Effects of novel pyrrolomycin MP1 in MYCN amplified chemoresistant neuroblastoma cell lines alone and combined with temsirolimus

Effects of novel pyrrolomycin MP1 in MYCN amplified chemoresistant neuroblastoma cell lines alone and combined with temsirolimus

Abstract Background The activity of MP1, a pyrrolomycin, was studied in MYCN amplified neuroblastoma (NB) alone and combined with temsirolimus (TEM). Methods Activity of MP1 was tested in MYCN amplified (BE-2c, IMR) and non amplified (SKN-AS) NB cells. The effect of MP1 on MYCN, MCL-1, cleaved PARP,...

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Bibliographic Details
Main Authors: Timothy R. McGuire, Don W. Coulter, Dachang Bai, Jason A. Sughroue, Jerry Li, Zunhua Yang, Zhen Qiao, Yan Liu, Daryl J. Murry, Yashpal S. Chhonker, Erin M. McIntyre, Gracey Alexander, John G. Sharp, Rongshi Li
Format: Article
Language:English
Published: BMC 2019-08-01
Series:BMC Cancer
Subjects:
Pyrrolomycin Marinopyrrole (MP1)
Temsirolimus
Neuroblastoma
MYCN
Metabolism
Mitochondria
Online Access:http://link.springer.com/article/10.1186/s12885-019-6033-2

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