Incidence and outcome of invasive candidiasis in intensive care units (ICUs) in Europe: results of the EUCANDICU project
Abstract Background The objective of this study was to assess the cumulative incidence of invasive candidiasis (IC) in intensive care units (ICUs) in Europe. Methods A multinational, multicenter, retrospective study was conducted in 23 ICUs in 9 European countries, representing the first phase of th...
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2019-06-01
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Online Access: | http://link.springer.com/article/10.1186/s13054-019-2497-3 |
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Matteo Bassetti Daniele R. Giacobbe Antonio Vena Cecilia Trucchi Filippo Ansaldi Massimo Antonelli Vaclava Adamkova Cristiano Alicino Maria-Panagiota Almyroudi Enora Atchade Anna M. Azzini Novella Carannante Alessia Carnelutti Silvia Corcione Andrea Cortegiani George Dimopoulos Simon Dubler José L. García-Garmendia Massimo Girardis Oliver A. Cornely Stefano Ianniruberto Bart Jan Kullberg Katrien Lagrou Clement Le Bihan Roberto Luzzati Manu L. N. G. Malbrain Maria Merelli Ana J. Marques Ignacio Martin-Loeches Alessio Mesini José-Artur Paiva Maddalena Peghin Santi Maurizio Raineri Riina Rautemaa-Richardson Jeroen Schouten Pierluigi Brugnaro Herbert Spapen Polychronis Tasioudis Jean-François Timsit Valentino Tisa Mario Tumbarello Charlotte H. S. B. van den Berg Benoit Veber Mario Venditti Guillaume Voiriot Joost Wauters Philippe Montravers |
spellingShingle |
Matteo Bassetti Daniele R. Giacobbe Antonio Vena Cecilia Trucchi Filippo Ansaldi Massimo Antonelli Vaclava Adamkova Cristiano Alicino Maria-Panagiota Almyroudi Enora Atchade Anna M. Azzini Novella Carannante Alessia Carnelutti Silvia Corcione Andrea Cortegiani George Dimopoulos Simon Dubler José L. García-Garmendia Massimo Girardis Oliver A. Cornely Stefano Ianniruberto Bart Jan Kullberg Katrien Lagrou Clement Le Bihan Roberto Luzzati Manu L. N. G. Malbrain Maria Merelli Ana J. Marques Ignacio Martin-Loeches Alessio Mesini José-Artur Paiva Maddalena Peghin Santi Maurizio Raineri Riina Rautemaa-Richardson Jeroen Schouten Pierluigi Brugnaro Herbert Spapen Polychronis Tasioudis Jean-François Timsit Valentino Tisa Mario Tumbarello Charlotte H. S. B. van den Berg Benoit Veber Mario Venditti Guillaume Voiriot Joost Wauters Philippe Montravers Incidence and outcome of invasive candidiasis in intensive care units (ICUs) in Europe: results of the EUCANDICU project Critical Care ICU Candidemia Candidiasis Candida Abdominal candidiasis Incidence |
author_facet |
Matteo Bassetti Daniele R. Giacobbe Antonio Vena Cecilia Trucchi Filippo Ansaldi Massimo Antonelli Vaclava Adamkova Cristiano Alicino Maria-Panagiota Almyroudi Enora Atchade Anna M. Azzini Novella Carannante Alessia Carnelutti Silvia Corcione Andrea Cortegiani George Dimopoulos Simon Dubler José L. García-Garmendia Massimo Girardis Oliver A. Cornely Stefano Ianniruberto Bart Jan Kullberg Katrien Lagrou Clement Le Bihan Roberto Luzzati Manu L. N. G. Malbrain Maria Merelli Ana J. Marques Ignacio Martin-Loeches Alessio Mesini José-Artur Paiva Maddalena Peghin Santi Maurizio Raineri Riina Rautemaa-Richardson Jeroen Schouten Pierluigi Brugnaro Herbert Spapen Polychronis Tasioudis Jean-François Timsit Valentino Tisa Mario Tumbarello Charlotte H. S. B. van den Berg Benoit Veber Mario Venditti Guillaume Voiriot Joost Wauters Philippe Montravers |
author_sort |
Matteo Bassetti |
title |
Incidence and outcome of invasive candidiasis in intensive care units (ICUs) in Europe: results of the EUCANDICU project |
title_short |
Incidence and outcome of invasive candidiasis in intensive care units (ICUs) in Europe: results of the EUCANDICU project |
title_full |
Incidence and outcome of invasive candidiasis in intensive care units (ICUs) in Europe: results of the EUCANDICU project |
title_fullStr |
Incidence and outcome of invasive candidiasis in intensive care units (ICUs) in Europe: results of the EUCANDICU project |
title_full_unstemmed |
Incidence and outcome of invasive candidiasis in intensive care units (ICUs) in Europe: results of the EUCANDICU project |
title_sort |
incidence and outcome of invasive candidiasis in intensive care units (icus) in europe: results of the eucandicu project |
publisher |
BMC |
series |
Critical Care |
issn |
1364-8535 |
