Simultaneous Voltammetric Determination of Ascorbic Acid, Paracetamol, and Caffeine Using Electrochemically Reduced Graphene-Oxide-Modified Electrode
In the present paper, graphene oxide was directly electrodeposited by means of cyclic voltammetric techniques on the glassy-carbon electrode (GCE) to obtain a reduced graphene-oxide-modified electrode (ErGO/GCE). Cyclic voltammetry (CV) and differential pulse anodic stripping voltammetry (DP-ASV) ha...
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doaj-a10b8d7cee27403eb8406614b27a9f3b2020-11-25T00:26:07ZengHindawi LimitedJournal of Nanomaterials1687-41101687-41292018-01-01201810.1155/2018/53480165348016Simultaneous Voltammetric Determination of Ascorbic Acid, Paracetamol, and Caffeine Using Electrochemically Reduced Graphene-Oxide-Modified ElectrodeNguyen Hai Phong0Tran Thanh Tam Toan1Mai Xuan Tinh2Tran Ngoc Tuyen3Tran Xuan Mau4Dinh Quang Khieu5HU-University of Sciences, Hue 530000, VietnamHU-University of Sciences, Hue 530000, VietnamHU-University of Sciences, Hue 530000, VietnamHU-University of Sciences, Hue 530000, VietnamHU-University of Sciences, Hue 530000, VietnamHU-University of Sciences, Hue 530000, VietnamIn the present paper, graphene oxide was directly electrodeposited by means of cyclic voltammetric techniques on the glassy-carbon electrode (GCE) to obtain a reduced graphene-oxide-modified electrode (ErGO/GCE). Cyclic voltammetry (CV) and differential pulse anodic stripping voltammetry (DP-ASV) had been utilized to study the electrochemical behavior of ErGO/GCE toward ascorbic acid (AA), paracetamol (PA), and caffeine (CA). Differential pulse voltammetry results show that AA, PA, and CA could be detected selectively and sensitively on ErGO/GCE with peak-to-peak separation of 312 mV and 756 mV for AA–PA and PA–CA, respectively. The factors affecting the voltammetric signals such as pH, scan rate, and interferents were addressed. The results reveal that the ErGO/GCE-modified electrode exhibits excellent electrochemical activity in the oxidation of PA, CA, and AA. The detection limits are 0.36 μM, 0.25 μM, and 0.23 μM for AA, PA and CA, respectively, suggesting that the ErGO/GCE can be utilized with high sensitivity and selectivity for the simultaneous determination of these compounds. Finally, the proposed method was successfully used to determine AA, PA, and CA in pharmaceutical preparations.http://dx.doi.org/10.1155/2018/5348016 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Nguyen Hai Phong Tran Thanh Tam Toan Mai Xuan Tinh Tran Ngoc Tuyen Tran Xuan Mau Dinh Quang Khieu |
spellingShingle |
Nguyen Hai Phong Tran Thanh Tam Toan Mai Xuan Tinh Tran Ngoc Tuyen Tran Xuan Mau Dinh Quang Khieu Simultaneous Voltammetric Determination of Ascorbic Acid, Paracetamol, and Caffeine Using Electrochemically Reduced Graphene-Oxide-Modified Electrode Journal of Nanomaterials |
author_facet |
Nguyen Hai Phong Tran Thanh Tam Toan Mai Xuan Tinh Tran Ngoc Tuyen Tran Xuan Mau Dinh Quang Khieu |
author_sort |
Nguyen Hai Phong |
title |
Simultaneous Voltammetric Determination of Ascorbic Acid, Paracetamol, and Caffeine Using Electrochemically Reduced Graphene-Oxide-Modified Electrode |
title_short |
Simultaneous Voltammetric Determination of Ascorbic Acid, Paracetamol, and Caffeine Using Electrochemically Reduced Graphene-Oxide-Modified Electrode |
title_full |
Simultaneous Voltammetric Determination of Ascorbic Acid, Paracetamol, and Caffeine Using Electrochemically Reduced Graphene-Oxide-Modified Electrode |
title_fullStr |
Simultaneous Voltammetric Determination of Ascorbic Acid, Paracetamol, and Caffeine Using Electrochemically Reduced Graphene-Oxide-Modified Electrode |
title_full_unstemmed |
Simultaneous Voltammetric Determination of Ascorbic Acid, Paracetamol, and Caffeine Using Electrochemically Reduced Graphene-Oxide-Modified Electrode |
title_sort |
simultaneous voltammetric determination of ascorbic acid, paracetamol, and caffeine using electrochemically reduced graphene-oxide-modified electrode |
publisher |
Hindawi Limited |
series |
Journal of Nanomaterials |
issn |
1687-4110 1687-4129 |
publishDate |
2018-01-01 |
description |
In the present paper, graphene oxide was directly electrodeposited by means of cyclic voltammetric techniques on the glassy-carbon electrode (GCE) to obtain a reduced graphene-oxide-modified electrode (ErGO/GCE). Cyclic voltammetry (CV) and differential pulse anodic stripping voltammetry (DP-ASV) had been utilized to study the electrochemical behavior of ErGO/GCE toward ascorbic acid (AA), paracetamol (PA), and caffeine (CA). Differential pulse voltammetry results show that AA, PA, and CA could be detected selectively and sensitively on ErGO/GCE with peak-to-peak separation of 312 mV and 756 mV for AA–PA and PA–CA, respectively. The factors affecting the voltammetric signals such as pH, scan rate, and interferents were addressed. The results reveal that the ErGO/GCE-modified electrode exhibits excellent electrochemical activity in the oxidation of PA, CA, and AA. The detection limits are 0.36 μM, 0.25 μM, and 0.23 μM for AA, PA and CA, respectively, suggesting that the ErGO/GCE can be utilized with high sensitivity and selectivity for the simultaneous determination of these compounds. Finally, the proposed method was successfully used to determine AA, PA, and CA in pharmaceutical preparations. |
url |
http://dx.doi.org/10.1155/2018/5348016 |
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