Therapeutic Potential of αS Evolvability for NeuropathicGaucher Disease

Therapeutic Potential of αS Evolvability for NeuropathicGaucher Disease

Gaucher disease (GD), the most common lysosomal storage disorder (LSD), is caused by autosomal recessive mutations of the glucocerebrosidase gene, <i>GBA1</i>. In the majority of cases, GD has a non-neuropathic chronic form with adult onset (GD1), while other cases are more acute and sev...

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Bibliographic Details
Main Authors: Jianshe Wei, Yoshiki Takamatsu, Ryoko Wada, Masayo Fujita, Gilbert Ho, Eliezer Masliah, Makoto Hashimoto
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:Biomolecules
Subjects:
Gaucher disease (GD), Parkinson’s disease (PD), autosomal recessive
α-synuclein (αS), evolvability
antagonistic pleiotropy
β-synuclein (βS)
Online Access:https://www.mdpi.com/2218-273X/11/2/289

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