Chikungunya outbreak in Bangladesh (2017): Clinical and hematological findings.
INTRODUCTION:A massive outbreak of chikungunya virus (CHIKV) occurred in Bangladesh during the period of April-September 2017, and over two million people were at risk of getting infected by the virus. A prospective cohort of viremic patients was constituted and analyzed to define the clinical, hema...
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doaj-a0e1570da5364ebe8a7404f5aec82ad42021-03-03T07:54:25ZengPublic Library of Science (PLoS)PLoS Neglected Tropical Diseases1935-27271935-27352020-02-01142e000746610.1371/journal.pntd.0007466Chikungunya outbreak in Bangladesh (2017): Clinical and hematological findings.Saeed AnwarSaeed AnwarJarin Taslem MourosiMd Fahim KhanMohammad Ohid UllahOlivier M VanakkerMohammad Jakir HosenINTRODUCTION:A massive outbreak of chikungunya virus (CHIKV) occurred in Bangladesh during the period of April-September 2017, and over two million people were at risk of getting infected by the virus. A prospective cohort of viremic patients was constituted and analyzed to define the clinical, hematological, and long-term aspects of this outbreak. METHODS:A 35-day long comprehensive survey was conducted in two major, neighboring cities, Dhaka and Mymensingh. One-hundred and eighty-seven laboratory-confirmed CHIKV cases were enrolled in the cross-sectional cohort study. Additionally, a smaller group of 48 chikungunya patients was monitored for post-infection effects for 12 months. RESULTS:Clinical data revealed that a combination of fever and arthralgia (oligoarthralgia and/or polyarthralgia) was the cardinal hallmark (97.9% of cases) of the infection. Hematological analysis showed that irrespective of age and sex groups, CHIKV patients had a decreased level of hemoglobin (n = 64, p < 0.01) and elevated erythrocyte sedimentation rate (n = 131, p < 0.01). Besides, a significant portion of the patients represented abnormal values for RBC (n = 38, p = 0.0005) and WBC (n = 63, p < 0.01) counts. The post-infection study revealed that children had an early recovery from the infection compared to the adults. Moreover, post-infection weakness, successive relapse of arthralgic pain, and memory problems were the most significant aftereffects, which had an impact on the daily activities of patients. CONCLUSIONS:This study represents a comprehensive overview of clinical and epidemiological features of the 2017 outbreak of CHIKV in Bangladesh as well as its chronic outcomes till the 12th month. It provides insights into the natural history of this disease, which may help to improve the management of CHIKV patients.https://doi.org/10.1371/journal.pntd.0007466 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Saeed Anwar Saeed Anwar Jarin Taslem Mourosi Md Fahim Khan Mohammad Ohid Ullah Olivier M Vanakker Mohammad Jakir Hosen |
spellingShingle |
Saeed Anwar Saeed Anwar Jarin Taslem Mourosi Md Fahim Khan Mohammad Ohid Ullah Olivier M Vanakker Mohammad Jakir Hosen Chikungunya outbreak in Bangladesh (2017): Clinical and hematological findings. PLoS Neglected Tropical Diseases |
author_facet |
Saeed Anwar Saeed Anwar Jarin Taslem Mourosi Md Fahim Khan Mohammad Ohid Ullah Olivier M Vanakker Mohammad Jakir Hosen |
author_sort |
Saeed Anwar |
title |
Chikungunya outbreak in Bangladesh (2017): Clinical and hematological findings. |
title_short |
Chikungunya outbreak in Bangladesh (2017): Clinical and hematological findings. |
title_full |
Chikungunya outbreak in Bangladesh (2017): Clinical and hematological findings. |
title_fullStr |
Chikungunya outbreak in Bangladesh (2017): Clinical and hematological findings. |
title_full_unstemmed |
Chikungunya outbreak in Bangladesh (2017): Clinical and hematological findings. |
title_sort |
chikungunya outbreak in bangladesh (2017): clinical and hematological findings. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS Neglected Tropical Diseases |
issn |
1935-2727 1935-2735 |
publishDate |
2020-02-01 |
description |
INTRODUCTION:A massive outbreak of chikungunya virus (CHIKV) occurred in Bangladesh during the period of April-September 2017, and over two million people were at risk of getting infected by the virus. A prospective cohort of viremic patients was constituted and analyzed to define the clinical, hematological, and long-term aspects of this outbreak. METHODS:A 35-day long comprehensive survey was conducted in two major, neighboring cities, Dhaka and Mymensingh. One-hundred and eighty-seven laboratory-confirmed CHIKV cases were enrolled in the cross-sectional cohort study. Additionally, a smaller group of 48 chikungunya patients was monitored for post-infection effects for 12 months. RESULTS:Clinical data revealed that a combination of fever and arthralgia (oligoarthralgia and/or polyarthralgia) was the cardinal hallmark (97.9% of cases) of the infection. Hematological analysis showed that irrespective of age and sex groups, CHIKV patients had a decreased level of hemoglobin (n = 64, p < 0.01) and elevated erythrocyte sedimentation rate (n = 131, p < 0.01). Besides, a significant portion of the patients represented abnormal values for RBC (n = 38, p = 0.0005) and WBC (n = 63, p < 0.01) counts. The post-infection study revealed that children had an early recovery from the infection compared to the adults. Moreover, post-infection weakness, successive relapse of arthralgic pain, and memory problems were the most significant aftereffects, which had an impact on the daily activities of patients. CONCLUSIONS:This study represents a comprehensive overview of clinical and epidemiological features of the 2017 outbreak of CHIKV in Bangladesh as well as its chronic outcomes till the 12th month. It provides insights into the natural history of this disease, which may help to improve the management of CHIKV patients. |
url |
https://doi.org/10.1371/journal.pntd.0007466 |
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