Tryptophan Metabolism via the Kynurenine Pathway: Implications for Graft Optimization during Machine Perfusion

Tryptophan Metabolism via the Kynurenine Pathway: Implications for Graft Optimization during Machine Perfusion

Access to liver transplantation continues to be hindered by the severe organ shortage. Extended-criteria donor livers could be used to expand the donor pool but are prone to ischemia-reperfusion injury (IRI) and post-transplant graft dysfunction. Ex situ machine perfusion may be used as a platform t...

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Bibliographic Details
Main Authors: Anna Zhang, Cailah Carroll, Siavash Raigani, Negin Karimian, Viola Huang, Sonal Nagpal, Irene Beijert, Robert J. Porte, Martin Yarmush, Korkut Uygun, Heidi Yeh
Format: Article
Language:English
Published: MDPI AG 2020-06-01
Series:Journal of Clinical Medicine
Subjects:
kynurenine
tryptophan
histamine
glutathione
machine perfusion
liver transplant
Online Access:https://www.mdpi.com/2077-0383/9/6/1864

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https://www.mdpi.com/2077-0383/9/6/1864

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