Perinatal outcomes and serological results in neonates of pregnant women seropositive to SARS-CoV-2: A cross-sectional descriptive study
Introduction SARS-CoV-2 has spread rapidly throughout the world. However, its ability to cause severe disease is not homogeneous according to sex and the different age groups. Objective To determine perinatal characteristics, morbidity, mortality, and serological results in neonates from seropo...
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doaj-a1212bdb44bd4044846a8348422a42ed2021-01-19T18:25:21ZengMedwave Estudios LimitadaMedwave0717-63840717-63842020-12-012011e8084e808410.5867/medwave.2020.11.8084Perinatal outcomes and serological results in neonates of pregnant women seropositive to SARS-CoV-2: A cross-sectional descriptive studyCarmen Dávila-Aliaga0https://orcid.org/0000-0001-9411-5703Marcos Espínola-Sánchez1https://orcid.org/0000-0002-1005-5158Elina Mendoza-Ibáñez2https://orcid.org/0000-0001-6285-4464Enrique Guevara Ríos3https://orcid.org/0000-0002-6962-2639 Elsa Torres-Marcos4https://orcid.org/0000-0002-2718-6621Rosmary Hinojosa-Pérez5https://orcid.org/0000-0002-6640-5102Ylia Espinoza-Vivas6https://orcid.org/0000-0003-3466-7236Ricardo Álvarez Carrasco7https://orcid.org/0000-0002-0987-6717Carlos Velásquez-Vásquez8https://orcid.org/0000-0001-9209-2480Luis Meza-Santibáñez9https://orcid.org/0000-0002-1817-8187Oswaldo Gonzales-Carrillo10https://orcid.org/0000-0001-9032-1542Pedro Arango-Ochante11https://orcid.org/0000-0002-3267-1904Augusto Racchumí-Vela12https://orcid.org/0000-0001-7695-1978Claudia Saldaña-Díaz13https://orcid.org/0000-0003-3117-5332Instituto Nacional Materno Perinatal, Lima, Perú; Universidad Nacional Federico Villarreal, Lima, Perú Instituto Nacional Materno Perinatal, Lima, Perú; Universidad Privada del Norte, Lima, Perú Instituto Nacional Materno Perinatal, Lima, Perú Instituto Nacional Materno Perinatal, Lima, Perú; Universidad Nacional Mayor de San Marcos, Lima, Perú Instituto Nacional Materno Perinatal, Lima, Perú Instituto Nacional Materno Perinatal, Lima, Perú Instituto Nacional Materno Perinatal, Lima, PerúInstituto Nacional Materno Perinatal, Lima, PerúInstituto Nacional Materno Perinatal, Lima, PerúInstituto Nacional Materno Perinatal, Lima, PerúInstituto Nacional Materno Perinatal, Lima, PerúInstituto Nacional Materno Perinatal, Lima, PerúInstituto Nacional Materno Perinatal, Lima, Perú Instituto Nacional Materno Perinatal, Lima, PerúIntroduction SARS-CoV-2 has spread rapidly throughout the world. However, its ability to cause severe disease is not homogeneous according to sex and the different age groups. Objective To determine perinatal characteristics, morbidity, mortality, and serological results in neonates from seropositive pregnant women to SARS-CoV-2. Methods We did a retrospective, descriptive, cross-sectional study. We included all newborns from positive pregnant women to SARS-CoV-2, between April 15 and May 10, 2020, who delivered in the National Perinatal Maternal Institute of Peru. The study extracted maternal and neonatal variables collected from the medical charts. The data were analyzed using descriptive statistics and Fischer's exact test. Results One hundred fourteen neonates were identified, 36.8% IgM/IgG positive for SARS-CoV-2, 7% IgG, and 56.2% had negative serology. The obstetric complications were premature rupture of membranes (14.9%) and preterm birth (8,8%). 8.8% of newborns had an Apgar score of less than or equal to six minutes, and of those, only one persisted after five minutes; three newborns died. There was an association between the type of maternal immunoglobulin and the serology of the newborn (p < 0.05). No association was observed between perinatal results and maternal immunoglobulin type (p > 0.05) or serological results in the newborn for SARS-CoV-2 (p > 0.05). Conclusion 43.9% of seropositive mothers' neonates to SARS-CoV-2 had a positive serological result, more frequently type IgM/IgG. 10.5% of the neonates had some morbidity, more frequent prematurity, low birth weight, and 2.6% died. Perinatal results were not associated with the type of immunoglobulin of mothers seropositive to SARS-CoV-2; similarly, perinatal results were not associated with serological results in the newborn.https://www.medwave.cl/link.cgi/Medwave/Estudios/Investigacion/8084.actsars-cov-2serologypregnancypregnancy outcomeinfantnewborn |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Carmen Dávila-Aliaga Marcos Espínola-Sánchez Elina Mendoza-Ibáñez Enrique Guevara Ríos Elsa Torres-Marcos Rosmary Hinojosa-Pérez Ylia Espinoza-Vivas Ricardo Álvarez Carrasco Carlos Velásquez-Vásquez Luis Meza-Santibáñez Oswaldo Gonzales-Carrillo Pedro Arango-Ochante Augusto Racchumí-Vela Claudia Saldaña-Díaz |
