Standardized bioactive fraction of Phaleria macrocarpa (Proliverenol) prevents ethanol-induced hepatotoxicity via down-regulation of NF-κB-TNFα-caspase-8 pathway

Standardized bioactive fraction of Phaleria macrocarpa (Proliverenol) prevents ethanol-induced hepatotoxicity via down-regulation of NF-κB-TNFα-caspase-8 pathway

Objective: To verify that Proliverenol has a potential ability in protecting cells from ethanol-induced hepatotoxicity. Methods: Activity of Proliverenol against ethanol-induced apoptosis was evaluated at mRNA and protein levels in HepG2 cell exposed to Proliverenol for 1 and 3 h. Results: Prolivere...

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Bibliographic Details
Main Authors: Guntur Berlian, Olivia Mayasari Tandrasasmita, Raymond Rubianto Tjandrawinata
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2016-08-01
Series:Asian Pacific Journal of Tropical Biomedicine
Subjects:
Phaleria macrocarpa
Hepatoprotector
Liver injury
Cirrhosis
HepG2
Online Access:http://www.sciencedirect.com/science/article/pii/S2221169115310388

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