Several Follicular Regulatory T Cell Subsets With Distinct Phenotype and Function Emerge During Germinal Center Reactions

Several Follicular Regulatory T Cell Subsets With Distinct Phenotype and Function Emerge During Germinal Center Reactions

An efficient B cell immunity requires a dynamic equilibrium between positive and negative signals. In germinal centers (GCs), T follicular helper cells are supposed to be the positive regulator while T follicular regulatory (Tfr) cells were assigned to be the negative regulators. Indeed, Tfr cells a...

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Main Authors: Nicolas Fazilleau, Meryem Aloulou
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-08-01
Series:Frontiers in Immunology
Subjects:
T follicular regulatory cells
germinal centers
heterogeneity
subsets
T follicular helper cells
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.01792/full
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spelling doaj-a1c9e8c9e5f74715bf537ca6770575642020-11-24T23:11:08ZengFrontiers Media S.A.Frontiers in Immunology1664-32242018-08-01910.3389/fimmu.2018.01792405154Several Follicular Regulatory T Cell Subsets With Distinct Phenotype and Function Emerge During Germinal Center ReactionsNicolas Fazilleau0Nicolas Fazilleau1Nicolas Fazilleau2Nicolas Fazilleau3Meryem Aloulou4Meryem Aloulou5Meryem Aloulou6Meryem Aloulou7Centre de Physiopathologie de Toulouse Purpan, Toulouse, FranceINSERM U1043, Toulouse, FranceCNRS UMR5282, Toulouse, FranceUniversité Toulouse III Paul-Sabatier, Toulouse, FranceCentre de Physiopathologie de Toulouse Purpan, Toulouse, FranceINSERM U1043, Toulouse, FranceCNRS UMR5282, Toulouse, FranceUniversité Toulouse III Paul-Sabatier, Toulouse, FranceAn efficient B cell immunity requires a dynamic equilibrium between positive and negative signals. In germinal centers (GCs), T follicular helper cells are supposed to be the positive regulator while T follicular regulatory (Tfr) cells were assigned to be the negative regulators. Indeed, Tfr cells are considered as a homogenous cell population dedicated to dampen the GC extent. Moreover, Tfr cells prevent autoimmunity since their dysregulation leads to production of self-reactive antibodies (Ab). However, a growing corpus of evidence has revealed additional and unexpected functions for Tfr cells in the regulation of B cell responses. This review provides an overview of the Tfr cell contribution and presents Tfr cell proprieties in the context of vaccination.https://www.frontiersin.org/article/10.3389/fimmu.2018.01792/fullT follicular regulatory cellsgerminal centersheterogeneitysubsetsT follicular helper cells
collection DOAJ
language English
format Article
sources DOAJ
author Nicolas Fazilleau
Nicolas Fazilleau
Nicolas Fazilleau
Nicolas Fazilleau
Meryem Aloulou
Meryem Aloulou
Meryem Aloulou
Meryem Aloulou
spellingShingle Nicolas Fazilleau
Nicolas Fazilleau
Nicolas Fazilleau
Nicolas Fazilleau
Meryem Aloulou
Meryem Aloulou
Meryem Aloulou
Meryem Aloulou
Several Follicular Regulatory T Cell Subsets With Distinct Phenotype and Function Emerge During Germinal Center Reactions
Frontiers in Immunology
T follicular regulatory cells
germinal centers
heterogeneity
subsets
T follicular helper cells
author_facet Nicolas Fazilleau
Nicolas Fazilleau
Nicolas Fazilleau
Nicolas Fazilleau
Meryem Aloulou
Meryem Aloulou
Meryem Aloulou
Meryem Aloulou
author_sort Nicolas Fazilleau
title Several Follicular Regulatory T Cell Subsets With Distinct Phenotype and Function Emerge During Germinal Center Reactions
title_short Several Follicular Regulatory T Cell Subsets With Distinct Phenotype and Function Emerge During Germinal Center Reactions
title_full Several Follicular Regulatory T Cell Subsets With Distinct Phenotype and Function Emerge During Germinal Center Reactions
title_fullStr Several Follicular Regulatory T Cell Subsets With Distinct Phenotype and Function Emerge During Germinal Center Reactions
title_full_unstemmed Several Follicular Regulatory T Cell Subsets With Distinct Phenotype and Function Emerge During Germinal Center Reactions
title_sort several follicular regulatory t cell subsets with distinct phenotype and function emerge during germinal center reactions
publisher Frontiers Media S.A.
series Frontiers in Immunology
issn 1664-3224
publishDate 2018-08-01
description An efficient B cell immunity requires a dynamic equilibrium between positive and negative signals. In germinal centers (GCs), T follicular helper cells are supposed to be the positive regulator while T follicular regulatory (Tfr) cells were assigned to be the negative regulators. Indeed, Tfr cells are considered as a homogenous cell population dedicated to dampen the GC extent. Moreover, Tfr cells prevent autoimmunity since their dysregulation leads to production of self-reactive antibodies (Ab). However, a growing corpus of evidence has revealed additional and unexpected functions for Tfr cells in the regulation of B cell responses. This review provides an overview of the Tfr cell contribution and presents Tfr cell proprieties in the context of vaccination.
topic T follicular regulatory cells
germinal centers
heterogeneity
subsets
T follicular helper cells
url https://www.frontiersin.org/article/10.3389/fimmu.2018.01792/full
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