Effect of Helicobacter pylori Infection on Serum Lipid Profile
Background. Some studies suggest a significant relationship between Helicobacter pylori infection and atherogenesis; but the mechanism of the relationship is almost unknown. The current study aimed at evaluating the relationship between H. pylori infection and serum lipid profile. Patients and Metho...
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Online Access: | http://dx.doi.org/10.1155/2018/6734809 |
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doaj-a0f018a5ac8c4c6093c3bdf85e6f7d092020-11-24T21:05:37ZengHindawi LimitedJournal of Lipids2090-30302090-30492018-01-01201810.1155/2018/67348096734809Effect of Helicobacter pylori Infection on Serum Lipid ProfileMohamadreza Haeri0Mahmoud Parham1Neda Habibi2Jamshid Vafaeimanesh3Department of Biochemistry, Qom University of Medical Sciences, Qom, IranClinical Research Development Center, Qom University of Medical Sciences, Qom, IranGastroenterology and Hepatology Disease Research Center, Qom University of Medical Sciences, Qom, IranGastroenterology and Hepatology Disease Research Center, Qom University of Medical Sciences, Qom, IranBackground. Some studies suggest a significant relationship between Helicobacter pylori infection and atherogenesis; but the mechanism of the relationship is almost unknown. The current study aimed at evaluating the relationship between H. pylori infection and serum lipid profile. Patients and Methods. The current study was conducted on 2573 patients, from 2008 to 2015. The serum anti-Helicobacter pylori antibody titer and serum lipid profile were assessed in the study population; data were statistically analyzed by SPSS version 16. P values < 0.05 were considered significant. Results. In the current study, 66.5% of the cases were serologically positive for H. pylori. Among male cases, the level of low density lipoprotein (LDL) was higher in patients with H. pylori infection, compared with that of the ones without the infection (P=0.03); although level of triglyceride (TG) was higher and the level of high density lipoprotein (HDL) was lower in the cases with H. pylori infection; there was no statistically significant difference between the cases with and without H. pylori infection regarding the level of HDL and TG. Among female cases, the level of TG was significantly lower in patients with H. pylori infection, compared with that of the ones without the infection (P=0.001); but there was no significant difference between the cases with and without H. pylori infection regarding the level of LDL and HDL. The mean fasting blood sugar (FBS) in the cases with H. pylori infection was significantly higher than that of the ones without the infection (P=0.04). Conclusion. According to the results of the current study, the levels of LDL and FBS were high among the male cases with H. pylori infection. However, in females with H. pylori infection the level of TG was low; hence, it seems that the atherogenicity of H. pylori affected the level of blood sugar more.http://dx.doi.org/10.1155/2018/6734809 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Mohamadreza Haeri Mahmoud Parham Neda Habibi Jamshid Vafaeimanesh |
spellingShingle |
Mohamadreza Haeri Mahmoud Parham Neda Habibi Jamshid Vafaeimanesh Effect of Helicobacter pylori Infection on Serum Lipid Profile Journal of Lipids |
author_facet |
Mohamadreza Haeri Mahmoud Parham Neda Habibi Jamshid Vafaeimanesh |
author_sort |
Mohamadreza Haeri |
title |
Effect of Helicobacter pylori Infection on Serum Lipid Profile |
title_short |
Effect of Helicobacter pylori Infection on Serum Lipid Profile |
title_full |
Effect of Helicobacter pylori Infection on Serum Lipid Profile |
title_fullStr |
Effect of Helicobacter pylori Infection on Serum Lipid Profile |
title_full_unstemmed |
Effect of Helicobacter pylori Infection on Serum Lipid Profile |
title_sort |
effect of helicobacter pylori infection on serum lipid profile |
publisher |
Hindawi Limited |
series |
Journal of Lipids |
issn |
2090-3030 2090-3049 |
publishDate |
2018-01-01 |
description |
Background. Some studies suggest a significant relationship between Helicobacter pylori infection and atherogenesis; but the mechanism of the relationship is almost unknown. The current study aimed at evaluating the relationship between H. pylori infection and serum lipid profile. Patients and Methods. The current study was conducted on 2573 patients, from 2008 to 2015. The serum anti-Helicobacter pylori antibody titer and serum lipid profile were assessed in the study population; data were statistically analyzed by SPSS version 16. P values < 0.05 were considered significant. Results. In the current study, 66.5% of the cases were serologically positive for H. pylori. Among male cases, the level of low density lipoprotein (LDL) was higher in patients with H. pylori infection, compared with that of the ones without the infection (P=0.03); although level of triglyceride (TG) was higher and the level of high density lipoprotein (HDL) was lower in the cases with H. pylori infection; there was no statistically significant difference between the cases with and without H. pylori infection regarding the level of HDL and TG. Among female cases, the level of TG was significantly lower in patients with H. pylori infection, compared with that of the ones without the infection (P=0.001); but there was no significant difference between the cases with and without H. pylori infection regarding the level of LDL and HDL. The mean fasting blood sugar (FBS) in the cases with H. pylori infection was significantly higher than that of the ones without the infection (P=0.04). Conclusion. According to the results of the current study, the levels of LDL and FBS were high among the male cases with H. pylori infection. However, in females with H. pylori infection the level of TG was low; hence, it seems that the atherogenicity of H. pylori affected the level of blood sugar more. |
url |
http://dx.doi.org/10.1155/2018/6734809 |
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