Nintedanib in the treatment of idiopathic pulmonary fibrosis
Idiopathic pulmonary fibrosis (IPF) is a progressive and ultimately fatal lung disease that occurs in older adults. The clinical course of IPF is variable and hard to predict in an individual patient. Nintedanib is a tyrosine kinase inhibitor that has recently been approved in the US and European Un...
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doaj-a1615910661048158eface8191de2af12020-11-25T02:52:21ZengSAGE PublishingTherapeutic Advances in Respiratory Disease1753-46581753-46662015-06-01910.1177/1753465815579365Nintedanib in the treatment of idiopathic pulmonary fibrosisMariano E. MazzeiLuca RicheldiHarold R. CollardIdiopathic pulmonary fibrosis (IPF) is a progressive and ultimately fatal lung disease that occurs in older adults. The clinical course of IPF is variable and hard to predict in an individual patient. Nintedanib is a tyrosine kinase inhibitor that has recently been approved in the US and European Union for the treatment of IPF. Preclinical studies have shown that nintedanib interferes with processes active in fibrosis such as fibroblast proliferation, migration and differentiation and the secretion of extracellular matrix. The safety and efficacy of nintedanib have been investigated in the phase II TOMORROW trial and in two replicate 52-week randomized, placebo-controlled phase III trials known as the INPULSIS trials. These trials demonstrated that nintedanib slowed disease progression by reducing the annual rate of decline in forced vital capacity, with a manageable side-effect profile. In this review, we summarize key data supporting nintedanib as a treatment for patients with IPF and address key questions regarding the use of nintedanib in the clinical setting.https://doi.org/10.1177/1753465815579365 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Mariano E. Mazzei Luca Richeldi Harold R. Collard |
spellingShingle |
Mariano E. Mazzei Luca Richeldi Harold R. Collard Nintedanib in the treatment of idiopathic pulmonary fibrosis Therapeutic Advances in Respiratory Disease |
author_facet |
Mariano E. Mazzei Luca Richeldi Harold R. Collard |
author_sort |
Mariano E. Mazzei |
title |
Nintedanib in the treatment of idiopathic pulmonary fibrosis |
title_short |
Nintedanib in the treatment of idiopathic pulmonary fibrosis |
title_full |
Nintedanib in the treatment of idiopathic pulmonary fibrosis |
title_fullStr |
Nintedanib in the treatment of idiopathic pulmonary fibrosis |
title_full_unstemmed |
Nintedanib in the treatment of idiopathic pulmonary fibrosis |
title_sort |
nintedanib in the treatment of idiopathic pulmonary fibrosis |
publisher |
SAGE Publishing |
series |
Therapeutic Advances in Respiratory Disease |
issn |
1753-4658 1753-4666 |
publishDate |
2015-06-01 |
description |
Idiopathic pulmonary fibrosis (IPF) is a progressive and ultimately fatal lung disease that occurs in older adults. The clinical course of IPF is variable and hard to predict in an individual patient. Nintedanib is a tyrosine kinase inhibitor that has recently been approved in the US and European Union for the treatment of IPF. Preclinical studies have shown that nintedanib interferes with processes active in fibrosis such as fibroblast proliferation, migration and differentiation and the secretion of extracellular matrix. The safety and efficacy of nintedanib have been investigated in the phase II TOMORROW trial and in two replicate 52-week randomized, placebo-controlled phase III trials known as the INPULSIS trials. These trials demonstrated that nintedanib slowed disease progression by reducing the annual rate of decline in forced vital capacity, with a manageable side-effect profile. In this review, we summarize key data supporting nintedanib as a treatment for patients with IPF and address key questions regarding the use of nintedanib in the clinical setting. |
url |
https://doi.org/10.1177/1753465815579365 |
work_keys_str_mv |
AT marianoemazzei nintedanibinthetreatmentofidiopathicpulmonaryfibrosis AT lucaricheldi nintedanibinthetreatmentofidiopathicpulmonaryfibrosis AT haroldrcollard nintedanibinthetreatmentofidiopathicpulmonaryfibrosis |
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