publishDate |
2019-06-01 |
description |
Abstract Background The objective of this study was to assess the cumulative incidence of invasive candidiasis (IC) in intensive care units (ICUs) in Europe. Methods A multinational, multicenter, retrospective study was conducted in 23 ICUs in 9 European countries, representing the first phase of the candidemia/intra-abdominal candidiasis in European ICU project (EUCANDICU). Results During the study period, 570 episodes of ICU-acquired IC were observed, with a cumulative incidence of 7.07 episodes per 1000 ICU admissions, with important between-center variability. Separated, non-mutually exclusive cumulative incidences of candidemia and IAC were 5.52 and 1.84 episodes per 1000 ICU admissions, respectively. Crude 30-day mortality was 42%. Age (odds ratio [OR] 1.04 per year, 95% CI 1.02–1.06, p < 0.001), severe hepatic failure (OR 3.25, 95% 1.31–8.08, p 0.011), SOFA score at the onset of IC (OR 1.11 per point, 95% CI 1.04–1.17, p 0.001), and septic shock (OR 2.12, 95% CI 1.24–3.63, p 0.006) were associated with increased 30-day mortality in a secondary, exploratory analysis. Conclusions The cumulative incidence of IC in 23 European ICUs was 7.07 episodes per 1000 ICU admissions. Future in-depth analyses will allow explaining part of the observed between-center variability, with the ultimate aim of helping to improve local infection control and antifungal stewardship projects and interventions. |
topic |
ICU Candidemia Candidiasis Candida Abdominal candidiasis Incidence |
url |
http://link.springer.com/article/10.1186/s13054-019-2497-3 |
work_keys_str_mv |
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doaj-a1bf8274562848d992e673991012b3c72020-11-25T03:20:47ZengBMCCritical Care1364-85352019-06-012311710.1186/s13054-019-2497-3Incidence and outcome of invasive candidiasis in intensive care units (ICUs) in Europe: results of the EUCANDICU projectMatteo Bassetti0Daniele R. Giacobbe1Antonio Vena2Cecilia Trucchi3Filippo Ansaldi4Massimo Antonelli5Vaclava Adamkova6Cristiano Alicino7Maria-Panagiota Almyroudi8Enora Atchade9Anna M. Azzini10Novella Carannante11Alessia Carnelutti12Silvia Corcione13Andrea Cortegiani14George Dimopoulos15Simon Dubler16José L. García-Garmendia17Massimo Girardis18Oliver A. Cornely19Stefano Ianniruberto20Bart Jan Kullberg21Katrien Lagrou22Clement Le Bihan23Roberto Luzzati24Manu L. N. G. Malbrain25Maria Merelli26Ana J. Marques27Ignacio Martin-Loeches28Alessio Mesini29José-Artur Paiva30Maddalena Peghin31Santi Maurizio Raineri32Riina Rautemaa-Richardson33Jeroen Schouten34Pierluigi Brugnaro35Herbert Spapen36Polychronis Tasioudis37Jean-François Timsit38Valentino Tisa39Mario Tumbarello40Charlotte H. S. B. van den Berg41Benoit Veber42Mario Venditti43Guillaume Voiriot44Joost Wauters45Philippe Montravers46Infectious Diseases Clinic, Department of Medicine University of Udine and Santa Maria Misericordia HospitalDepartment of Health Sciences, University of GenoaInfectious Diseases Clinic, Department of Medicine University of Udine and Santa Maria Misericordia HospitalHealth Planning unit, Azienda Ligure Sanitaria della Regione Liguria (A.Li.Sa.)Department of Health Sciences, University of GenoaDepartment of Intensive Care and Anesthesiology, Università Cattolica del Sacro Cuore, Fondazione Policlinico Universitario Agostino GemelliClinical Microbiology and ATB Centre, Institute of Medical Biochemistry and Laboratory Diagnostics, General University HospitalDepartment of Health Sciences, University of GenoaDepartment of Critical Care, University Hospital Attikon, Medical School, University of AthensDépartement d’Anesthésie-Réanimation, CHU Bichat-Claude Bernard, HUPNVS, APHPDepartment of Diagnostics and Public Health, Infectious Disease Unit, University of VeronaFirst Division, Cotugno Hospital, AO dei ColliInfectious Diseases Clinic, Department of Medicine University of Udine and Santa Maria Misericordia HospitalDepartment of Medical Sciences, Infectious Diseases, University of TurinDepartment of Surgical, Oncological and Oral Science (Di.Chir.On.S.), Section of Anesthesia, Analgesia, Intensive Care and Emergency, Policlinico Paolo Giaccone, University of PalermoDepartment of Critical Care, University Hospital Attikon, Medical School, University of AthensDepartment of Anesthesiology and Intensive Care Medicine, Heidelberg University HospitalServicio de Cuidados