The von Willebrand Factor Collagen-Binding Activity, the Concentrations of Tissue-type Plasminogen Activator and Its Inhibitor in Patients with Mechanical Injury

• Main Authors: P. V. Gromov, K. G. Shapovalov, Yu. A. Vitkovsky
• Format: Article
• Language: Russian
• Published: Russian Academy of Medical Sciences 2009-08-01
• Series: Obŝaâ Reanimatologiâ
• Online Access: https://www.reanimatology.com/rmt/article/view/548

Objective: to evaluate the von Willebrand factor (vWF) collagen-binding activity and to measure the concentration of tissue-type plasminogen activator (t-PA) and its inhibitor (PAI-1) in the plasma of patients with traumatic shock. Subjects and methods. Forty-four patients were examined. The vWF collagen-binding activity and the concentrations of t-PA and PAI-1 in the plasma were measured by enzyme immunoassay. Results. The plasma taken from patients with second-degree traumatic shock showed a 2.5-fold increase in vWF collagen-binding activity, as compared with the controls. With severer injury, the collagen-binding activity of vWF increased by 2.9 times in a group of patients with third-degree shock. It was established that in patients with second-degree traumatic shock, the euglobulin fibrinolysis (EF) time was more 1.6 times longer, the plasma concentrations of t-PA and PAI-1 being decreased by 2 and 1.7 times, respectively. Moreover, in patients with third-degree traumatic shock, EF was 2.1 longer and the levels of t-PA and PAI-1 were 3 and 1.8 times lower. Conclusion. The plasma collagen-binding activity of vWF was increased by 2.5—2.9 times in patients with traumatic shock. The victims with traumatic shock showed 2—3- and 1.8—2-fold reductions in the level of t-PA and its inhibitor, respectively. Key words: shock, hemostasis, fibrinolysis.