The Dynamic Interface Between the Bone Marrow Vascular Niche and Hematopoietic Stem Cells in Myeloid Malignancy

The Dynamic Interface Between the Bone Marrow Vascular Niche and Hematopoietic Stem Cells in Myeloid Malignancy

Hematopoietic stem cells interact with bone marrow niches, including highly specialized blood vessels. Recent studies have revealed the phenotypic and functional heterogeneity of bone marrow endothelial cells. This has facilitated the analysis of the vascular microenvironment in steady state and mal...

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Main Authors: Laura Mosteo, Joanna Storer, Kiran Batta, Emma J. Searle, Delfim Duarte, Daniel H. Wiseman
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
vascular niche
hematopoietic stem cells
acute myeloid leukemia
myelodysplastic syndromes
targeted therapies
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.635189/full
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spelling doaj-a17adb3b88eb49d38a801e90a5148d332021-03-11T05:26:44ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2021-03-01910.3389/fcell.2021.635189635189The Dynamic Interface Between the Bone Marrow Vascular Niche and Hematopoietic Stem Cells in Myeloid MalignancyLaura Mosteo0Joanna Storer1Kiran Batta2Emma J. Searle3Emma J. Searle4Delfim Duarte5Delfim Duarte6Delfim Duarte7Daniel H. Wiseman8Daniel H. Wiseman9Instituto de Investigação e Inovação em Saúde (i3S), University of Porto, Porto, PortugalEpigenetics of Haematopoiesis Group, Division of Cancer Sciences, The University of Manchester, Manchester, United KingdomEpigenetics of Haematopoiesis Group, Division of Cancer Sciences, The University of Manchester, Manchester, United KingdomEpigenetics of Haematopoiesis Group, Division of Cancer Sciences, The University of Manchester, Manchester, United KingdomDepartment of Haematology, The Christie NHS Foundation Trust, Manchester, United KingdomInstituto de Investigação e Inovação em Saúde (i3S), University of Porto, Porto, PortugalDepartment of Biomedicine, Faculdade de Medicina da Universidade do Porto (FMUP), Porto, PortugalDepartment of Onco-Hematology, Instituto Português de Oncologia (IPO)-Porto, Porto, PortugalEpigenetics of Haematopoiesis Group, Division of Cancer Sciences, The University of Manchester, Manchester, United KingdomDepartment of Haematology, The Christie NHS Foundation Trust, Manchester, United KingdomHematopoietic stem cells interact with bone marrow niches, including highly specialized blood vessels. Recent studies have revealed the phenotypic and functional heterogeneity of bone marrow endothelial cells. This has facilitated the analysis of the vascular microenvironment in steady state and malignant hematopoiesis. In this review, we provide an overview of the bone marrow microenvironment, focusing on refined analyses of the marrow vascular compartment performed in mouse studies. We also discuss the emerging role of the vascular niche in “inflamm-aging” and clonal hematopoiesis, and how the endothelial microenvironment influences, supports and interacts with hematopoietic cells in acute myeloid leukemia and myelodysplastic syndromes, as exemplar states of malignant myelopoiesis. Finally, we provide an overview of strategies for modulating these bidirectional interactions to therapeutic effect in myeloid malignancies.https://www.frontiersin.org/articles/10.3389/fcell.2021.635189/fullvascular nichehematopoietic stem cellsacute myeloid leukemiamyelodysplastic syndromestargeted therapies
collection DOAJ
language English
format Article
sources DOAJ
author Laura Mosteo
Joanna Storer
Kiran Batta
Emma J. Searle
Emma J. Searle
Delfim Duarte
Delfim Duarte
Delfim Duarte
Daniel H. Wiseman
Daniel H. Wiseman
spellingShingle Laura Mosteo
Joanna Storer
Kiran Batta
Emma J. Searle
Emma J. Searle
Delfim Duarte
Delfim Duarte
Delfim Duarte
Daniel H. Wiseman
Daniel H. Wiseman
The Dynamic Interface Between the Bone Marrow Vascular Niche and Hematopoietic Stem Cells in Myeloid Malignancy
Frontiers in Cell and Developmental Biology
vascular niche
hematopoietic stem cells
acute myeloid leukemia
myelodysplastic syndromes
targeted therapies
author_facet Laura Mosteo
Joanna Storer
Kiran Batta
Emma J. Searle
Emma J. Searle
Delfim Duarte
Delfim Duarte
Delfim Duarte
Daniel H. Wiseman
Daniel H. Wiseman
author_sort Laura Mosteo
title The Dynamic Interface Between the Bone Marrow Vascular Niche and Hematopoietic Stem Cells in Myeloid Malignancy
title_short The Dynamic Interface Between the Bone Marrow Vascular Niche and Hematopoietic Stem Cells in Myeloid Malignancy
title_full The Dynamic Interface Between the Bone Marrow Vascular Niche and Hematopoietic Stem Cells in Myeloid Malignancy
title_fullStr The Dynamic Interface Between the Bone Marrow Vascular Niche and Hematopoietic Stem Cells in Myeloid Malignancy
title_full_unstemmed The Dynamic Interface Between the Bone Marrow Vascular Niche and Hematopoietic Stem Cells in Myeloid Malignancy
title_sort dynamic interface between the bone marrow vascular niche and hematopoietic stem cells in myeloid malignancy
publisher Frontiers Media S.A.
series Frontiers in Cell and Developmental Biology
issn 2296-634X
publishDate 2021-03-01
description Hematopoietic stem cells interact with bone marrow niches, including highly specialized blood vessels. Recent studies have revealed the phenotypic and functional heterogeneity of bone marrow endothelial cells. This has facilitated the analysis of the vascular microenvironment in steady state and malignant hematopoiesis. In this review, we provide an overview of the bone marrow microenvironment, focusing on refined analyses of the marrow vascular compartment performed in mouse studies. We also discuss the emerging role of the vascular niche in “inflamm-aging” and clonal hematopoiesis, and how the endothelial microenvironment influences, supports and interacts with hematopoietic cells in acute myeloid leukemia and myelodysplastic syndromes, as exemplar states of malignant myelopoiesis. Finally, we provide an overview of strategies for modulating these bidirectional interactions to therapeutic effect in myeloid malignancies.
topic vascular niche
hematopoietic stem cells
acute myeloid leukemia
myelodysplastic syndromes
targeted therapies
url https://www.frontiersin.org/articles/10.3389/fcell.2021.635189/full
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