spellingShingle |
Carmen Dávila-Aliaga Marcos Espínola-Sánchez Elina Mendoza-Ibáñez Enrique Guevara Ríos Elsa Torres-Marcos Rosmary Hinojosa-Pérez Ylia Espinoza-Vivas Ricardo Álvarez Carrasco Carlos Velásquez-Vásquez Luis Meza-Santibáñez Oswaldo Gonzales-Carrillo Pedro Arango-Ochante Augusto Racchumí-Vela Claudia Saldaña-Díaz Perinatal outcomes and serological results in neonates of pregnant women seropositive to SARS-CoV-2: A cross-sectional descriptive study Medwave sars-cov-2 serology pregnancy pregnancy outcome infant newborn |
author_facet |
Carmen Dávila-Aliaga Marcos Espínola-Sánchez Elina Mendoza-Ibáñez Enrique Guevara Ríos Elsa Torres-Marcos Rosmary Hinojosa-Pérez Ylia Espinoza-Vivas Ricardo Álvarez Carrasco Carlos Velásquez-Vásquez Luis Meza-Santibáñez Oswaldo Gonzales-Carrillo Pedro Arango-Ochante Augusto Racchumí-Vela Claudia Saldaña-Díaz |
author_sort |
Carmen Dávila-Aliaga |
title |
Perinatal outcomes and serological results in neonates of pregnant women seropositive to SARS-CoV-2: A cross-sectional descriptive study |
title_short |
Perinatal outcomes and serological results in neonates of pregnant women seropositive to SARS-CoV-2: A cross-sectional descriptive study |
title_full |
Perinatal outcomes and serological results in neonates of pregnant women seropositive to SARS-CoV-2: A cross-sectional descriptive study |
title_fullStr |
Perinatal outcomes and serological results in neonates of pregnant women seropositive to SARS-CoV-2: A cross-sectional descriptive study |
title_full_unstemmed |
Perinatal outcomes and serological results in neonates of pregnant women seropositive to SARS-CoV-2: A cross-sectional descriptive study |
title_sort |
perinatal outcomes and serological results in neonates of pregnant women seropositive to sars-cov-2: a cross-sectional descriptive study |
publisher |
Medwave Estudios Limitada |
series |
Medwave |
issn |
0717-6384 0717-6384 |
publishDate |
2020-12-01 |
description |
Introduction
SARS-CoV-2 has spread rapidly throughout the world. However, its ability to cause severe disease is not homogeneous according to sex and the different age groups.
Objective
To determine perinatal characteristics, morbidity, mortality, and serological results in neonates from seropositive pregnant women to SARS-CoV-2.
Methods
We did a retrospective, descriptive, cross-sectional study. We included all newborns from positive pregnant women to SARS-CoV-2, between April 15 and May 10, 2020, who delivered in the National Perinatal Maternal Institute of Peru. The study extracted maternal and neonatal variables collected from the medical charts. The data were analyzed using descriptive statistics and Fischer's exact test.
Results
One hundred fourteen neonates were identified, 36.8% IgM/IgG positive for SARS-CoV-2, 7% IgG, and 56.2% had negative serology. The obstetric complications were premature rupture of membranes (14.9%) and preterm birth (8,8%). 8.8% of newborns had an Apgar score of less than or equal to six minutes, and of those, only one persisted after five minutes; three newborns died. There was an association between the type of maternal immunoglobulin and the serology of the newborn (p < 0.05). No association was observed between perinatal results and maternal immunoglobulin type (p > 0.05) or serological results in the newborn for SARS-CoV-2 (p > 0.05).
Conclusion
43.9% of seropositive mothers' neonates to SARS-CoV-2 had a positive serological result, more frequently type IgM/IgG. 10.5% of the neonates had some morbidity, more frequent prematurity, low birth weight, and 2.6% died. Perinatal results were not associated with the type of immunoglobulin of mothers seropositive to SARS-CoV-2; similarly, perinatal results were not associated with serological results in the newborn. |
topic |
sars-cov-2 serology pregnancy pregnancy outcome infant newborn |
url |
https://www.medwave.cl/link.cgi/Medwave/Estudios/Investigacion/8084.act |
work_keys_str_mv |
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