Predictors of therapy failure in newly diagnosed pulmonary tuberculosis cases in Beira, Mozambique
Abstract Objective Tuberculosis (TB) remains a major global health issue, ranking in the top ten causes of death worldwide. A deep understanding of factors influencing poor treatment outcomes may allow the development of additional treatment strategies, focused on the most vulnerable groups. Aims of...
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doaj-a0e147a08e2d4a939640e5f42775ee012020-11-25T01:31:27ZengBMCBMC Research Notes1756-05002018-02-011111610.1186/s13104-018-3209-9Predictors of therapy failure in newly diagnosed pulmonary tuberculosis cases in Beira, MozambiqueDamiano Pizzol0Nicola Veronese1Claudia Marotta2Francesco Di Gennaro3Jorge Moiane4Kajal Chhaganlal5Laura Monno6Giovanni Putoto7Walter Mazzucco8Annalisa Saracino9Research Unit, Doctors with Africa-CUAMMDepartment of Medicine (DIMED)-Geriatrics Section, University of PadovaDepartment of Science for Health Promotion and Mother to Child Care “G. D’Alessandro”, University of PalermoDepartment of Infectious Diseases, University of Bari “Aldo Moro”Faculty of Health Sciences, Catholic University of Mozambique, Center for Research in Infectious DiseasesFaculty of Health Sciences, Catholic University of Mozambique, Center for Research in Infectious DiseasesDepartment of Infectious Diseases, University of Bari “Aldo Moro”Research Section, Doctors with Africa CUAMMDepartment of Science for Health Promotion and Mother to Child Care “G. D’Alessandro”, University of PalermoDepartment of Infectious Diseases, University of Bari “Aldo Moro”Abstract Objective Tuberculosis (TB) remains a major global health issue, ranking in the top ten causes of death worldwide. A deep understanding of factors influencing poor treatment outcomes may allow the development of additional treatment strategies, focused on the most vulnerable groups. Aims of the study were: (i) to evaluate the treatment outcome among TB subjects followed in an outpatient setting and (ii) to analyze factors associated with treatment failure in newly diagnosed patients with pulmonary TB in Beira, the second largest city of Mozambique. Results A total of 301 TB adult patients (32.6% females) were enrolled. Among them, 62 (20.6%) experienced a treatment failure over a 6 months follow-up. On multivariate model, being males (O.R. = 1.73; 95% CI 1.28–2.15), absence of education (O.R. = 1.85; 95% CI 1.02–2.95), monthly income under 50 dollars (O.R. = 1.74; 95% CI 1.24–2.21) and being employed (O.R. = 1.57; 95% CI 1.21–1.70), low body mass index values (O.R. = 1.42; 95% CI 1.18–1.72) and HIV status (O.R. = 1.42; 95% CI 1.10–1.78) increased the likelihood of therapy failure over 6 months of follow-up. In this study, patients who need more medical attention were young males, malnourished, with low income and low educational degree and HIV positive. These subjects were more likely to fail therapy.http://link.springer.com/article/10.1186/s13104-018-3209-9TuberculosisMozambiqueTherapy failure |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Damiano Pizzol Nicola Veronese Claudia Marotta Francesco Di Gennaro Jorge Moiane Kajal Chhaganlal Laura Monno Giovanni Putoto Walter Mazzucco Annalisa Saracino |
spellingShingle |
Damiano Pizzol Nicola Veronese Claudia Marotta Francesco Di Gennaro Jorge Moiane Kajal Chhaganlal Laura Monno Giovanni Putoto Walter Mazzucco Annalisa Saracino Predictors of therapy failure in newly diagnosed pulmonary tuberculosis cases in Beira, Mozambique BMC Research Notes Tuberculosis Mozambique Therapy failure |
author_facet |
Damiano Pizzol Nicola Veronese Claudia Marotta Francesco Di Gennaro Jorge Moiane Kajal Chhaganlal Laura Monno Giovanni Putoto Walter Mazzucco Annalisa Saracino |
author_sort |
Damiano Pizzol |
title |
Predictors of therapy failure in newly diagnosed pulmonary tuberculosis cases in Beira, Mozambique |
title_short |
Predictors of therapy failure in newly diagnosed pulmonary tuberculosis cases in Beira, Mozambique |
title_full |
Predictors of therapy failure in newly diagnosed pulmonary tuberculosis cases in Beira, Mozambique |
title_fullStr |
Predictors of therapy failure in newly diagnosed pulmonary tuberculosis cases in Beira, Mozambique |
title_full_unstemmed |
Predictors of therapy failure in newly diagnosed pulmonary tuberculosis cases in Beira, Mozambique |
title_sort |
predictors of therapy failure in newly diagnosed pulmonary tuberculosis cases in beira, mozambique |
publisher |
BMC |
series |
BMC Research Notes |
issn |
1756-0500 |
publishDate |
2018-02-01 |
description |
Abstract Objective Tuberculosis (TB) remains a major global health issue, ranking in the top ten causes of death worldwide. A deep understanding of factors influencing poor treatment outcomes may allow the development of additional treatment strategies, focused on the most vulnerable groups. Aims of the study were: (i) to evaluate the treatment outcome among TB subjects followed in an outpatient setting and (ii) to analyze factors associated with treatment failure in newly diagnosed patients with pulmonary TB in Beira, the second largest city of Mozambique. Results A total of 301 TB adult patients (32.6% females) were enrolled. Among them, 62 (20.6%) experienced a treatment failure over a 6 months follow-up. On multivariate model, being males (O.R. = 1.73; 95% CI 1.28–2.15), absence of education (O.R. = 1.85; 95% CI 1.02–2.95), monthly income under 50 dollars (O.R. = 1.74; 95% CI 1.24–2.21) and being employed (O.R. = 1.57; 95% CI 1.21–1.70), low body mass index values (O.R. = 1.42; 95% CI 1.18–1.72) and HIV status (O.R. = 1.42; 95% CI 1.10–1.78) increased the likelihood of therapy failure over 6 months of follow-up. In this study, patients who need more medical attention were young males, malnourished, with low income and low educational degree and HIV positive. These subjects were more likely to fail therapy. |
topic |
Tuberculosis Mozambique Therapy failure |
url |
http://link.springer.com/article/10.1186/s13104-018-3209-9 |
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