Sympathetic nervous system controls resolution of inflammation via regulation of repulsive guidance molecule A

Diverse interactions between the nervous and immune systems have been shown, but specific mechanistic insights are still lacking. Here the authors show, using both mouse inflammation models and clinical correlation, that adrenergic nerve may ameliorate inflammation by inducing repulsive guidance mol...

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Bibliographic Details
Main Authors: Andreas Körner, Martin Schlegel, Torsten Kaussen, Verena Gudernatsch, Georg Hansmann, Timo Schumacher, Martin Giera, Valbona Mirakaj
Format: Article
Language:English
Published: Nature Publishing Group 2019-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-08328-5
Description
Summary:Diverse interactions between the nervous and immune systems have been shown, but specific mechanistic insights are still lacking. Here the authors show, using both mouse inflammation models and clinical correlation, that adrenergic nerve may ameliorate inflammation by inducing repulsive guidance molecule A signalling.
ISSN:2041-1723