A comparative study of the anti-inflammatory effect of aqueous extract of neem leaf and dexamethasone
The anti-inflammatory effect of aqueous extract of neem leaf (400 mg/kg body weight) was compared with that of dexamethasone (0.75 mg, intraperitoneally) by administering one hour before the formalin injection and once daily for 7 days in rats. The percentage of inhibition of paw edema in case of ne...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Bangladesh Pharmacological Society
2008-06-01
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| Series: | Bangladesh Journal of Pharmacology |
| Subjects: | |
| Online Access: | http://www.bdjpharmacol.com/0301/44.pdf |
| Summary: | The anti-inflammatory effect of aqueous extract of neem leaf (400 mg/kg body weight) was compared with that of dexamethasone (0.75 mg, intraperitoneally) by administering one hour before the formalin injection and once daily for 7 days in rats. The percentage of inhibition of paw edema in case of neem after 3 hours, 6 hours, on day 3, on day 7 after formalin injection were 28%, 40%, 45%, 58% respectively and that in case of dexamethasone after 3 hours, 6 hours, on day 3, on day 7 after formalin injection were 43%, 58%, 61%, 65% respectively. The reduction was statistically significant in each case (p<0.001). The present study suggests that anti-inflammatory effect of neem extract is less than that produced by dexamethasone. |
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| ISSN: | 1991-007X 1991-0088 |