Abnormal Vision-Based Displacement Perception in Parkinson’s Disease
In this work, we investigate the effect of Parkinson’s disease (PD), and common corresponding therapies on vision-based perception of motion, a critical perceptual ability required for performing a wide range of activities of daily livings. While PD has been recognized as mainly a motor disorder, se...
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doaj-a15f70cbd2e0457ea963dac55b603df72021-07-29T17:53:34ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2021-07-011510.3389/fnins.2021.676469676469Abnormal Vision-Based Displacement Perception in Parkinson’s DiseaseMatthew Bernardinis0Matthew Bernardinis1Matthew Bernardinis2S. Farokh Atashzar3Rajni V. Patel4Rajni V. Patel5Rajni V. Patel6Mandar S. Jog7Mandar S. Jog8Mandar S. Jog9School of Biomedical Engineering, Western University, London, ON, CanadaCanadian Surgical Technologies and Advanced Robotics, London Health Sciences Centre (LHSC), London, ON, CanadaLondon Movement Disorders Centre, LHSC, London, ON, CanadaElectrical and Computer Engineering, Mechanical and Aerospace Engineering, New York University (NYU), New York, NY, United StatesSchool of Biomedical Engineering, Western University, London, ON, CanadaCanadian Surgical Technologies and Advanced Robotics, London Health Sciences Centre (LHSC), London, ON, CanadaDepartment of Clinical Neurological Sciences and Electrical and Computer Engineering, Western University, London, ON, CanadaSchool of Biomedical Engineering, Western University, London, ON, CanadaLondon Movement Disorders Centre, LHSC, London, ON, CanadaDepartment of Clinical Neurological Sciences and Electrical and Computer Engineering, Western University, London, ON, CanadaIn this work, we investigate the effect of Parkinson’s disease (PD), and common corresponding therapies on vision-based perception of motion, a critical perceptual ability required for performing a wide range of activities of daily livings. While PD has been recognized as mainly a motor disorder, sensory manifestation of PD can also play a major role in the resulting disability. In this paper, for the first time, the effect of disease duration and common therapies on vision-based perception of displacement were investigated. The study is conducted in a movement-independent manner, to reject the shadowing effects and isolate the targeted perceptual disorder to the maximum possible extent. Data was collected using a computerized graphical tool on 37 PD patients [6 early-stage de novo, 25 mid-stage using levodopa therapy, six later-stage using deep brain stimulation (DBS)] and 15 control participants. Besides the absolute measurement of perception through a psychometric analysis on two tested position reference magnitudes, we also investigated the linearity in perception using Weber’s fraction. The results showed that individuals with PD displayed significant perceptual impairments compared to controls, though early-stage patients were not impaired. Mid-stage patients displayed impairments at the greater of the two tested reference magnitudes, while late-stage patients were impaired at both reference magnitudes. Levodopa and DBS use did not cause statistically significant differences in absolute displacement perception. The findings suggest abnormal visual processing in PD increasing with disease development, perhaps contributing to sensory-based impairments of PD such as bradykinesia, visuospatial deficits, and abnormal object recognition.https://www.frontiersin.org/articles/10.3389/fnins.2021.676469/fullParkinson’s diseaseperceptionvisiondisplacementlevodopadeep brain stimulation |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Matthew Bernardinis Matthew Bernardinis Matthew Bernardinis S. Farokh Atashzar Rajni V. Patel Rajni V. Patel Rajni V. Patel Mandar S. Jog Mandar S. Jog Mandar S. Jog |
spellingShingle |
Matthew Bernardinis Matthew Bernardinis Matthew Bernardinis S. Farokh Atashzar Rajni V. Patel Rajni V. Patel Rajni V. Patel Mandar S. Jog Mandar S. Jog Mandar S. Jog Abnormal Vision-Based Displacement Perception in Parkinson’s Disease Frontiers in Neuroscience Parkinson’s disease perception vision displacement levodopa deep brain stimulation |
author_facet |
Matthew Bernardinis Matthew Bernardinis Matthew Bernardinis S. Farokh Atashzar Rajni V. Patel Rajni V. Patel Rajni V. Patel Mandar S. Jog Mandar S. Jog Mandar S. Jog |
author_sort |
Matthew Bernardinis |
title |
Abnormal Vision-Based Displacement Perception in Parkinson’s Disease |
title_short |
Abnormal Vision-Based Displacement Perception in Parkinson’s Disease |
title_full |
Abnormal Vision-Based Displacement Perception in Parkinson’s Disease |
title_fullStr |
Abnormal Vision-Based Displacement Perception in Parkinson’s Disease |
title_full_unstemmed |
Abnormal Vision-Based Displacement Perception in Parkinson’s Disease |
title_sort |
abnormal vision-based displacement perception in parkinson’s disease |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Neuroscience |
issn |
1662-453X |
publishDate |
2021-07-01 |
description |
In this work, we investigate the effect of Parkinson’s disease (PD), and common corresponding therapies on vision-based perception of motion, a critical perceptual ability required for performing a wide range of activities of daily livings. While PD has been recognized as mainly a motor disorder, sensory manifestation of PD can also play a major role in the resulting disability. In this paper, for the first time, the effect of disease duration and common therapies on vision-based perception of displacement were investigated. The study is conducted in a movement-independent manner, to reject the shadowing effects and isolate the targeted perceptual disorder to the maximum possible extent. Data was collected using a computerized graphical tool on 37 PD patients [6 early-stage de novo, 25 mid-stage using levodopa therapy, six later-stage using deep brain stimulation (DBS)] and 15 control participants. Besides the absolute measurement of perception through a psychometric analysis on two tested position reference magnitudes, we also investigated the linearity in perception using Weber’s fraction. The results showed that individuals with PD displayed significant perceptual impairments compared to controls, though early-stage patients were not impaired. Mid-stage patients displayed impairments at the greater of the two tested reference magnitudes, while late-stage patients were impaired at both reference magnitudes. Levodopa and DBS use did not cause statistically significant differences in absolute displacement perception. The findings suggest abnormal visual processing in PD increasing with disease development, perhaps contributing to sensory-based impairments of PD such as bradykinesia, visuospatial deficits, and abnormal object recognition. |
topic |
Parkinson’s disease perception vision displacement levodopa deep brain stimulation |
url |
https://www.frontiersin.org/articles/10.3389/fnins.2021.676469/full |
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