Prions amplify through degradation of the VPS10P sorting receptor sortilin.
Prion diseases are a group of fatal neurodegenerative disorders caused by prions, which consist mainly of the abnormally folded isoform of prion protein, PrPSc. A pivotal pathogenic event in prion disease is progressive accumulation of prions, or PrPSc, in brains through constitutive conformational...
Main Authors: | Keiji Uchiyama, Mitsuru Tomita, Masashi Yano, Junji Chida, Hideyuki Hara, Nandita Rani Das, Anders Nykjaer, Suehiro Sakaguchi |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2017-06-01
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Series: | PLoS Pathogens |
Online Access: | http://europepmc.org/articles/PMC5509376?pdf=render |
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