In vitro evaluation of anticancer activity of sodium hyaluronate-titanium dioxide bionanocomposite
The purpose of the current research is to optimize the synthesis of sodium hyaluronatetitanium dioxide nanocomposite with the highest anticancer activity. To this end, the Taguchi method was followed to design nine experiments with different ratios of sodium hyaluronate biopolymer, titanium dioxide...
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doaj-a188d60c75aa4a1fb8fd77c4230e89d32021-09-06T19:22:04ZengSciendoCurrent Issues in Pharmacy and Medical Sciences2084-980X2300-66762019-06-013229910310.2478/cipms-2019-0019cipms-2019-0019In vitro evaluation of anticancer activity of sodium hyaluronate-titanium dioxide bionanocompositeSafaei Mohsen0Taran Mojtaba1Imani Mohammad Moslem2Moradpoor Hedaiat3Golshah Amin4Upadhyay Prabhat5Advanced Dental Sciences Research Laboratory, School of Dentistry, Kermanshah University of Medical Sciences, Kermanshah, IranDepartment of Nanobiotechnology, Faculty of Science, Razi University, Kermanshah, IranDepartment of Orthodontics, School of Dentistry, Kermanshah University of Medical Sciences, Kermanshah, IranDepartment of Prosthodontics, School of Dentistry, Kermanshah University of Medical Sciences, Kermanshah, IranDepartment of Orthodontics, School of Dentistry, Kermanshah University of Medical Sciences, Kermanshah, IranDepartment of Pharmacology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, IndiaThe purpose of the current research is to optimize the synthesis of sodium hyaluronatetitanium dioxide nanocomposite with the highest anticancer activity. To this end, the Taguchi method was followed to design nine experiments with different ratios of sodium hyaluronate biopolymer, titanium dioxide nanoparticles and stirring times. The results of scanning electron microscopy (SEM) confirmed the synthesis of the nanoparticle and nanocomposite. The comparison of anticancer activity level of synthesized nanocomposites using MTT assay showed that the nanocomposite synthesized in the conditions of experiment 9 (8 mg/ml of titanium dioxide nanoparticles, 2 mg/ml of sodium hyaluronate biopolymer and 60 min stirring time) had the maximum anticancer activity against Michigan Cancer Foundation-7 (MCF-7) cell line. According to the results, the Taguchi method can be employed as an effective and useful strategy to save time and cost in order to determine the optimal conditions for the synthesis of sodium hyaluronate-titanium dioxide nanocomposite with the most favorable anticancer activity.https://doi.org/10.2478/cipms-2019-0019anticancernanocompositetaguchi methodtio2 nanoparticlessodium hyaluronatebiopolymer |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Safaei Mohsen Taran Mojtaba Imani Mohammad Moslem Moradpoor Hedaiat Golshah Amin Upadhyay Prabhat |
spellingShingle |
Safaei Mohsen Taran Mojtaba Imani Mohammad Moslem Moradpoor Hedaiat Golshah Amin Upadhyay Prabhat In vitro evaluation of anticancer activity of sodium hyaluronate-titanium dioxide bionanocomposite Current Issues in Pharmacy and Medical Sciences anticancer nanocomposite taguchi method tio2 nanoparticles sodium hyaluronate biopolymer |
author_facet |
Safaei Mohsen Taran Mojtaba Imani Mohammad Moslem Moradpoor Hedaiat Golshah Amin Upadhyay Prabhat |
author_sort |
Safaei Mohsen |
title |
In vitro evaluation of anticancer activity of sodium hyaluronate-titanium dioxide bionanocomposite |
title_short |
In vitro evaluation of anticancer activity of sodium hyaluronate-titanium dioxide bionanocomposite |
title_full |
In vitro evaluation of anticancer activity of sodium hyaluronate-titanium dioxide bionanocomposite |
title_fullStr |
In vitro evaluation of anticancer activity of sodium hyaluronate-titanium dioxide bionanocomposite |
title_full_unstemmed |
In vitro evaluation of anticancer activity of sodium hyaluronate-titanium dioxide bionanocomposite |
title_sort |
in vitro evaluation of anticancer activity of sodium hyaluronate-titanium dioxide bionanocomposite |
publisher |
Sciendo |
series |
Current Issues in Pharmacy and Medical Sciences |
issn |
2084-980X 2300-6676 |
publishDate |
2019-06-01 |
description |
The purpose of the current research is to optimize the synthesis of sodium hyaluronatetitanium dioxide nanocomposite with the highest anticancer activity. To this end, the Taguchi method was followed to design nine experiments with different ratios of sodium hyaluronate biopolymer, titanium dioxide nanoparticles and stirring times. The results of scanning electron microscopy (SEM) confirmed the synthesis of the nanoparticle and nanocomposite. The comparison of anticancer activity level of synthesized nanocomposites using MTT assay showed that the nanocomposite synthesized in the conditions of experiment 9 (8 mg/ml of titanium dioxide nanoparticles, 2 mg/ml of sodium hyaluronate biopolymer and 60 min stirring time) had the maximum anticancer activity against Michigan Cancer Foundation-7 (MCF-7) cell line. According to the results, the Taguchi method can be employed as an effective and useful strategy to save time and cost in order to determine the optimal conditions for the synthesis of sodium hyaluronate-titanium dioxide nanocomposite with the most favorable anticancer activity. |
topic |
anticancer nanocomposite taguchi method tio2 nanoparticles sodium hyaluronate biopolymer |
url |
https://doi.org/10.2478/cipms-2019-0019 |
work_keys_str_mv |
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