Receptor Heterodimerization and Co-Receptor Engagement in TLR2 Activation Induced by MIC1 and MIC4 from <em>Toxoplasma gondii</em>

Receptor Heterodimerization and Co-Receptor Engagement in TLR2 Activation Induced by MIC1 and MIC4 from <em>Toxoplasma gondii</em>

The microneme organelles of <i>Toxoplasma gondii</i> tachyzoites release protein complexes (MICs), including one composed of the transmembrane protein MIC6 plus MIC1 and MIC4. In this complex, carbohydrate recognition domains of MIC1 and MIC4 are exposed and interact with terminal sialic...

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Bibliographic Details
Main Authors: Flávia Costa Mendonça-Natividade, Carla Duque Lopes, Rafael Ricci-Azevedo, Aline Sardinha-Silva, Camila Figueiredo Pinzan, Ana Claudia Paiva Alegre-Maller, Lilian L. Nohara, Alan B. Carneiro, Ademilson Panunto-Castelo, Igor C. Almeida, Maria Cristina Roque-Barreira
Format: Article
Language:English
Published: MDPI AG 2019-10-01
Series:International Journal of Molecular Sciences
Subjects:
<i>toxoplasma gondii</i>
microneme proteins
toll-like receptor 2
tlr co-receptors
tlr heterodimerization
cd14
cd36
Online Access:https://www.mdpi.com/1422-0067/20/20/5001

Internet

https://www.mdpi.com/1422-0067/20/20/5001

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