Development of a fluorogenic small substrate for dipeptidyl peptidase-4

Development of a fluorogenic small substrate for dipeptidyl peptidase-4

A series of aniline and m-phenylenediamine derivatives with electron-withdrawing 3,3,3-trifluoropropenyl substituents were synthesized as small and chemically stable fluorescent organic compounds. Their fluorescence performances were evaluated by converting 2,4-disubstituted aniline 1 to the non-flu...

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Bibliographic Details
Main Authors: Futa Ogawa, Masanori Takeda, Kanae Miyanaga, Keita Tani, Ryuji Yamazawa, Kiyoshi Ito, Atsushi Tarui, Kazuyuki Sato, Masaaki Omote
Format: Article
Language:English
Published: Beilstein-Institut 2017-12-01
Series:Beilstein Journal of Organic Chemistry
Subjects:
dipeptidyl peptidase-4
fluorogenic substrate
fluorometry
small fluorescent molecule
Online Access:https://doi.org/10.3762/bjoc.13.267

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