HPV infection, anal intra-epithelial neoplasia (AIN) and anal cancer: current issues
<p>Abstract</p> <p>Background</p> <p>Human papillomavirus (HPV) is well known as the major etiological agent for ano-genital cancer. In contrast to cervical cancer, anal cancer is uncommon, but is increasing steadily in the community over the last few decades. However,...
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doaj-a1c6a04abcc54773a28ccccb17c726942020-11-25T00:17:54ZengBMCBMC Cancer1471-24072012-09-0112139810.1186/1471-2407-12-398HPV infection, anal intra-epithelial neoplasia (AIN) and anal cancer: current issuesStanley Margaret AWinder David MSterling Jane CGoon Peter KC<p>Abstract</p> <p>Background</p> <p>Human papillomavirus (HPV) is well known as the major etiological agent for ano-genital cancer. In contrast to cervical cancer, anal cancer is uncommon, but is increasing steadily in the community over the last few decades. However, it has undergone an exponential rise in the men who have sex with men (MSM) and HIV + groups. HIV + MSM in particular, have anal cancer incidences about three times that of the highest worldwide reported cervical cancer incidences.</p> <p>Discussion</p> <p>There has therefore traditionally been a lack of data from studies focused on heterosexual men and non-HIV + women. There is also less evidence reporting on the putative precursor lesion to anal cancer (AIN – anal intraepithelial neoplasia), when compared to cervical cancer and CIN (cervical intraepithelial neoplasia). This review summarises the available biological and epidemiological evidence for HPV in the anal site and the pathogenesis of AIN and anal cancer amongst traditionally non-high risk groups.</p> <p>Summary</p> <p>There is strong evidence to conclude that high-grade AIN is a precursor to anal cancer, and some data on the progression of AIN to invasive cancer.</p> http://www.biomedcentral.com/1471-2407/12/398Anal cancerAnal intraepithelial neoplasiaAINProgressionHuman papillomavirus |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Stanley Margaret A Winder David M Sterling Jane C Goon Peter KC |
spellingShingle |
Stanley Margaret A Winder David M Sterling Jane C Goon Peter KC HPV infection, anal intra-epithelial neoplasia (AIN) and anal cancer: current issues BMC Cancer Anal cancer Anal intraepithelial neoplasia AIN Progression Human papillomavirus |
author_facet |
Stanley Margaret A Winder David M Sterling Jane C Goon Peter KC |
author_sort |
Stanley Margaret A |
title |
HPV infection, anal intra-epithelial neoplasia (AIN) and anal cancer: current issues |
title_short |
HPV infection, anal intra-epithelial neoplasia (AIN) and anal cancer: current issues |
title_full |
HPV infection, anal intra-epithelial neoplasia (AIN) and anal cancer: current issues |
title_fullStr |
HPV infection, anal intra-epithelial neoplasia (AIN) and anal cancer: current issues |
title_full_unstemmed |
HPV infection, anal intra-epithelial neoplasia (AIN) and anal cancer: current issues |
title_sort |
hpv infection, anal intra-epithelial neoplasia (ain) and anal cancer: current issues |
publisher |
BMC |
series |
BMC Cancer |
issn |
1471-2407 |
publishDate |
2012-09-01 |
description |
<p>Abstract</p> <p>Background</p> <p>Human papillomavirus (HPV) is well known as the major etiological agent for ano-genital cancer. In contrast to cervical cancer, anal cancer is uncommon, but is increasing steadily in the community over the last few decades. However, it has undergone an exponential rise in the men who have sex with men (MSM) and HIV + groups. HIV + MSM in particular, have anal cancer incidences about three times that of the highest worldwide reported cervical cancer incidences.</p> <p>Discussion</p> <p>There has therefore traditionally been a lack of data from studies focused on heterosexual men and non-HIV + women. There is also less evidence reporting on the putative precursor lesion to anal cancer (AIN – anal intraepithelial neoplasia), when compared to cervical cancer and CIN (cervical intraepithelial neoplasia). This review summarises the available biological and epidemiological evidence for HPV in the anal site and the pathogenesis of AIN and anal cancer amongst traditionally non-high risk groups.</p> <p>Summary</p> <p>There is strong evidence to conclude that high-grade AIN is a precursor to anal cancer, and some data on the progression of AIN to invasive cancer.</p> |
topic |
Anal cancer Anal intraepithelial neoplasia AIN Progression Human papillomavirus |
url |
http://www.biomedcentral.com/1471-2407/12/398 |
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