational Research on Autoimmune and Allergic Diseases–CAAD, Università del Piemonte Orientale UPO, 28100 Novara, ItalyInstitute for Polymers, Composites and Biomaterials (IPCB), National Research Council of Italy, Mostra d’Oltremare, Pad. 20, V. le J.F. Kennedy 54, 80125 Napoli, ItalyInstitute for Polymers, Composites and Biomaterials (IPCB), National Research Council of Italy, Mostra d’Oltremare, Pad. 20, V. le J.F. Kennedy 54, 80125 Napoli, ItalyInstitute of Intelligent Industrial Technologies and Systems for Advanced Manufacturing (STIIMA), National Research Council of Italy (CNR), Corso Giuseppe Pella 16, 13900 Biella, ItalyInstitute of Intelligent Industrial Technologies and Systems for Advanced Manufacturing (STIIMA), National Research Council of Italy (CNR), Corso Giuseppe Pella 16, 13900 Biella, ItalyElectrospinning is gaining increasing interest in the biomedical field as an eco-friendly and economic technique for production of random and oriented polymeric fibers. The aim of this review was to give an overview of electrospinning potentialities in the production of fibers for biomedical applications with a focus on the possibility to combine biomechanical and topographical stimuli. In fact, selection of the polymer and the eventual surface modification of the fibers allow selection of the proper chemical/biological signal to be administered to the cells. Moreover, a proper design of fiber orientation, dimension, and topography can give the opportunity to drive cell growth also from a spatial standpoint. At this purpose, the review contains a first introduction on potentialities of electrospinning for the obtainment of random and oriented fibers both with synthetic and natural polymers. The biological phenomena which can be guided and promoted by fibers composition and topography are in depth investigated and discussed in the second section of the paper. Finally, the recent strategies developed in the scientific community for the realization of electrospun fibers and for their surface modification for biomedical application are presented and discussed in the last section.https://www.mdpi.com/2073-4360/12/12/2896electrospinningimplantable devicestopographical guidancebiochemical guidancecontact guidancefunctionalization |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Sara Ferraris Silvia Spriano Alessandro Calogero Scalia Andrea Cochis Lia Rimondini Iriczalli Cruz-Maya Vincenzo Guarino Alessio Varesano Claudia Vineis |
spellingShingle |
Sara Ferraris Silvia Spriano Alessandro Calogero Scalia Andrea Cochis Lia Rimondini Iriczalli Cruz-Maya Vincenzo Guarino Alessio Varesano Claudia Vineis Topographical and Biomechanical Guidance of Electrospun Fibers for Biomedical Applications Polymers electrospinning implantable devices topographical guidance biochemical guidance contact guidance functionalization |
author_facet |
Sara Ferraris Silvia Spriano Alessandro Calogero Scalia Andrea Cochis Lia Rimondini Iriczalli Cruz-Maya Vincenzo Guarino Alessio Varesano Claudia Vineis |
author_sort |
Sara Ferraris |
title |
Topographical and Biomechanical Guidance of Electrospun Fibers for Biomedical Applications |
title_short |
Topographical and Biomechanical Guidance of Electrospun Fibers for Biomedical Applications |
title_full |
Topographical and Biomechanical Guidance of Electrospun Fibers for Biomedical Applications |
title_fullStr |
Topographical and Biomechanical Guidance of Electrospun Fibers for Biomedical Applications |
title_full_unstemmed |
Topographical and Biomechanical Guidance of Electrospun Fibers for Biomedical Applications |
title_sort |
topographical and biomechanical guidance of electrospun fibers for biomedical applications |
publisher |
MDPI AG |
series |
Polymers |
issn |
2073-4360 |
publishDate |
2020-12-01 |
description |
Electrospinning is gaining increasing interest in the biomedical field as an eco-friendly and economic technique for production of random and oriented polymeric fibers. The aim of this review was to give an overview of electrospinning potentialities in the production of fibers for biomedical applications with a focus on the possibility to combine biomechanical and topographical stimuli. In fact, selection of the polymer and the eventual surface modification of the fibers allow selection of the proper chemical/biological signal to be administered to the cells. Moreover, a proper design of fiber orientation, dimension, and topography can give the opportunity to drive cell growth also from a spatial standpoint. At this purpose, the review contains a first introduction on potentialities of electrospinning for the obtainment of random and oriented fibers both with synthetic and natural polymers. The biological phenomena which can be guided and promoted by fibers composition and topography are in depth investigated and discussed in the second section of the paper. Finally, the recent strategies developed in the scientific community for the realization of electrospun fibers and for their surface modification for biomedical application are presented and discussed in the last section. |
topic |
electrospinning implantable devices topographical guidance biochemical guidance contact guidance functionalization |
url |
https://www.mdpi.com/2073-4360/12/12/2896 |
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