Impact of a Ketogenic Diet on Sporadic Inclusion Body Myositis: A Case Study
Sporadic inclusion body myositis (IBM) is a chronic inflammatory and degenerative muscle disease with limited treatment options; no therapy can alter its natural course. Ketogenic diets are theoretically capable of suppressing inflammation, enhancing cell bioenergetics, alleviating mitochondria dysf...
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doaj-a122e8297fed409da0ec5695bf65afd22020-11-25T04:03:26ZengFrontiers Media S.A.Frontiers in Neurology1664-22952020-11-011110.3389/fneur.2020.582402582402Impact of a Ketogenic Diet on Sporadic Inclusion Body Myositis: A Case StudyMatthew C. L. Phillips0Deborah K. J. Murtagh1Fouzia Ziad2Samuel E. Johnston3Ben G. Moon4Department of Neurology, Waikato Hospital, Hamilton, New ZealandHealthy Kitchen Christchurch Ltd., Hamilton, New ZealandDepartment of Pathology, Waikato Hospital, Hamilton, New ZealandDepartment of Older Persons and Rehabilitation, Waikato Hospital, Hamilton, New ZealandDepartment of Radiology, Waikato Hospital, Hamilton, New ZealandSporadic inclusion body myositis (IBM) is a chronic inflammatory and degenerative muscle disease with limited treatment options; no therapy can alter its natural course. Ketogenic diets are theoretically capable of suppressing inflammation, enhancing cell bioenergetics, alleviating mitochondria dysfunction, and stimulating autophagy, which may be beneficial in IBM. We report the case of a 52-year-old woman with worsening IBM who pursued a modified ketogenic diet for 1 year. Adverse effects were mild and resolved 3 weeks into the diet. Prior to starting her ketogenic diet, despite the use of a walking stick at all times, she was experiencing one to two falls per week as well as swallowing difficulties, musculoskeletal pain, and depression. Moreover, magnetic resonance imaging (MRI) of the bilateral thighs during the year prior to the diet indicated worsening muscle inflammation and a 14% decrease in thigh muscle volume, which corresponded to a 4% decrease in the ratio of thigh muscle to thigh total volume. After 1 year on her ketogenic diet, our patient regained independent walking, and her swallowing difficulties, pain, and depression resolved. She maintained her strength, improved in every test of function, enhanced her quality of life, and lowered her blood creatine kinase. MRI of the bilateral thighs during the year of the diet indicated stabilized muscle inflammation and a 2.9% decrease in thigh muscle volume, which in the context of diet-induced fat loss corresponded to a sustained 1% increase in the ratio of thigh muscle to thigh total volume. This case is unique in that a ketogenic diet was utilized as the primary treatment strategy for a patient with confirmed IBM, culminating in substantial clinical improvement, stabilized muscle inflammation, and a slowed rate of muscle atrophy. Our patient has remained on her ketogenic diet for over 2 years now and continues to enjoy a full and independent life.https://www.frontiersin.org/articles/10.3389/fneur.2020.582402/fullinclusion body myositisketogenic dietinflammationdegenerationmuscle |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Matthew C. L. Phillips Deborah K. J. Murtagh Fouzia Ziad Samuel E. Johnston Ben G. Moon |
spellingShingle |
Matthew C. L. Phillips Deborah K. J. Murtagh Fouzia Ziad Samuel E. Johnston Ben G. Moon Impact of a Ketogenic Diet on Sporadic Inclusion Body Myositis: A Case Study Frontiers in Neurology inclusion body myositis ketogenic diet inflammation degeneration muscle |
author_facet |
Matthew C. L. Phillips Deborah K. J. Murtagh Fouzia Ziad Samuel E. Johnston Ben G. Moon |
author_sort |
Matthew C. L. Phillips |
title |
Impact of a Ketogenic Diet on Sporadic Inclusion Body Myositis: A Case Study |
title_short |
Impact of a Ketogenic Diet on Sporadic Inclusion Body Myositis: A Case Study |
title_full |
Impact of a Ketogenic Diet on Sporadic Inclusion Body Myositis: A Case Study |
title_fullStr |
Impact of a Ketogenic Diet on Sporadic Inclusion Body Myositis: A Case Study |
title_full_unstemmed |
Impact of a Ketogenic Diet on Sporadic Inclusion Body Myositis: A Case Study |
title_sort |
impact of a ketogenic diet on sporadic inclusion body myositis: a case study |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Neurology |
issn |
1664-2295 |
publishDate |
2020-11-01 |
description |
Sporadic inclusion body myositis (IBM) is a chronic inflammatory and degenerative muscle disease with limited treatment options; no therapy can alter its natural course. Ketogenic diets are theoretically capable of suppressing inflammation, enhancing cell bioenergetics, alleviating mitochondria dysfunction, and stimulating autophagy, which may be beneficial in IBM. We report the case of a 52-year-old woman with worsening IBM who pursued a modified ketogenic diet for 1 year. Adverse effects were mild and resolved 3 weeks into the diet. Prior to starting her ketogenic diet, despite the use of a walking stick at all times, she was experiencing one to two falls per week as well as swallowing difficulties, musculoskeletal pain, and depression. Moreover, magnetic resonance imaging (MRI) of the bilateral thighs during the year prior to the diet indicated worsening muscle inflammation and a 14% decrease in thigh muscle volume, which corresponded to a 4% decrease in the ratio of thigh muscle to thigh total volume. After 1 year on her ketogenic diet, our patient regained independent walking, and her swallowing difficulties, pain, and depression resolved. She maintained her strength, improved in every test of function, enhanced her quality of life, and lowered her blood creatine kinase. MRI of the bilateral thighs during the year of the diet indicated stabilized muscle inflammation and a 2.9% decrease in thigh muscle volume, which in the context of diet-induced fat loss corresponded to a sustained 1% increase in the ratio of thigh muscle to thigh total volume. This case is unique in that a ketogenic diet was utilized as the primary treatment strategy for a patient with confirmed IBM, culminating in substantial clinical improvement, stabilized muscle inflammation, and a slowed rate of muscle atrophy. Our patient has remained on her ketogenic diet for over 2 years now and continues to enjoy a full and independent life. |
topic |
inclusion body myositis ketogenic diet inflammation degeneration muscle |
url |
https://www.frontiersin.org/articles/10.3389/fneur.2020.582402/full |
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