Use of Contrast-Enhanced Ultrasound with Sonazoid for Evaluating the Radiotherapy Efficacy for Hepatocellular Carcinoma
Radiotherapy is one of the available curative therapies for hepatocellular carcinoma (HCC). We investigate the use of contrast-enhanced ultrasound using Sonazoid (SCEUS) in evaluating the efficacy of radiotherapy for HCC. We enrolled 59 patients with 59 HCCs in this retrospective study. Tumor size a...
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doaj-a1b6c5c062ea49fb8463e0b135b49dfe2021-03-10T00:05:10ZengMDPI AGDiagnostics2075-44182021-03-011148648610.3390/diagnostics11030486Use of Contrast-Enhanced Ultrasound with Sonazoid for Evaluating the Radiotherapy Efficacy for Hepatocellular CarcinomaAkihiro Funaoka0Kazushi Numata1Atsuya Takeda2Yusuke Saigusa3Yuichirou Tsurugai4Hiromi Nihonmatsu5Makoto Chuma6Hiroyuki Fukuda7Masahiro Okada8Masayuki Nakano9Shin Maeda10Gastroenterological Center, Yokohama City University Medical Center, Yokohama, Kanagawa 232-0024, JapanGastroenterological Center, Yokohama City University Medical Center, Yokohama, Kanagawa 232-0024, JapanRadiation Oncology Center, Ofuna Chuo Hospital, Kamakura, Kanagawa 247-0056, JapanDepartment of Biostatistics, Yokohama City University Graduate School of Medicine, Yokohama, Kanagawa 236-0004, JapanRadiation Oncology Center, Ofuna Chuo Hospital, Kamakura, Kanagawa 247-0056, JapanGastroenterological Center, Yokohama City University Medical Center, Yokohama, Kanagawa 232-0024, JapanGastroenterological Center, Yokohama City University Medical Center, Yokohama, Kanagawa 232-0024, JapanGastroenterological Center, Yokohama City University Medical Center, Yokohama, Kanagawa 232-0024, JapanDepartment of Radiology, Nihon University School of Medicine, Tokyo 173-8610, JapanTokyo Central Pathology Laboratory, Hachioji, Tokyo 192-0024, JapanDivision of Gastroenterology, Yokohama City University Graduate School of Medicine, Yokohama, Kanagawa 236-0004, JapanRadiotherapy is one of the available curative therapies for hepatocellular carcinoma (HCC). We investigate the use of contrast-enhanced ultrasound using Sonazoid (SCEUS) in evaluating the efficacy of radiotherapy for HCC. We enrolled 59 patients with 59 HCCs in this retrospective study. Tumor size and tumor vascularity were evaluated using SCEUS before and 1, 3, 7, 10, and 13 months after radiotherapy. The median follow-up period was 44.5 months (range: 16–82 months). Of the HCCs, 95% (56/59) had no local recurrence, while 5% (3/59) did. At 13 months after radiotherapy, in cases with no local recurrence, SCEUS showed a reduction in tumor vascularity in all cases, while tumor size reduction (>30% reduction, compared with pre-radiotherapy) was observed in 82.1% (46/56). In all three cases of local recurrence, vascularity and tumor size reduction were not observed during the follow-up period and residual HCCs were demonstrated pathologically. Compared with cases with local recurrence, tumor size reduction and reduction in tumor vascularity (<i>p</i> < 0.001) were significantly greater in cases with no local recurrence at 13 months after radiotherapy. SCEUS may be useful in evaluating radiotherapy efficacy for HCC.https://www.mdpi.com/2075-4418/11/3/486hepatocellular carcinomaradiotherapycontrast-enhanced ultrasoundsonazoid |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Akihiro Funaoka Kazushi Numata Atsuya Takeda Yusuke Saigusa Yuichirou Tsurugai Hiromi Nihonmatsu Makoto Chuma Hiroyuki Fukuda Masahiro Okada Masayuki Nakano Shin Maeda |
spellingShingle |
Akihiro Funaoka Kazushi Numata Atsuya Takeda Yusuke Saigusa Yuichirou Tsurugai Hiromi Nihonmatsu Makoto Chuma Hiroyuki Fukuda Masahiro Okada Masayuki Nakano Shin Maeda Use of Contrast-Enhanced Ultrasound with Sonazoid for Evaluating the Radiotherapy Efficacy for Hepatocellular Carcinoma Diagnostics hepatocellular carcinoma radiotherapy contrast-enhanced ultrasound sonazoid |
author_facet |
Akihiro Funaoka Kazushi Numata Atsuya Takeda Yusuke Saigusa Yuichirou Tsurugai Hiromi Nihonmatsu Makoto Chuma Hiroyuki Fukuda Masahiro Okada Masayuki Nakano Shin Maeda |
author_sort |
Akihiro Funaoka |
title |
Use of Contrast-Enhanced Ultrasound with Sonazoid for Evaluating the Radiotherapy Efficacy for Hepatocellular Carcinoma |
title_short |
Use of Contrast-Enhanced Ultrasound with Sonazoid for Evaluating the Radiotherapy Efficacy for Hepatocellular Carcinoma |
title_full |
Use of Contrast-Enhanced Ultrasound with Sonazoid for Evaluating the Radiotherapy Efficacy for Hepatocellular Carcinoma |
title_fullStr |
Use of Contrast-Enhanced Ultrasound with Sonazoid for Evaluating the Radiotherapy Efficacy for Hepatocellular Carcinoma |
title_full_unstemmed |
Use of Contrast-Enhanced Ultrasound with Sonazoid for Evaluating the Radiotherapy Efficacy for Hepatocellular Carcinoma |
title_sort |
use of contrast-enhanced ultrasound with sonazoid for evaluating the radiotherapy efficacy for hepatocellular carcinoma |
publisher |
MDPI AG |
series |
Diagnostics |
issn |
2075-4418 |
publishDate |
2021-03-01 |
description |
Radiotherapy is one of the available curative therapies for hepatocellular carcinoma (HCC). We investigate the use of contrast-enhanced ultrasound using Sonazoid (SCEUS) in evaluating the efficacy of radiotherapy for HCC. We enrolled 59 patients with 59 HCCs in this retrospective study. Tumor size and tumor vascularity were evaluated using SCEUS before and 1, 3, 7, 10, and 13 months after radiotherapy. The median follow-up period was 44.5 months (range: 16–82 months). Of the HCCs, 95% (56/59) had no local recurrence, while 5% (3/59) did. At 13 months after radiotherapy, in cases with no local recurrence, SCEUS showed a reduction in tumor vascularity in all cases, while tumor size reduction (>30% reduction, compared with pre-radiotherapy) was observed in 82.1% (46/56). In all three cases of local recurrence, vascularity and tumor size reduction were not observed during the follow-up period and residual HCCs were demonstrated pathologically. Compared with cases with local recurrence, tumor size reduction and reduction in tumor vascularity (<i>p</i> < 0.001) were significantly greater in cases with no local recurrence at 13 months after radiotherapy. SCEUS may be useful in evaluating radiotherapy efficacy for HCC. |
topic |
hepatocellular carcinoma radiotherapy contrast-enhanced ultrasound sonazoid |
url |
https://www.mdpi.com/2075-4418/11/3/486 |
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