Deacetylation-dependent regulation of PARP1 by SIRT2 dictates ubiquitination of PARP1 in oxidative stress-induced vascular injury

Deacetylation-dependent regulation of PARP1 by SIRT2 dictates ubiquitination of PARP1 in oxidative stress-induced vascular injury

Poly(ADP-ribose) polymerase 1 (PARP1) has a major regulatory role in cardiovascular disease. However, inhibiting PARP1 activity does not significantly improve clinical outcomes of cardiovascular disease, which suggests that the regulatory mechanism of PARP1 in cardiovascular disease is unclear. Here...

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Bibliographic Details
Main Authors: Naijin Zhang, Ying Zhang, Boquan Wu, Shaojun Wu, Shilong You, Saien Lu, Jingwei Liu, Xinyue Huang, Jiaqi Xu, Liu Cao, Yingxian Sun
Format: Article
Language:English
Published: Elsevier 2021-11-01
Series:Redox Biology
Subjects:
SIRT2
WWP2
PARP1
Acetylation
Ubiquitination
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231721003001

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