The Unusual Suspects in Cytokinesis: Fitting the Pieces Together
Cytokinesis is the step of the cell cycle in which the cell must faithfully separate the chromosomes and cytoplasm, yielding two daughter cells. The assembly and contraction of the contractile network is spatially and temporally coupled with the formation of the mitotic spindle to ensure the success...
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doaj-a1b7aee018ef4f428d4831c9b9a594442020-11-25T03:12:26ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2020-06-01810.3389/fcell.2020.00441545053The Unusual Suspects in Cytokinesis: Fitting the Pieces TogetherLy T. S. Nguyen0Douglas N. Robinson1Douglas N. Robinson2Douglas N. Robinson3Douglas N. Robinson4Douglas N. Robinson5Department of Cell Biology, Johns Hopkins School of Medicine, Baltimore, MD, United StatesDepartment of Cell Biology, Johns Hopkins School of Medicine, Baltimore, MD, United StatesDepartment of Pharmacology and Molecular Sciences, Johns Hopkins School of Medicine, Baltimore, MD, United StatesDepartment of Medicine, Johns Hopkins School of Medicine, Baltimore, MD, United StatesDepartment of Oncology, Johns Hopkins School of Medicine, Baltimore, MD, United StatesChemical and Biomolecular Engineering, Johns Hopkins University Whiting School of Engineering, Baltimore, MD, United StatesCytokinesis is the step of the cell cycle in which the cell must faithfully separate the chromosomes and cytoplasm, yielding two daughter cells. The assembly and contraction of the contractile network is spatially and temporally coupled with the formation of the mitotic spindle to ensure the successful completion of cytokinesis. While decades of studies have elucidated the components of this machinery, the so-called usual suspects, and their functions, many lines of evidence are pointing to other unexpected proteins and sub-cellular systems as also being involved in cytokinesis. These we term the unusual suspects. In this review, we introduce recent discoveries on some of these new unusual suspects and begin to consider how these subcellular systems snap together to help complete the puzzle of cytokinesis.https://www.frontiersin.org/article/10.3389/fcell.2020.00441/fulldiscoidinchloride intracellular channelsimportinsRanhelicasesRNP |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ly T. S. Nguyen Douglas N. Robinson Douglas N. Robinson Douglas N. Robinson Douglas N. Robinson Douglas N. Robinson |
spellingShingle |
Ly T. S. Nguyen Douglas N. Robinson Douglas N. Robinson Douglas N. Robinson Douglas N. Robinson Douglas N. Robinson The Unusual Suspects in Cytokinesis: Fitting the Pieces Together Frontiers in Cell and Developmental Biology discoidin chloride intracellular channels importins Ran helicases RNP |
author_facet |
Ly T. S. Nguyen Douglas N. Robinson Douglas N. Robinson Douglas N. Robinson Douglas N. Robinson Douglas N. Robinson |
author_sort |
Ly T. S. Nguyen |
title |
The Unusual Suspects in Cytokinesis: Fitting the Pieces Together |
title_short |
The Unusual Suspects in Cytokinesis: Fitting the Pieces Together |
title_full |
The Unusual Suspects in Cytokinesis: Fitting the Pieces Together |
title_fullStr |
The Unusual Suspects in Cytokinesis: Fitting the Pieces Together |
title_full_unstemmed |
The Unusual Suspects in Cytokinesis: Fitting the Pieces Together |
title_sort |
unusual suspects in cytokinesis: fitting the pieces together |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Cell and Developmental Biology |
issn |
2296-634X |
publishDate |
2020-06-01 |
description |
Cytokinesis is the step of the cell cycle in which the cell must faithfully separate the chromosomes and cytoplasm, yielding two daughter cells. The assembly and contraction of the contractile network is spatially and temporally coupled with the formation of the mitotic spindle to ensure the successful completion of cytokinesis. While decades of studies have elucidated the components of this machinery, the so-called usual suspects, and their functions, many lines of evidence are pointing to other unexpected proteins and sub-cellular systems as also being involved in cytokinesis. These we term the unusual suspects. In this review, we introduce recent discoveries on some of these new unusual suspects and begin to consider how these subcellular systems snap together to help complete the puzzle of cytokinesis. |
topic |
discoidin chloride intracellular channels importins Ran helicases RNP |
url |
https://www.frontiersin.org/article/10.3389/fcell.2020.00441/full |
work_keys_str_mv |
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