Críticos y Urgencias, Hospital San Juan de Dios del AljarafeDepartment of Anesthesia and Intensive Care, University Hospital of ModenaDepartment I of Internal Medicine, University Hospital of Cologne and Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD)Infectious Diseases Unit, Department of Medical and Surgical Science, S. Orsola-Malpighi Hospital, University of BolognaRadboud Center for Infectious Diseases, Radboud University Medical CenterDepartment of Laboratory Medicine and National Reference Centre for Mycosis, University Hospitals of LeuvenBichat-Réanimation médicale et des maladies infectieuses, Medical ICUInfectious Diseases Department, Azienda Sanitaria Universitaria Integrata di TriesteDepartment of Intensive Care Medicine, University Hospital Brussels (UZB), Jette, Belgium and Faculty of Medicine and Pharmacy, Vrije Universiteit Brussel (VUB)Infectious Diseases Clinic, Department of Medicine University of Udine and Santa Maria Misericordia HospitalC.H. Vila Nova de Gaia/EspinhoDepartment of Intensive Care Medicine, Multidisciplinary Intensive Care Research Organization (MICRO), St. James’s HospitalDepartment of Health Sciences, University of GenoaDepartment of Emergency and Intensive Care Medicine, Centro Hospitalar Universitário São João, Faculdade de Medicina da Universidade do Porto e Grupo de Infecção e SépsisInfectious Diseases Clinic, Department of Medicine University of Udine and Santa Maria Misericordia HospitalDepartment of Biopathology and Medical Biotechnologies, Section of Anesthesia, Analgesia, Intensive Care and Emergency, Policlinico P. Giaccone, University of PalermoDepartment of Infectious Diseases, Manchester University NHS Foundation Trust, Wythenshawe Hospital; and Faculty of Biology, Medicine and Health, University of ManchesterRadboud Center for Infectious Diseases, Radboud University Medical CenterInfectious Diseases Department, Ospedale Civile SS. Giovanni e PaoloIntensive Care Department, Vrije Universiteit Brussel (VUB), Universitair Ziekenhuis Brussel (UZ Brussel)G. Gennimatas General Hospital of ThessalonikiUniversité Paris Diderot/Hopital Bichat-Réanimation Medicale et Des Maladies InfectieusesDepartment of Health Sciences, University of GenoaInstitute of Infectious Diseases, Fondazione Policlinico Universitario A. Gemelli IRCCS – Università Cattolica del Sacro CuoreDepartment of Intensive Care, University Medical Center GroningenPole Anesthésie-Réanimation-SAMU, Rouen University HospitalDepartment of Public Health and Infectious Diseases, Sapienza University of RomeSorbonne Université, Assistance Publique-Hôpitaux de Paris, Service de réanimation médico-chirurgicale, Hôpital TenonDepartment of General Internal Medicine, Medical Intensive Care Unit, University Hospitals LeuvenDépartement d’Anesthésie-Réanimation, CHU Bichat-Claude Bernard, HUPNVS, APHPAbstract Background The objective of this study was to assess the cumulative incidence of invasive candidiasis (IC) in intensive care units (ICUs) in Europe. Methods A multinational, multicenter, retrospective study was conducted in 23 ICUs in 9 European countries, representing the first phase of the candidemia/intra-abdominal candidiasis in European ICU project (EUCANDICU). Results During the study period, 570 episodes of ICU-acquired IC were observed, with a cumulative incidence of 7.07 episodes per 1000 ICU admissions, with important between-center variability. Separated, non-mutually exclusive cumulative incidences of candidemia and IAC were 5.52 and 1.84 episodes per 1000 ICU admissions, respectively. Crude 30-day mortality was 42%. Age (odds ratio [OR] 1.04 per year, 95% CI 1.02–1.06, p < 0.001), severe hepatic failure (OR 3.25, 95% 1.31–8.08, p 0.011), SOFA score at the onset of IC (OR 1.11 per point, 95% CI 1.04–1.17, p 0.001), and septic shock (OR 2.12, 95% CI 1.24–3.63, p 0.006) were associated with increased 30-day mortality in a secondary, exploratory analysis. Conclusions The cumulative incidence of IC in 23 European ICUs was 7.07 episodes per 1000 ICU admissions. Future in-depth analyses will allow explaining part of the observed between-center variability, with the ultimate aim of helping to improve local infection control and antifungal stewardship projects and interventions.http://link.springer.com/article/10.1186/s13054-019-2497-3ICUCandidemiaCandidiasisCandidaAbdominal candidiasisIncidence |