Caveolin‐1‐driven membrane remodelling regulates hnRNPK‐mediated exosomal microRNA sorting in cancer
Abstract Background Caveolae proteins play diverse roles in cancer development and progression. In prostate cancer, non‐caveolar caveolin‐1 (CAV1) promotes metastasis, while CAVIN1 attenuates CAV1‐induced metastasis. Here, we unveil a novel mechanism linking CAV1 to selective loading of exosomes wit...
Main Authors: | Harley Robinson, Jayde E. Ruelcke, Amanda Lewis, Charles S. Bond, Archa H. Fox, Vandhana Bharti, Shivangi Wani, Nicole Cloonan, Andrew Lai, David Margolin, Li Li, Carlos Salomon, Renée S. Richards, Aine Farrell, Robert A. Gardiner, Robert G. Parton, Alexandre S. Cristino, Michelle M. Hill |
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Format: | Article |
Language: | English |
Published: |
Wiley
2021-04-01
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Series: | Clinical and Translational Medicine |
Subjects: | |
Online Access: | https://doi.org/10.1002/ctm2.381 |
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