Characterization of Sodium Alginate Hydrogels Reinforced with Nanoparticles of Hydroxyapatite for Biomedical Applications
In recent years, researchers working in biomedical science and technology have investigated alternatives for enhancing the mechanical properties of biomedical materials. In this work, sodium alginate (SA) hydrogel-reinforced nanoparticles (NPs) of hydroxyapatite (HA) were prepared to enhance the mec...
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doaj-a165603cfa894913b5dcc19f883cf5772021-09-09T13:54:23ZengMDPI AGPolymers2073-43602021-08-01132927292710.3390/polym13172927Characterization of Sodium Alginate Hydrogels Reinforced with Nanoparticles of Hydroxyapatite for Biomedical ApplicationsJosé Antonio Sánchez-Fernández0Gerardo Presbítero-Espinosa1Laura Peña-Parás2Edgar Iván Rodríguez Pizaña3Katya Patricia Villarreal Galván4Michal Vopálenský5Ivana Kumpová6Luis Ernesto Elizalde-Herrera7Procesos de Polimerización, Centro de Investigación en Química Aplicada, Blvd. Enrique Reyna No. 140, Saltillo 25294, MexicoCentro de Ingeniería y Desarrollo Industrial (CIDESI), Sede Nuevo León 66629, MexicoEngineering Department, Universidad de Monterrey, Av. Morones Prieto 4500 Pte., San Pedro Garza García 66238, MexicoBiomedical Engineering Program, Universidad de Monterrey, Av. Morones Prieto 4500 Pte., San Pedro Garza García 66238, MexicoBiomedical Engineering Program, Universidad de Monterrey, Av. Morones Prieto 4500 Pte., San Pedro Garza García 66238, MexicoCzech Academy of Sciences, Institute of Theoretical and Applied Mechanics, Prosecká 76, 190 00 Prague, Czech RepublicCzech Academy of Sciences, Institute of Theoretical and Applied Mechanics, Prosecká 76, 190 00 Prague, Czech RepublicSíntesis de Polímeros, Centro de Investigación en Química Aplicada, Blvd. Ing. Enrique Reyna No. 140, Saltillo 25294, MexicoIn recent years, researchers working in biomedical science and technology have investigated alternatives for enhancing the mechanical properties of biomedical materials. In this work, sodium alginate (SA) hydrogel-reinforced nanoparticles (NPs) of hydroxyapatite (HA) were prepared to enhance the mechanical properties of this polymer. Compression tests showed an increase of 354.54% in ultimate compressive strength (UCS), and 154.36% in Young’s modulus with the addition of these NPs compared with pure SA. Thermogravimetric analysis (TGA) revealed that the amount of residual water is not negligible and covered a range from 20 to 35 wt%, and the decomposition degree of the alginate depends on the hydroxyapatite content, possibly due to the displacement of sodium ions by the hydroxyapatite and not by calcium chloride. Further, there is an important effect possibly due to the existence of an interaction of hydrogen bonds between the hydroxyl of the alginate and the oxygen atoms of the hydroxyapatite, so signals appear upfield in nuclear magnetic resonance (NMR) data. An increase in the accumulation of HA particles was observed with the use of X-ray microtomography, in which the quantified volume of particles per reconstructed volume corresponded accordingly to the increase in the mechanical properties of the hydrogel.https://www.mdpi.com/2073-4360/13/17/2927hydrogelshydroxyapatite nanoparticlesmechanical propertiesintermolecular interactionsmicro-ct |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
José Antonio Sánchez-Fernández Gerardo Presbítero-Espinosa Laura Peña-Parás Edgar Iván Rodríguez Pizaña Katya Patricia Villarreal Galván Michal Vopálenský Ivana Kumpová Luis Ernesto Elizalde-Herrera |
spellingShingle |
José Antonio Sánchez-Fernández Gerardo Presbítero-Espinosa Laura Peña-Parás Edgar Iván Rodríguez Pizaña Katya Patricia Villarreal Galván Michal Vopálenský Ivana Kumpová Luis Ernesto Elizalde-Herrera Characterization of Sodium Alginate Hydrogels Reinforced with Nanoparticles of Hydroxyapatite for Biomedical Applications Polymers hydrogels hydroxyapatite nanoparticles mechanical properties intermolecular interactions micro-ct |
author_facet |
José Antonio Sánchez-Fernández Gerardo Presbítero-Espinosa Laura Peña-Parás Edgar Iván Rodríguez Pizaña Katya Patricia Villarreal Galván Michal Vopálenský Ivana Kumpová Luis Ernesto Elizalde-Herrera |
author_sort |
José Antonio Sánchez-Fernández |
title |
Characterization of Sodium Alginate Hydrogels Reinforced with Nanoparticles of Hydroxyapatite for Biomedical Applications |
title_short |
Characterization of Sodium Alginate Hydrogels Reinforced with Nanoparticles of Hydroxyapatite for Biomedical Applications |
title_full |
Characterization of Sodium Alginate Hydrogels Reinforced with Nanoparticles of Hydroxyapatite for Biomedical Applications |
title_fullStr |
Characterization of Sodium Alginate Hydrogels Reinforced with Nanoparticles of Hydroxyapatite for Biomedical Applications |
title_full_unstemmed |
Characterization of Sodium Alginate Hydrogels Reinforced with Nanoparticles of Hydroxyapatite for Biomedical Applications |
title_sort |
characterization of sodium alginate hydrogels reinforced with nanoparticles of hydroxyapatite for biomedical applications |
publisher |
MDPI AG |
series |
Polymers |
issn |
2073-4360 |
publishDate |
2021-08-01 |
description |
In recent years, researchers working in biomedical science and technology have investigated alternatives for enhancing the mechanical properties of biomedical materials. In this work, sodium alginate (SA) hydrogel-reinforced nanoparticles (NPs) of hydroxyapatite (HA) were prepared to enhance the mechanical properties of this polymer. Compression tests showed an increase of 354.54% in ultimate compressive strength (UCS), and 154.36% in Young’s modulus with the addition of these NPs compared with pure SA. Thermogravimetric analysis (TGA) revealed that the amount of residual water is not negligible and covered a range from 20 to 35 wt%, and the decomposition degree of the alginate depends on the hydroxyapatite content, possibly due to the displacement of sodium ions by the hydroxyapatite and not by calcium chloride. Further, there is an important effect possibly due to the existence of an interaction of hydrogen bonds between the hydroxyl of the alginate and the oxygen atoms of the hydroxyapatite, so signals appear upfield in nuclear magnetic resonance (NMR) data. An increase in the accumulation of HA particles was observed with the use of X-ray microtomography, in which the quantified volume of particles per reconstructed volume corresponded accordingly to the increase in the mechanical properties of the hydrogel. |
topic |
hydrogels hydroxyapatite nanoparticles mechanical properties intermolecular interactions micro-ct |
url |
https://www.mdpi.com/2073-4360/13/17/2927 |
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