Sympathetic nervous system controls resolution of inflammation via regulation of repulsive guidance molecule A

Diverse interactions between the nervous and immune systems have been shown, but specific mechanistic insights are still lacking. Here the authors show, using both mouse inflammation models and clinical correlation, that adrenergic nerve may ameliorate inflammation by inducing repulsive guidance mol...

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Main Authors:	Andreas Körner, Martin Schlegel, Torsten Kaussen, Verena Gudernatsch, Georg Hansmann, Timo Schumacher, Martin Giera, Valbona Mirakaj
Format:	Article
Language:	English
Published:	Nature Publishing Group 2019-02-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-019-08328-5

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spelling	doaj-a18f549d707447048a7e5939b8007a6a2021-05-11T11:47:56ZengNature Publishing GroupNature Communications2041-17232019-02-0110111510.1038/s41467-019-08328-5Sympathetic nervous system controls resolution of inflammation via regulation of repulsive guidance molecule AAndreas Körner0Martin Schlegel1Torsten Kaussen2Verena Gudernatsch3Georg Hansmann4Timo Schumacher5Martin Giera6Valbona Mirakaj7Department of Anesthesiology and Intensive Care Medicine, Molecular Intensive Care Medicine, University Hospital Tübingen, Eberhard-Karls UniversityDepartment of Anesthesiology and Intensive Care Medicine, Molecular Intensive Care Medicine, University Hospital Tübingen, Eberhard-Karls UniversityDepartment of Pediatric Cardiology and Critical CareDepartment of Anesthesiology and Intensive Care Medicine, Molecular Intensive Care Medicine, University Hospital Tübingen, Eberhard-Karls UniversityDepartment of Pediatric Cardiology and Critical CareDepartment of Pediatric Cardiology and Critical CareCenter for Proteomics and Metabolomics, Leiden University Medical Center (LUMC)Department of Anesthesiology and Intensive Care Medicine, Molecular Intensive Care Medicine, University Hospital Tübingen, Eberhard-Karls UniversityDiverse interactions between the nervous and immune systems have been shown, but specific mechanistic insights are still lacking. Here the authors show, using both mouse inflammation models and clinical correlation, that adrenergic nerve may ameliorate inflammation by inducing repulsive guidance molecule A signalling.https://doi.org/10.1038/s41467-019-08328-5
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Andreas Körner Martin Schlegel Torsten Kaussen Verena Gudernatsch Georg Hansmann Timo Schumacher Martin Giera Valbona Mirakaj
spellingShingle	Andreas Körner Martin Schlegel Torsten Kaussen Verena Gudernatsch Georg Hansmann Timo Schumacher Martin Giera Valbona Mirakaj Sympathetic nervous system controls resolution of inflammation via regulation of repulsive guidance molecule A Nature Communications
author_facet	Andreas Körner Martin Schlegel Torsten Kaussen Verena Gudernatsch Georg Hansmann Timo Schumacher Martin Giera Valbona Mirakaj
author_sort	Andreas Körner
title	Sympathetic nervous system controls resolution of inflammation via regulation of repulsive guidance molecule A
title_short	Sympathetic nervous system controls resolution of inflammation via regulation of repulsive guidance molecule A
title_full	Sympathetic nervous system controls resolution of inflammation via regulation of repulsive guidance molecule A
title_fullStr	Sympathetic nervous system controls resolution of inflammation via regulation of repulsive guidance molecule A
title_full_unstemmed	Sympathetic nervous system controls resolution of inflammation via regulation of repulsive guidance molecule A
title_sort	sympathetic nervous system controls resolution of inflammation via regulation of repulsive guidance molecule a
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2019-02-01
description	Diverse interactions between the nervous and immune systems have been shown, but specific mechanistic insights are still lacking. Here the authors show, using both mouse inflammation models and clinical correlation, that adrenergic nerve may ameliorate inflammation by inducing repulsive guidance molecule A signalling.
url	https://doi.org/10.1038/s41467-019-08328-5
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Sympathetic nervous system controls resolution of inflammation via regulation of repulsive guidance molecule A

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