Association of Initial HbA1c Level with Obesity Medical Treatment Success in Morbidly Obese Patients
Objective: Significant clinical benefits of 5-10% weight loss in obesity have been shown at the beginning to reduce comorbidities. In this study, it was investigated whether effective weight loss at the end of three months of lifestyle change and pharmacological treatment in newly diagnosed morbid...
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Format: | Article |
Language: | English |
Published: |
Dicle University Medical School
2021-06-01
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Series: | Dicle Medical Journal |
Subjects: | |
Online Access: | http://diclemedj.org/upload/sayi/81/Dicle%20Med%20J-04663.pdf |
Summary: | Objective: Significant clinical benefits of 5-10% weight loss in obesity have been shown at the beginning to reduce
comorbidities. In this study, it was investigated whether effective weight loss at the end of three months of lifestyle
change and pharmacological treatment in newly diagnosed morbidly obese patients could be predicted by basal clinical
parameters.
Methods: In this retrospecific study, anthropometric measurements, blood pressure, lipid profile, fasting glucose and
insulin levels, liver enzymes and HBA1c levels were determined before treatment after three-month lifestyle change and
pharmacological treatment of 58 newly diagnosed morbid obese patients without previously known comorbid diseases
and the results after treatment were compared. Weight loss rates were calculated according to baseline and were
grouped as <5% (group 1, n = 13), 5-10% (group 2, n = 24), and ≥10% (group 3, n = 21).
Results: While the median initial body-mass index was 42.78 kg/m2, it had regressed to 39.96 kg/m2 at the end of three
months. Median weight loss was 9 kg (interquartile range, 6–13 kg). The mean basal HBA1c level was the highest in group
3. A positive significant correlation was observed between the basal mean HBA1c level and weight loss according to
Pearson correlation analysis (rho: 0.468, p <0.001). When multivariate logistic regression analysis was created with
baseline clinical and laboratory parameters to predict more than 10% weight loss, only the basal HBA1c level was found
to be significant (Odds ratio = 5.2 [95% confidence interval 1.03–26.15], p <0.05).
Conclusions: When pharmacological treatment is given together with a three-month lifestyle change in newly diagnosed
morbid obese patients, it can be predicted that more effective weight loss may occur in those with a high initial HBA1c
level. |
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ISSN: | 1300-2945 1308-9889 |