Fluorescent properties and in vitro studies of new dehydroabietic acid-based diarylamines fluorescent probes
A series of dehydroabietic acid-based diarylamines have been synthesized in order to investigate their fluorescent properties, photostability, cell toxicity and in vitro fluorescence imaging. The geometries as well as their molecular properties were optimized at the B3LYP/6-31G* level using Gaussian...
Main Author: | |
---|---|
Format: | Article |
Language: | English |
Published: |
Higher Education Press
2017-03-01
|
Series: | Frontiers of Agricultural Science and Engineering |
Subjects: | |
Online Access: | http://academic.hep.com.cn/fase/fileup/2095-7505/PDF/1484894005956-333348656.pdf |
id |
doaj-a19cfda6c423437b955867e3a6b693a5 |
---|---|
record_format |
Article |
spelling |
doaj-a19cfda6c423437b955867e3a6b693a52020-11-24T22:31:24ZengHigher Education PressFrontiers of Agricultural Science and Engineering2095-75052017-03-014110611510.15302/J-FASE-2017133Fluorescent properties and in vitro studies of new dehydroabietic acid-based diarylamines fluorescent probesHong GAO,Jie SONG,Shibin SHANG,Zhanqian SONG01. Institute of Chemical Industry of Forest Products, Chinese Academy of Forestry; National Engineering Laboratory of Biomass Chemical Utilization/Key Laboratory of Biomass Energy and Material, Jiangsu Province, Nanjing 210042, China; 2. Department of Chemistry and Biochemistry, University of Michigan-Flint, Flint, MI 48502, USAA series of dehydroabietic acid-based diarylamines have been synthesized in order to investigate their fluorescent properties, photostability, cell toxicity and in vitro fluorescence imaging. The geometries as well as their molecular properties were optimized at the B3LYP/6-31G* level using Gaussian 03. The results indicate that molecular geometry, HOMO and LUMO energies, and energy gaps are important to predict absorption and fluorescent properties. Five of the compounds can be effectively taken up by human cervical carcinoma, human hepatocellular carcinoma SMMC-7721, human gastric cancer SGC-7901 and human lung adenocarcinoma A549 cells and strong blue fluorescent signals are detected in these cells. These compounds are potential candidates for fluorescent probes in biological diagnosis.http://academic.hep.com.cn/fase/fileup/2095-7505/PDF/1484894005956-333348656.pdfdehydroabietic acid-based diarylamine|DFT study|fluorescent probe|in vitro imaging |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Hong GAO,Jie SONG,Shibin SHANG,Zhanqian SONG |
spellingShingle |
Hong GAO,Jie SONG,Shibin SHANG,Zhanqian SONG Fluorescent properties and in vitro studies of new dehydroabietic acid-based diarylamines fluorescent probes Frontiers of Agricultural Science and Engineering dehydroabietic acid-based diarylamine|DFT study|fluorescent probe|in vitro imaging |
author_facet |
Hong GAO,Jie SONG,Shibin SHANG,Zhanqian SONG |
author_sort |
Hong GAO,Jie SONG,Shibin SHANG,Zhanqian SONG |
title |
Fluorescent properties and in vitro studies of new dehydroabietic acid-based diarylamines fluorescent probes |
title_short |
Fluorescent properties and in vitro studies of new dehydroabietic acid-based diarylamines fluorescent probes |
title_full |
Fluorescent properties and in vitro studies of new dehydroabietic acid-based diarylamines fluorescent probes |
title_fullStr |
Fluorescent properties and in vitro studies of new dehydroabietic acid-based diarylamines fluorescent probes |
title_full_unstemmed |
Fluorescent properties and in vitro studies of new dehydroabietic acid-based diarylamines fluorescent probes |
title_sort |
fluorescent properties and in vitro studies of new dehydroabietic acid-based diarylamines fluorescent probes |
publisher |
Higher Education Press |
series |
Frontiers of Agricultural Science and Engineering |
issn |
2095-7505 |
publishDate |
2017-03-01 |
description |
A series of dehydroabietic acid-based diarylamines have been synthesized in order to investigate their fluorescent properties, photostability, cell toxicity and in vitro fluorescence imaging. The geometries as well as their molecular properties were optimized at the B3LYP/6-31G* level using Gaussian 03. The results indicate that molecular geometry, HOMO and LUMO energies, and energy gaps are important to predict absorption and fluorescent properties. Five of the compounds can be effectively taken up by human cervical carcinoma, human hepatocellular carcinoma SMMC-7721, human gastric cancer SGC-7901 and human lung adenocarcinoma A549 cells and strong blue fluorescent signals are detected in these cells. These compounds are potential candidates for fluorescent probes in biological diagnosis. |
topic |
dehydroabietic acid-based diarylamine|DFT study|fluorescent probe|in vitro imaging |
url |
http://academic.hep.com.cn/fase/fileup/2095-7505/PDF/1484894005956-333348656.pdf |
work_keys_str_mv |
AT honggaojiesongshibinshangzhanqiansong fluorescentpropertiesandinvitrostudiesofnewdehydroabieticacidbaseddiarylaminesfluorescentprobes |
_version_ |
1725737212705767424 |