Non-eosinophilic occupational asthma due to exposure of merbau and bangkirai wood.
<p><strong>Objectives</strong>: To evaluate association between wood dust exposure and occupational asthma, and investigate immunopathogenesis behind the disease by examining IgE, CD4, and eosinophil level.</p><p><strong>Methods</strong>: Subjects diagnosed...
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doaj-a0eee34cbaf8401192dd15ca6808578f2020-11-25T03:51:06ZengDiscoverSysBali Medical Journal2089-11802302-29142017-05-016241542010.15562/bmj.v6i2.617333Non-eosinophilic occupational asthma due to exposure of merbau and bangkirai wood.Ida Bagus Ngurah Rai0Ketut Suryana1I Gusti Bagus Ngurah Artana2Ida Ayu Jasminarti Dwi Kusumawardani3Pulmonology Department, Udayana University, Bali, IndonesiaPulmonology Department, Udayana University, Bali, IndonesiaPulmonology Department, Udayana University, Bali, IndonesiaPulmonology Department, Udayana University, Bali, Indonesia<p><strong>Objectives</strong>: To evaluate association between wood dust exposure and occupational asthma, and investigate immunopathogenesis behind the disease by examining IgE, CD4, and eosinophil level.</p><p><strong>Methods</strong>: Subjects diagnosed with occupational asthma using Work Related Asthma Questionnaire and PEFR variability for two weeks. Wood dust exposure measured by personal dust sampler for two days during working time.</p><p><strong>Results</strong>: Among 104 samples, 17 % diagnosed with occupational asthma. Analysis showed that there were correlation between wood dust exposure and occupational asthma ( r) = 0,384; p = 0,000). ROC methods revealed that wood dust exposure 70,5 mg/m3/year associated with greater risk of occupational asthma, with sensitivity of 87,5 % and specificity 75 %. Wood dust exposure was significantly correlated with serum CD4 level, r 0,455, p 0,000. Eosinophil level did not correlate with CD4 level nor wood dust exposure.</p><p><strong>Conclusion</strong>: Merbau and bangkirai wood dust exposure is one of risk factor of occupational asthma. Occupational asthma due to these wood exposure is a non eosinophilic mechanism, and associated with elevated of CD4 serum level.</p>https://balimedicaljournal.org/index.php/bmj/article/view/617non-eosinophilic, asthma, merbau, bangkirai |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ida Bagus Ngurah Rai Ketut Suryana I Gusti Bagus Ngurah Artana Ida Ayu Jasminarti Dwi Kusumawardani |
spellingShingle |
Ida Bagus Ngurah Rai Ketut Suryana I Gusti Bagus Ngurah Artana Ida Ayu Jasminarti Dwi Kusumawardani Non-eosinophilic occupational asthma due to exposure of merbau and bangkirai wood. Bali Medical Journal non-eosinophilic, asthma, merbau, bangkirai |
author_facet |
Ida Bagus Ngurah Rai Ketut Suryana I Gusti Bagus Ngurah Artana Ida Ayu Jasminarti Dwi Kusumawardani |
author_sort |
Ida Bagus Ngurah Rai |
title |
Non-eosinophilic occupational asthma due to exposure of merbau and bangkirai wood. |
title_short |
Non-eosinophilic occupational asthma due to exposure of merbau and bangkirai wood. |
title_full |
Non-eosinophilic occupational asthma due to exposure of merbau and bangkirai wood. |
title_fullStr |
Non-eosinophilic occupational asthma due to exposure of merbau and bangkirai wood. |
title_full_unstemmed |
Non-eosinophilic occupational asthma due to exposure of merbau and bangkirai wood. |
title_sort |
non-eosinophilic occupational asthma due to exposure of merbau and bangkirai wood. |
publisher |
DiscoverSys |
series |
Bali Medical Journal |
issn |
2089-1180 2302-2914 |
publishDate |
2017-05-01 |
description |
<p><strong>Objectives</strong>: To evaluate association between wood dust exposure and occupational asthma, and investigate immunopathogenesis behind the disease by examining IgE, CD4, and eosinophil level.</p><p><strong>Methods</strong>: Subjects diagnosed with occupational asthma using Work Related Asthma Questionnaire and PEFR variability for two weeks. Wood dust exposure measured by personal dust sampler for two days during working time.</p><p><strong>Results</strong>: Among 104 samples, 17 % diagnosed with occupational asthma. Analysis showed that there were correlation between wood dust exposure and occupational asthma ( r) = 0,384; p = 0,000). ROC methods revealed that wood dust exposure 70,5 mg/m3/year associated with greater risk of occupational asthma, with sensitivity of 87,5 % and specificity 75 %. Wood dust exposure was significantly correlated with serum CD4 level, r 0,455, p 0,000. Eosinophil level did not correlate with CD4 level nor wood dust exposure.</p><p><strong>Conclusion</strong>: Merbau and bangkirai wood dust exposure is one of risk factor of occupational asthma. Occupational asthma due to these wood exposure is a non eosinophilic mechanism, and associated with elevated of CD4 serum level.</p> |
topic |
non-eosinophilic, asthma, merbau, bangkirai |
url |
https://balimedicaljournal.org/index.php/bmj/article/view/617 |
work_keys_str_mv |
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