Cutaneous adverse drug reactions: clinical pattern and causative agents--a 6 year series from Chandigarh, India.
AIM: To study the different clinical spectrum of cutaneous adverse drug reactions (ADR) and to determine the causative drugs. MATERIALS & METHODS: A prospective, hospital based study was carried out over a period of 6 years recording various cutaneous ADR. RESULTS: A total of 500 patients...
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2001-04-01
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doaj-a1d06892804e4ee5b00c8bb4b881844a2020-11-25T00:44:03ZengWolters Kluwer Medknow PublicationsJournal of Postgraduate Medicine0022-38590972-28232001-04-01472959Cutaneous adverse drug reactions: clinical pattern and causative agents--a 6 year series from Chandigarh, India.Sharma VSethuraman GKumar BAIM: To study the different clinical spectrum of cutaneous adverse drug reactions (ADR) and to determine the causative drugs. MATERIALS & METHODS: A prospective, hospital based study was carried out over a period of 6 years recording various cutaneous ADR. RESULTS: A total of 500 patients with cutaneous ADR were enrolled in the study. The most common types of cutaneous ADR patterns were maculopapular rash (34.6%), fixed drug eruption (FDE) (30%) and urticaria (14%). The drugs most often incriminated for the various cutaneous ADR were antimicrobials (42.6%), anticonvulsants (22.2%) and NSAIDs (18%). Anticonvulsants were implicated in 41.6% of maculopapular rashes. Sulfonamides accounted for 43.3% and NSAIDs for 30.7% of FDE. Urticaria was caused mainly by NSAIDs(24.3%) and penicillins(20%). Anticonvulsants were responsible for 43.8% of life-threatening toxic epidermal necrolysis and Stevens Johnson syndrome. CONCLUSIONS: The clinical pattern and drugs causing cutaneous ADR are similar to those observed in other countries except for minor variations. Cutaneous ADR patterns and the drugs causing various reactions are changing every year, which may be due to the emergence of newer molecules and changing trends in the use of drugs.http://www.jpgmonline.com/article.asp?issn=0022-3859;year=2001;volume=47;issue=2;spage=95;epage=9;aulast=SharmaAdolescentAdultAdverse Drug Reaction Reporting SystemsAgedAnti-Inflammatory AgentsNon-Steroidaladverse effectsAntibioticsadverse effectsAnticonvulsantsadverse effectsChildChildPreschoolDrug EruptionsepidemiologyetiologyFemaleHumanIndiaepidemiologyInfantMaleMiddle AgeProspective Studies |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Sharma V Sethuraman G Kumar B |
spellingShingle |
Sharma V Sethuraman G Kumar B Cutaneous adverse drug reactions: clinical pattern and causative agents--a 6 year series from Chandigarh, India. Journal of Postgraduate Medicine Adolescent Adult Adverse Drug Reaction Reporting Systems Aged Anti-Inflammatory Agents Non-Steroidal adverse effects Antibiotics adverse effects Anticonvulsants adverse effects Child Child Preschool Drug Eruptions epidemiology etiology Female Human India epidemiology Infant Male Middle Age Prospective Studies |
author_facet |
Sharma V Sethuraman G Kumar B |
author_sort |
Sharma V |
title |
Cutaneous adverse drug reactions: clinical pattern and causative agents--a 6 year series from Chandigarh, India. |
title_short |
Cutaneous adverse drug reactions: clinical pattern and causative agents--a 6 year series from Chandigarh, India. |
title_full |
Cutaneous adverse drug reactions: clinical pattern and causative agents--a 6 year series from Chandigarh, India. |
title_fullStr |
Cutaneous adverse drug reactions: clinical pattern and causative agents--a 6 year series from Chandigarh, India. |
title_full_unstemmed |
Cutaneous adverse drug reactions: clinical pattern and causative agents--a 6 year series from Chandigarh, India. |
title_sort |
cutaneous adverse drug reactions: clinical pattern and causative agents--a 6 year series from chandigarh, india. |
publisher |
Wolters Kluwer Medknow Publications |
series |
Journal of Postgraduate Medicine |
issn |
0022-3859 0972-2823 |
publishDate |
2001-04-01 |
description |
AIM: To study the different clinical spectrum of cutaneous adverse drug reactions (ADR) and to determine the causative drugs. MATERIALS & METHODS: A prospective, hospital based study was carried out over a period of 6 years recording various cutaneous ADR. RESULTS: A total of 500 patients with cutaneous ADR were enrolled in the study. The most common types of cutaneous ADR patterns were maculopapular rash (34.6%), fixed drug eruption (FDE) (30%) and urticaria (14%). The drugs most often incriminated for the various cutaneous ADR were antimicrobials (42.6%), anticonvulsants (22.2%) and NSAIDs (18%). Anticonvulsants were implicated in 41.6% of maculopapular rashes. Sulfonamides accounted for 43.3% and NSAIDs for 30.7% of FDE. Urticaria was caused mainly by NSAIDs(24.3%) and penicillins(20%). Anticonvulsants were responsible for 43.8% of life-threatening toxic epidermal necrolysis and Stevens Johnson syndrome. CONCLUSIONS: The clinical pattern and drugs causing cutaneous ADR are similar to those observed in other countries except for minor variations. Cutaneous ADR patterns and the drugs causing various reactions are changing every year, which may be due to the emergence of newer molecules and changing trends in the use of drugs. |
topic |
Adolescent Adult Adverse Drug Reaction Reporting Systems Aged Anti-Inflammatory Agents Non-Steroidal adverse effects Antibiotics adverse effects Anticonvulsants adverse effects Child Child Preschool Drug Eruptions epidemiology etiology Female Human India epidemiology Infant Male Middle Age Prospective Studies |
url |
http://www.jpgmonline.com/article.asp?issn=0022-3859;year=2001;volume=47;issue=2;spage=95;epage=9;aulast=Sharma |
work_keys_str_mv |
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