IMPACT OF VAGAL NERVE STIMULATION ON QUALITY OF LIFE IN DRUG-RESISTANT EPILEPSY
Background and objective. Vagal nerve stimulation (VNS) represents an alternative therapy for intractable epilepsy. The aim of this study is to analyse seizure reduction and the life quality of these patients. Material and methods. We prospectively examined 28 adult patients treated with VNS that w...
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doaj-a0d2b5ebc74a4f649fd9f31d7b2ac81e2021-08-13T14:15:52ZengAmaltea Medical Publishing HouseRomanian Journal of Neurology1843-81482069-60942018-09-0117314414910.37897/RJN.2018.3.4IMPACT OF VAGAL NERVE STIMULATION ON QUALITY OF LIFE IN DRUG-RESISTANT EPILEPSYNicoleta Tohanean0Cristina Pinzaru1Luminita Mirea2Lacramioara Perju-Dumbrava3Neuroscience Department, “Iuliu Hatieganu” University of Medicine and Pharmacy, Cluj-NapocaNeuroscience Department, “Iuliu Hatieganu” University of Medicine and Pharmacy, Cluj-NapocaNeuroscience Department, “Iuliu Hatieganu” University of Medicine and Pharmacy, Cluj-NapocaNeuroscience Department, “Iuliu Hatieganu” University of Medicine and Pharmacy, Cluj-NapocaBackground and objective. Vagal nerve stimulation (VNS) represents an alternative therapy for intractable epilepsy. The aim of this study is to analyse seizure reduction and the life quality of these patients. Material and methods. We prospectively examined 28 adult patients treated with VNS that were followed-up at least 6 months after the surgery and we recorded the number of seizures and any other changes. 16 epilepsy patients completed the Quality of Life in Epilepsy-31 questionnaire (QOLIE-31). Results. Our data revealed that 64% of patients were responders with more than 50% seizure reduction. According to McHugh classifi cation of seizure freedom, 36% patients are in class I (80-100% seizure reduction), 29% class II (50-79% reduction), 21% class III (less than 50% reduction), 7% class IV (magnet benefi t only) and 7% class V (no improvement). Only 8 patients presented mild adverse effects, such as hoarseness, fatigue and cough. Life quality has improved for 68% patients. There is a strong correlation between life quality and health and a mild positive relation with the seizure reduction. Conclusions. VNS improves life quality for more than half of patients and is a therapy to consider in refractory epilepsy.http://revistemedicale.amaltea.ro/Romanian_Journal_of_NEUROLOGY/Revista_Romana_de_NEUROLOGIE-2018-Nr.3/RJN_2018_3_Art-04.pdfvagal nerve stimulationepilepsylife quality |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Nicoleta Tohanean Cristina Pinzaru Luminita Mirea Lacramioara Perju-Dumbrava |
spellingShingle |
Nicoleta Tohanean Cristina Pinzaru Luminita Mirea Lacramioara Perju-Dumbrava IMPACT OF VAGAL NERVE STIMULATION ON QUALITY OF LIFE IN DRUG-RESISTANT EPILEPSY Romanian Journal of Neurology vagal nerve stimulation epilepsy life quality |
author_facet |
Nicoleta Tohanean Cristina Pinzaru Luminita Mirea Lacramioara Perju-Dumbrava |
author_sort |
Nicoleta Tohanean |
title |
IMPACT OF VAGAL NERVE STIMULATION ON QUALITY OF LIFE IN DRUG-RESISTANT EPILEPSY |
title_short |
IMPACT OF VAGAL NERVE STIMULATION ON QUALITY OF LIFE IN DRUG-RESISTANT EPILEPSY |
title_full |
IMPACT OF VAGAL NERVE STIMULATION ON QUALITY OF LIFE IN DRUG-RESISTANT EPILEPSY |
title_fullStr |
IMPACT OF VAGAL NERVE STIMULATION ON QUALITY OF LIFE IN DRUG-RESISTANT EPILEPSY |
title_full_unstemmed |
IMPACT OF VAGAL NERVE STIMULATION ON QUALITY OF LIFE IN DRUG-RESISTANT EPILEPSY |
title_sort |
impact of vagal nerve stimulation on quality of life in drug-resistant epilepsy |
publisher |
Amaltea Medical Publishing House |
series |
Romanian Journal of Neurology |
issn |
1843-8148 2069-6094 |
publishDate |
2018-09-01 |
description |
Background and objective. Vagal nerve stimulation (VNS) represents an alternative therapy for intractable epilepsy. The aim of this study is to analyse seizure reduction and the life quality of these patients.
Material and methods. We prospectively examined 28 adult patients treated with VNS that were followed-up at least 6 months after the surgery and we recorded the number of seizures and any other changes. 16 epilepsy patients completed the Quality of Life in Epilepsy-31 questionnaire (QOLIE-31).
Results. Our data revealed that 64% of patients were responders with more than 50% seizure reduction. According to McHugh classifi cation of seizure freedom, 36% patients are in class I (80-100% seizure reduction), 29% class II (50-79% reduction), 21% class III (less than 50% reduction), 7% class IV (magnet benefi t only) and 7% class V (no improvement). Only 8 patients presented mild adverse effects, such as hoarseness, fatigue and cough. Life quality has improved for 68% patients. There is a strong correlation between life quality and health and a mild positive relation with the seizure reduction.
Conclusions. VNS improves life quality for more than half of patients and is a therapy to consider in refractory epilepsy. |
topic |
vagal nerve stimulation epilepsy life quality |
url |
http://revistemedicale.amaltea.ro/Romanian_Journal_of_NEUROLOGY/Revista_Romana_de_NEUROLOGIE-2018-Nr.3/RJN_2018_3_Art-04.pdf |
work_keys_str_mv |
AT nicoletatohanean impactofvagalnervestimulationonqualityoflifeindrugresistantepilepsy AT cristinapinzaru impactofvagalnervestimulationonqualityoflifeindrugresistantepilepsy AT luminitamirea impactofvagalnervestimulationonqualityoflifeindrugresistantepilepsy AT lacramioaraperjudumbrava impactofvagalnervestimulationonqualityoflifeindrugresistantepilepsy |
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1721208345043402752 |