Hypothalamic miRNAs: emerging roles in energy balance control
The hypothalamus is a crucial central nervous system area controlling appetite, body weight and metabolism. It consists in multiple neuronal types that sense, integrate and generate appropriate responses to hormonal and nutritional signals partly by fine-tuning the expression of specific batteries o...
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doaj-a0f69a193920442f9591773919daa3982020-11-24T22:54:17ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2015-02-01910.3389/fnins.2015.00041130327Hypothalamic miRNAs: emerging roles in energy balance controlMarc eSchneeberger0Marc eSchneeberger1Marc eSchneeberger2Alicia G Gomez-Valades3Alicia G Gomez-Valades4Sara eRamirez5Ramon eGomis6Ramon eGomis7Ramon eGomis8Marc eClaret9Marc eClaret10Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM)Universitat de BarcelonaInstitut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM)Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM)Universitat de BarcelonaInstitut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM)The hypothalamus is a crucial central nervous system area controlling appetite, body weight and metabolism. It consists in multiple neuronal types that sense, integrate and generate appropriate responses to hormonal and nutritional signals partly by fine-tuning the expression of specific batteries of genes. However, the mechanisms regulating these neuronal gene programmes in physiology and pathophysiology are not completely understood. MicroRNAs (miRNAs) are key regulators of gene expression that recently emerged as pivotal modulators of systemic metabolism. In this article we will review current evidence indicating that miRNAs in hypothalamic neurons are also implicated in appetite and whole-body energy balance control.http://journal.frontiersin.org/Journal/10.3389/fnins.2015.00041/fullHypothalamusObesityenergy balancemiRNAmouse modelsPOMC neurons |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Marc eSchneeberger Marc eSchneeberger Marc eSchneeberger Alicia G Gomez-Valades Alicia G Gomez-Valades Sara eRamirez Ramon eGomis Ramon eGomis Ramon eGomis Marc eClaret Marc eClaret |
spellingShingle |
Marc eSchneeberger Marc eSchneeberger Marc eSchneeberger Alicia G Gomez-Valades Alicia G Gomez-Valades Sara eRamirez Ramon eGomis Ramon eGomis Ramon eGomis Marc eClaret Marc eClaret Hypothalamic miRNAs: emerging roles in energy balance control Frontiers in Neuroscience Hypothalamus Obesity energy balance miRNA mouse models POMC neurons |
author_facet |
Marc eSchneeberger Marc eSchneeberger Marc eSchneeberger Alicia G Gomez-Valades Alicia G Gomez-Valades Sara eRamirez Ramon eGomis Ramon eGomis Ramon eGomis Marc eClaret Marc eClaret |
author_sort |
Marc eSchneeberger |
title |
Hypothalamic miRNAs: emerging roles in energy balance control |
title_short |
Hypothalamic miRNAs: emerging roles in energy balance control |
title_full |
Hypothalamic miRNAs: emerging roles in energy balance control |
title_fullStr |
Hypothalamic miRNAs: emerging roles in energy balance control |
title_full_unstemmed |
Hypothalamic miRNAs: emerging roles in energy balance control |
title_sort |
hypothalamic mirnas: emerging roles in energy balance control |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Neuroscience |
issn |
1662-453X |
publishDate |
2015-02-01 |
description |
The hypothalamus is a crucial central nervous system area controlling appetite, body weight and metabolism. It consists in multiple neuronal types that sense, integrate and generate appropriate responses to hormonal and nutritional signals partly by fine-tuning the expression of specific batteries of genes. However, the mechanisms regulating these neuronal gene programmes in physiology and pathophysiology are not completely understood. MicroRNAs (miRNAs) are key regulators of gene expression that recently emerged as pivotal modulators of systemic metabolism. In this article we will review current evidence indicating that miRNAs in hypothalamic neurons are also implicated in appetite and whole-body energy balance control. |
topic |
Hypothalamus Obesity energy balance miRNA mouse models POMC neurons |
url |
http://journal.frontiersin.org/Journal/10.3389/fnins.2015.00041/full |
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